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Q9ZCZ1

- FAD3_RICPR

UniProt

Q9ZCZ1 - FAD3_RICPR

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Protein
Putative fatty acid oxidation complex trifunctional enzyme
Gene
RP560
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.
(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA.

GO - Molecular functioni

  1. 3-hydroxyacyl-CoA dehydrogenase activity Source: UniProtKB-EC
  2. coenzyme binding Source: InterPro
  3. dodecenoyl-CoA delta-isomerase activity Source: UniProtKB-EC
  4. enoyl-CoA hydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Lyase, Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative fatty acid oxidation complex trifunctional enzyme
Including the following 2 domains:
3-hydroxyacyl-CoA dehydrogenase (EC:1.1.1.35)
Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase (EC:4.2.1.17, EC:5.3.3.8)
Gene namesi
Ordered Locus Names:RP560
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 720720Putative fatty acid oxidation complex trifunctional enzyme
PRO_0000285698Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272947.RP560.

Structurei

3D structure databases

ProteinModelPortaliQ9ZCZ1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 3843843-hydroxyacyl-CoA dehydrogenase
Add
BLAST
Regioni453 – 720268Enoyl-CoA hydratase/isomerase
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

Phylogenomic databases

eggNOGiCOG1250.
HOGENOMiHOG000264370.
KOiK01782.
OMAiKGPLEFA.
OrthoDBiEOG6B8XF5.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
3.90.226.10. 1 hit.
InterProiIPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZCZ1-1 [UniParc]FASTAAdd to Basket

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MQNEIKKVCV IGAGVMGSGI AALIANSSHQ VVLLDILDKD SNDPNKIVKN    50
SVKNLHKQKL SPLSFPDKVN FITIGNLEHD LDLIKECNLV IEVIVEKLEI 100
KHQLYNKIIP YLKEDAIIAS NTSTLPLKKL KVNLPNNIKS RFVITHFFNP 150
PRYMELVELI IDHTIKDEVI EKVSVFLTKM LGKTIIKCND TPGFIANRVG 200
CFLLELVVHK AIAQNLNFVT IDQIFSRCLG LPNTGIFGLY DLIGHDVMKL 250
ISSSLISALP KSDDYHRIYT NTKVFDKMIE HNLIGRKGEG GFYRLSVSNG 300
KKIKEVINIS DLSYHPVQKV DISFNSLNEL LSSNSIYGKF FSEIITEFYI 350
YLTSLVPSVT NNIYDIDTTM KLGYSWHYGP FELLTIAVKN GWNLIIKNAD 400
LMNIPLPKYL ASKEYQKIDK QKFNSKKDFL QESKIVLSND SANLIHYCEN 450
LVFVITTKMN SLNHNVFYLL QEAVSKAENY GKNLYIYPQG NNFSAGADLK 500
LILSYIQDGN FHNLENLLKL GQQTMRYLKY SSVHIISCAR GVALGGGCEL 550
LLNSSYIVAN QELNAGLIEL GVGLIPGWTG VTEMFARSNG NKTKLIRNIK 600
NIIEQNKTSS ADYFKADYGI KNMQVNMNKH YILDDALKLR ISKKIVSIPN 650
KITLPKINIV SEIDTSKYNE LQNKVLNKFQ NIIDKHNEIS EAELLTYERE 700
MFLELAKTPQ TIEKLQAIVG 720
Length:720
Mass (Da):81,403
Last modified:May 1, 1999 - v1
Checksum:iBAEC37A40044234E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235272 Genomic DNA. Translation: CAA15008.1.
PIRiF71660.
RefSeqiNP_220931.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA15008; CAA15008; CAA15008.
GeneIDi883251.
KEGGirpr:RP560.
PATRICi17901919. VBIRicPro72556_0573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235272 Genomic DNA. Translation: CAA15008.1 .
PIRi F71660.
RefSeqi NP_220931.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZCZ1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP560.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA15008 ; CAA15008 ; CAA15008 .
GeneIDi 883251.
KEGGi rpr:RP560.
PATRICi 17901919. VBIRicPro72556_0573.

Phylogenomic databases

eggNOGi COG1250.
HOGENOMi HOG000264370.
KOi K01782.
OMAi KGPLEFA.
OrthoDBi EOG6B8XF5.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
3.90.226.10. 1 hit.
InterProi IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiFAD3_RICPR
AccessioniPrimary (citable) accession number: Q9ZCZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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