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Protein

Putative fatty acid oxidation complex trifunctional enzyme

Gene

RP560

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.
A (3Z)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA.
A (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Lyase, Multifunctional enzyme, Oxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandNAD

Enzyme and pathway databases

BioCyciRPRO272947:G1GT0-559-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative fatty acid oxidation complex trifunctional enzyme
Including the following 2 domains:
3-hydroxyacyl-CoA dehydrogenase (EC:1.1.1.35)
Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase (EC:4.2.1.17, EC:5.3.3.8)
Gene namesi
Ordered Locus Names:RP560
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000002480 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002856981 – 720Putative fatty acid oxidation complex trifunctional enzymeAdd BLAST720

Interactioni

Protein-protein interaction databases

STRINGi272947.RP560

Structurei

3D structure databases

ProteinModelPortaliQ9ZCZ1
SMRiQ9ZCZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 3843-hydroxyacyl-CoA dehydrogenaseAdd BLAST384
Regioni453 – 720Enoyl-CoA hydratase/isomeraseAdd BLAST268

Sequence similaritiesi

In the N-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.Curated
In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.Curated

Phylogenomic databases

eggNOGiENOG4105DYT Bacteria
COG1024 LUCA
COG1250 LUCA
HOGENOMiHOG000264370
KOiK01782
OMAiGQGFYKK

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR006176 3-OHacyl-CoA_DH_NAD-bd
IPR006108 3HC_DH_C
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR029045 ClpP/crotonase-like_dom_sf
IPR032259 HIBYL-CoA-H
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00725 3HCDH, 1 hit
PF02737 3HCDH_N, 1 hit
PF16113 ECH_2, 1 hit
SUPFAMiSSF48179 SSF48179, 2 hits
SSF51735 SSF51735, 1 hit
SSF52096 SSF52096, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZCZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNEIKKVCV IGAGVMGSGI AALIANSSHQ VVLLDILDKD SNDPNKIVKN
60 70 80 90 100
SVKNLHKQKL SPLSFPDKVN FITIGNLEHD LDLIKECNLV IEVIVEKLEI
110 120 130 140 150
KHQLYNKIIP YLKEDAIIAS NTSTLPLKKL KVNLPNNIKS RFVITHFFNP
160 170 180 190 200
PRYMELVELI IDHTIKDEVI EKVSVFLTKM LGKTIIKCND TPGFIANRVG
210 220 230 240 250
CFLLELVVHK AIAQNLNFVT IDQIFSRCLG LPNTGIFGLY DLIGHDVMKL
260 270 280 290 300
ISSSLISALP KSDDYHRIYT NTKVFDKMIE HNLIGRKGEG GFYRLSVSNG
310 320 330 340 350
KKIKEVINIS DLSYHPVQKV DISFNSLNEL LSSNSIYGKF FSEIITEFYI
360 370 380 390 400
YLTSLVPSVT NNIYDIDTTM KLGYSWHYGP FELLTIAVKN GWNLIIKNAD
410 420 430 440 450
LMNIPLPKYL ASKEYQKIDK QKFNSKKDFL QESKIVLSND SANLIHYCEN
460 470 480 490 500
LVFVITTKMN SLNHNVFYLL QEAVSKAENY GKNLYIYPQG NNFSAGADLK
510 520 530 540 550
LILSYIQDGN FHNLENLLKL GQQTMRYLKY SSVHIISCAR GVALGGGCEL
560 570 580 590 600
LLNSSYIVAN QELNAGLIEL GVGLIPGWTG VTEMFARSNG NKTKLIRNIK
610 620 630 640 650
NIIEQNKTSS ADYFKADYGI KNMQVNMNKH YILDDALKLR ISKKIVSIPN
660 670 680 690 700
KITLPKINIV SEIDTSKYNE LQNKVLNKFQ NIIDKHNEIS EAELLTYERE
710 720
MFLELAKTPQ TIEKLQAIVG
Length:720
Mass (Da):81,403
Last modified:May 1, 1999 - v1
Checksum:iBAEC37A40044234E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235272 Genomic DNA Translation: CAA15008.1
PIRiF71660
RefSeqiNP_220931.1, NC_000963.1
WP_004599039.1, NC_000963.1

Genome annotation databases

EnsemblBacteriaiCAA15008; CAA15008; CAA15008
GeneIDi883251
KEGGirpr:RP560
PATRICifig|272947.5.peg.573

Similar proteinsi

Entry informationi

Entry nameiFAD3_RICPR
AccessioniPrimary (citable) accession number: Q9ZCZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health