ID   NTRXL_RICPR             Reviewed;         475 AA.
AC   Q9ZCY9;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   27-MAR-2024, entry version 132.
DE   RecName: Full=Putative response regulator NtrX-like;
GN   OrderedLocusNames=RP562;
OS   Rickettsia prowazekii (strain Madrid E).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=272947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Madrid E;
RX   PubMed=9823893; DOI=10.1038/24094;
RA   Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T.,
RA   Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H.,
RA   Kurland C.G.;
RT   "The genome sequence of Rickettsia prowazekii and the origin of
RT   mitochondria.";
RL   Nature 396:133-140(1998).
CC   -!- FUNCTION: Member of the two-component regulatory system RP562/RP614.
CC       {ECO:0000250}.
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DR   EMBL; AJ235272; CAA15010.1; -; Genomic_DNA.
DR   PIR; H71660; H71660.
DR   RefSeq; NP_220934.1; NC_000963.1.
DR   RefSeq; WP_004599035.1; NC_000963.1.
DR   AlphaFoldDB; Q9ZCY9; -.
DR   SMR; Q9ZCY9; -.
DR   STRING; 272947.gene:17555642; -.
DR   EnsemblBacteria; CAA15010; CAA15010; CAA15010.
DR   GeneID; 57569686; -.
DR   KEGG; rpr:RP562; -.
DR   PATRIC; fig|272947.5.peg.578; -.
DR   eggNOG; COG2204; Bacteria.
DR   HOGENOM; CLU_000445_0_6_5; -.
DR   OrthoDB; 9802388at2; -.
DR   Proteomes; UP000002480; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd17550; REC_NtrX-like; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR002197; HTH_Fis.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR002078; Sigma_54_int.
DR   InterPro; IPR025944; Sigma_54_int_dom_CS.
DR   PANTHER; PTHR32071:SF17; TRANSCRIPTIONAL REGULATOR (NTRC FAMILY); 1.
DR   PANTHER; PTHR32071; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR   Pfam; PF02954; HTH_8; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00158; Sigma54_activat; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; CheY-like; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
DR   PROSITE; PS00688; SIGMA54_INTERACT_3; 1.
DR   PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..475
FT                   /note="Putative response regulator NtrX-like"
FT                   /id="PRO_0000282384"
FT   DOMAIN          5..121
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          143..369
FT                   /note="Sigma-54 factor interaction"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT   BINDING         171..178
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT   BINDING         232..241
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT   MOD_RES         54
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   475 AA;  53918 MW;  FE22277175CE5D05 CRC64;
     MSQLDVLIVD DEESIRNLIA ANLKDEGFNP KIAANSTQAL KIISEKPVSA VILDIWLQGS
     EIDGLGVLEI IKKRYPLMPV IIISGHGTIE TAVNAIKMGA YDYIEKPFNN DKLIILLKRA
     CEVTKLKREN IDLKSKVIDK TELVGGCPVT LKYKMEIEKA ASSSSRIMIH GKVGSGKELA
     ARLIHKQSKR VNNPFIIFSP TCMTTEKINQ ELFGESEKQE NNNKRPTILE FANNGTLYID
     EISNIPIPIQ VKLLKFLKDQ TITKPCGKKT KVDIKIITST AKNIQDEVNN GKFLEDLYYR
     LNVFSLKVPS LYERKEDIPL LVKYFVKQLS KFSGLKERHF SDEAIAALQS YEWPGNIRQL
     RNVVEWTLIM NPLTTGNNEI IKPYMIPSEI LANSANLTKL EDSFDMLSMP LREAREVFER
     QYLSAQMSRF NNNISKTSSF VGMERSALHR KLKLLSLHIP PTNRINEEEY EKANA
//