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Protein

Putative fatty acid oxidation complex trifunctional enzyme

Gene

RP560

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.
(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Lyase, Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative fatty acid oxidation complex trifunctional enzyme
Including the following 2 domains:
3-hydroxyacyl-CoA dehydrogenase (EC:1.1.1.35)
Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase (EC:4.2.1.17, EC:5.3.3.8)
Gene namesi
Ordered Locus Names:RP560
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 720720Putative fatty acid oxidation complex trifunctional enzymePRO_0000285698Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272947.RP560.

Structurei

3D structure databases

ProteinModelPortaliQ9ZCZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 3843843-hydroxyacyl-CoA dehydrogenaseAdd
BLAST
Regioni453 – 720268Enoyl-CoA hydratase/isomeraseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.Curated
In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.Curated

Phylogenomic databases

eggNOGiCOG1250.
HOGENOMiHOG000264370.
KOiK01782.
OMAiHVLEYMH.
OrthoDBiEOG6B8XF5.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
3.90.226.10. 1 hit.
InterProiIPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZCZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNEIKKVCV IGAGVMGSGI AALIANSSHQ VVLLDILDKD SNDPNKIVKN
60 70 80 90 100
SVKNLHKQKL SPLSFPDKVN FITIGNLEHD LDLIKECNLV IEVIVEKLEI
110 120 130 140 150
KHQLYNKIIP YLKEDAIIAS NTSTLPLKKL KVNLPNNIKS RFVITHFFNP
160 170 180 190 200
PRYMELVELI IDHTIKDEVI EKVSVFLTKM LGKTIIKCND TPGFIANRVG
210 220 230 240 250
CFLLELVVHK AIAQNLNFVT IDQIFSRCLG LPNTGIFGLY DLIGHDVMKL
260 270 280 290 300
ISSSLISALP KSDDYHRIYT NTKVFDKMIE HNLIGRKGEG GFYRLSVSNG
310 320 330 340 350
KKIKEVINIS DLSYHPVQKV DISFNSLNEL LSSNSIYGKF FSEIITEFYI
360 370 380 390 400
YLTSLVPSVT NNIYDIDTTM KLGYSWHYGP FELLTIAVKN GWNLIIKNAD
410 420 430 440 450
LMNIPLPKYL ASKEYQKIDK QKFNSKKDFL QESKIVLSND SANLIHYCEN
460 470 480 490 500
LVFVITTKMN SLNHNVFYLL QEAVSKAENY GKNLYIYPQG NNFSAGADLK
510 520 530 540 550
LILSYIQDGN FHNLENLLKL GQQTMRYLKY SSVHIISCAR GVALGGGCEL
560 570 580 590 600
LLNSSYIVAN QELNAGLIEL GVGLIPGWTG VTEMFARSNG NKTKLIRNIK
610 620 630 640 650
NIIEQNKTSS ADYFKADYGI KNMQVNMNKH YILDDALKLR ISKKIVSIPN
660 670 680 690 700
KITLPKINIV SEIDTSKYNE LQNKVLNKFQ NIIDKHNEIS EAELLTYERE
710 720
MFLELAKTPQ TIEKLQAIVG
Length:720
Mass (Da):81,403
Last modified:May 1, 1999 - v1
Checksum:iBAEC37A40044234E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235272 Genomic DNA. Translation: CAA15008.1.
PIRiF71660.
RefSeqiNP_220931.1. NC_000963.1.
WP_004599039.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA15008; CAA15008; CAA15008.
GeneIDi883251.
KEGGirpr:RP560.
PATRICi17901919. VBIRicPro72556_0573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235272 Genomic DNA. Translation: CAA15008.1.
PIRiF71660.
RefSeqiNP_220931.1. NC_000963.1.
WP_004599039.1. NC_000963.1.

3D structure databases

ProteinModelPortaliQ9ZCZ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272947.RP560.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA15008; CAA15008; CAA15008.
GeneIDi883251.
KEGGirpr:RP560.
PATRICi17901919. VBIRicPro72556_0573.

Phylogenomic databases

eggNOGiCOG1250.
HOGENOMiHOG000264370.
KOiK01782.
OMAiHVLEYMH.
OrthoDBiEOG6B8XF5.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
3.90.226.10. 1 hit.
InterProiIPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiFAD3_RICPR
AccessioniPrimary (citable) accession number: Q9ZCZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 1999
Last modified: July 22, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.