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Q9ZCZ1

- FAD3_RICPR

UniProt

Q9ZCZ1 - FAD3_RICPR

Protein

Putative fatty acid oxidation complex trifunctional enzyme

Gene

RP560

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.
    (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.
    (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA.

    GO - Molecular functioni

    1. 3-hydroxyacyl-CoA dehydrogenase activity Source: UniProtKB-EC
    2. coenzyme binding Source: InterPro
    3. dodecenoyl-CoA delta-isomerase activity Source: UniProtKB-EC
    4. enoyl-CoA hydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Lyase, Oxidoreductase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative fatty acid oxidation complex trifunctional enzyme
    Including the following 2 domains:
    3-hydroxyacyl-CoA dehydrogenase (EC:1.1.1.35)
    Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase (EC:4.2.1.17, EC:5.3.3.8)
    Gene namesi
    Ordered Locus Names:RP560
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 720720Putative fatty acid oxidation complex trifunctional enzymePRO_0000285698Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272947.RP560.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZCZ1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 3843843-hydroxyacyl-CoA dehydrogenaseAdd
    BLAST
    Regioni453 – 720268Enoyl-CoA hydratase/isomeraseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.Curated
    In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.Curated

    Phylogenomic databases

    eggNOGiCOG1250.
    HOGENOMiHOG000264370.
    KOiK01782.
    OMAiKGPLEFA.
    OrthoDBiEOG6B8XF5.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    3.90.226.10. 1 hit.
    InterProiIPR006176. 3-OHacyl-CoA_DH_NAD-bd.
    IPR006108. 3HC_DH_C.
    IPR008927. 6-PGluconate_DH_C-like.
    IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00725. 3HCDH. 1 hit.
    PF02737. 3HCDH_N. 1 hit.
    PF00378. ECH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 2 hits.
    SSF52096. SSF52096. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZCZ1-1 [UniParc]FASTAAdd to Basket

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    MQNEIKKVCV IGAGVMGSGI AALIANSSHQ VVLLDILDKD SNDPNKIVKN    50
    SVKNLHKQKL SPLSFPDKVN FITIGNLEHD LDLIKECNLV IEVIVEKLEI 100
    KHQLYNKIIP YLKEDAIIAS NTSTLPLKKL KVNLPNNIKS RFVITHFFNP 150
    PRYMELVELI IDHTIKDEVI EKVSVFLTKM LGKTIIKCND TPGFIANRVG 200
    CFLLELVVHK AIAQNLNFVT IDQIFSRCLG LPNTGIFGLY DLIGHDVMKL 250
    ISSSLISALP KSDDYHRIYT NTKVFDKMIE HNLIGRKGEG GFYRLSVSNG 300
    KKIKEVINIS DLSYHPVQKV DISFNSLNEL LSSNSIYGKF FSEIITEFYI 350
    YLTSLVPSVT NNIYDIDTTM KLGYSWHYGP FELLTIAVKN GWNLIIKNAD 400
    LMNIPLPKYL ASKEYQKIDK QKFNSKKDFL QESKIVLSND SANLIHYCEN 450
    LVFVITTKMN SLNHNVFYLL QEAVSKAENY GKNLYIYPQG NNFSAGADLK 500
    LILSYIQDGN FHNLENLLKL GQQTMRYLKY SSVHIISCAR GVALGGGCEL 550
    LLNSSYIVAN QELNAGLIEL GVGLIPGWTG VTEMFARSNG NKTKLIRNIK 600
    NIIEQNKTSS ADYFKADYGI KNMQVNMNKH YILDDALKLR ISKKIVSIPN 650
    KITLPKINIV SEIDTSKYNE LQNKVLNKFQ NIIDKHNEIS EAELLTYERE 700
    MFLELAKTPQ TIEKLQAIVG 720
    Length:720
    Mass (Da):81,403
    Last modified:May 1, 1999 - v1
    Checksum:iBAEC37A40044234E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235272 Genomic DNA. Translation: CAA15008.1.
    PIRiF71660.
    RefSeqiNP_220931.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA15008; CAA15008; CAA15008.
    GeneIDi883251.
    KEGGirpr:RP560.
    PATRICi17901919. VBIRicPro72556_0573.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235272 Genomic DNA. Translation: CAA15008.1 .
    PIRi F71660.
    RefSeqi NP_220931.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZCZ1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP560.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA15008 ; CAA15008 ; CAA15008 .
    GeneIDi 883251.
    KEGGi rpr:RP560.
    PATRICi 17901919. VBIRicPro72556_0573.

    Phylogenomic databases

    eggNOGi COG1250.
    HOGENOMi HOG000264370.
    KOi K01782.
    OMAi KGPLEFA.
    OrthoDBi EOG6B8XF5.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    3.90.226.10. 1 hit.
    InterProi IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
    IPR006108. 3HC_DH_C.
    IPR008927. 6-PGluconate_DH_C-like.
    IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00725. 3HCDH. 1 hit.
    PF02737. 3HCDH_N. 1 hit.
    PF00378. ECH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 2 hits.
    SSF52096. SSF52096. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiFAD3_RICPR
    AccessioniPrimary (citable) accession number: Q9ZCZ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3