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Q9ZD29

- CLPP_RICPR

UniProt

Q9ZD29 - CLPP_RICPR

Protein

ATP-dependent Clp protease proteolytic subunit

Gene

clpP

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.UniRule annotation

    Catalytic activityi

    Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei98 – 981NucleophileUniRule annotation
    Active sitei123 – 1231UniRule annotation

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS14.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent Clp protease proteolytic subunitUniRule annotation (EC:3.4.21.92UniRule annotation)
    Alternative name(s):
    Endopeptidase ClpUniRule annotation
    Gene namesi
    Name:clpPUniRule annotation
    Ordered Locus Names:RP520
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 201201ATP-dependent Clp protease proteolytic subunitPRO_0000179640Add
    BLAST

    Interactioni

    Subunit structurei

    Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

    Protein-protein interaction databases

    STRINGi272947.RP520.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZD29.
    SMRiQ9ZD29. Positions 4-194.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S14 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0740.
    HOGENOMiHOG000285833.
    KOiK01358.
    OMAiKGERSFD.
    OrthoDBiEOG6Z3KQ0.

    Family and domain databases

    Gene3Di3.90.226.10. 1 hit.
    HAMAPiMF_00444. ClpP.
    InterProiIPR001907. ClpP.
    IPR029045. ClpP/crotonase-like_dom.
    IPR023562. ClpP/TepA.
    IPR018215. ClpP_AS.
    [Graphical view]
    PANTHERiPTHR10381. PTHR10381. 1 hit.
    PfamiPF00574. CLP_protease. 1 hit.
    [Graphical view]
    PRINTSiPR00127. CLPPROTEASEP.
    SUPFAMiSSF52096. SSF52096. 1 hit.
    TIGRFAMsiTIGR00493. clpP. 1 hit.
    PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
    PS00381. CLP_PROTEASE_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZD29-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYVPVVIEQ TSRGERAYDI YSRLLKERII FVCSTVEDHM ANLIVAQLLF    50
    LEAENPKKDI YMYINSPGGV VTAGLAIYDT MQFIKPKVAT LCIGQACSMG 100
    SLLLCGGEHG MRYSLPHSRI MIHQPSGGYK GQATDIEIHA RETLKIKRLL 150
    NELYSKHTKQ ELKYIEKSME RDNFMSSEEA KKFGLVDNII SSRDTIAFLA 200
    Q 201
    Length:201
    Mass (Da):22,715
    Last modified:May 1, 1999 - v1
    Checksum:i31E5B3FCC60E19EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235272 Genomic DNA. Translation: CAA14970.1.
    PIRiH71655.
    RefSeqiNP_220894.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14970; CAA14970; CAA14970.
    GeneIDi883186.
    KEGGirpr:RP520.
    PATRICi17901826. VBIRicPro72556_0529.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235272 Genomic DNA. Translation: CAA14970.1 .
    PIRi H71655.
    RefSeqi NP_220894.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZD29.
    SMRi Q9ZD29. Positions 4-194.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP520.

    Protein family/group databases

    MEROPSi S14.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14970 ; CAA14970 ; CAA14970 .
    GeneIDi 883186.
    KEGGi rpr:RP520.
    PATRICi 17901826. VBIRicPro72556_0529.

    Phylogenomic databases

    eggNOGi COG0740.
    HOGENOMi HOG000285833.
    KOi K01358.
    OMAi KGERSFD.
    OrthoDBi EOG6Z3KQ0.

    Family and domain databases

    Gene3Di 3.90.226.10. 1 hit.
    HAMAPi MF_00444. ClpP.
    InterProi IPR001907. ClpP.
    IPR029045. ClpP/crotonase-like_dom.
    IPR023562. ClpP/TepA.
    IPR018215. ClpP_AS.
    [Graphical view ]
    PANTHERi PTHR10381. PTHR10381. 1 hit.
    Pfami PF00574. CLP_protease. 1 hit.
    [Graphical view ]
    PRINTSi PR00127. CLPPROTEASEP.
    SUPFAMi SSF52096. SSF52096. 1 hit.
    TIGRFAMsi TIGR00493. clpP. 1 hit.
    PROSITEi PS00382. CLP_PROTEASE_HIS. 1 hit.
    PS00381. CLP_PROTEASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiCLPP_RICPR
    AccessioniPrimary (citable) accession number: Q9ZD29
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3