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Q9ZCZ1 (FAD3_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative fatty acid oxidation complex trifunctional enzyme

Including the following 2 domains:

  1. 3-hydroxyacyl-CoA dehydrogenase
    EC=1.1.1.35
  2. Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase
    EC=4.2.1.17
    EC=5.3.3.8
Gene names
Ordered Locus Names:RP560
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length720 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.

(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.

(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA.

Sequence similarities

In the N-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 720720Putative fatty acid oxidation complex trifunctional enzyme
PRO_0000285698

Regions

Region1 – 3843843-hydroxyacyl-CoA dehydrogenase
Region453 – 720268Enoyl-CoA hydratase/isomerase

Sequences

Sequence LengthMass (Da)Tools
Q9ZCZ1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: BAEC37A40044234E

FASTA72081,403
        10         20         30         40         50         60 
MQNEIKKVCV IGAGVMGSGI AALIANSSHQ VVLLDILDKD SNDPNKIVKN SVKNLHKQKL 

        70         80         90        100        110        120 
SPLSFPDKVN FITIGNLEHD LDLIKECNLV IEVIVEKLEI KHQLYNKIIP YLKEDAIIAS 

       130        140        150        160        170        180 
NTSTLPLKKL KVNLPNNIKS RFVITHFFNP PRYMELVELI IDHTIKDEVI EKVSVFLTKM 

       190        200        210        220        230        240 
LGKTIIKCND TPGFIANRVG CFLLELVVHK AIAQNLNFVT IDQIFSRCLG LPNTGIFGLY 

       250        260        270        280        290        300 
DLIGHDVMKL ISSSLISALP KSDDYHRIYT NTKVFDKMIE HNLIGRKGEG GFYRLSVSNG 

       310        320        330        340        350        360 
KKIKEVINIS DLSYHPVQKV DISFNSLNEL LSSNSIYGKF FSEIITEFYI YLTSLVPSVT 

       370        380        390        400        410        420 
NNIYDIDTTM KLGYSWHYGP FELLTIAVKN GWNLIIKNAD LMNIPLPKYL ASKEYQKIDK 

       430        440        450        460        470        480 
QKFNSKKDFL QESKIVLSND SANLIHYCEN LVFVITTKMN SLNHNVFYLL QEAVSKAENY 

       490        500        510        520        530        540 
GKNLYIYPQG NNFSAGADLK LILSYIQDGN FHNLENLLKL GQQTMRYLKY SSVHIISCAR 

       550        560        570        580        590        600 
GVALGGGCEL LLNSSYIVAN QELNAGLIEL GVGLIPGWTG VTEMFARSNG NKTKLIRNIK 

       610        620        630        640        650        660 
NIIEQNKTSS ADYFKADYGI KNMQVNMNKH YILDDALKLR ISKKIVSIPN KITLPKINIV 

       670        680        690        700        710        720 
SEIDTSKYNE LQNKVLNKFQ NIIDKHNEIS EAELLTYERE MFLELAKTPQ TIEKLQAIVG 

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References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235272 Genomic DNA. Translation: CAA15008.1.
PIRF71660.
RefSeqNP_220931.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZCZ1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP560.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA15008; CAA15008; CAA15008.
GeneID883251.
KEGGrpr:RP560.
PATRIC17901919. VBIRicPro72556_0573.

Phylogenomic databases

eggNOGCOG1250.
HOGENOMHOG000264370.
KOK01782.
OMACKAVEGA.
OrthoDBEOG6B8XF5.
ProtClustDBCLSK870987.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR001753. Crotonase_core_superfam.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 2 hits.
ProtoNetSearch...

Entry information

Entry nameFAD3_RICPR
AccessionPrimary (citable) accession number: Q9ZCZ1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names