Q9ZCY9 (NTRXL_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative response regulator NtrX-like

Gene names

Ordered Locus Names:

RP562

Organism

Rickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia prowazekii

Protein attributes

Sequence length	475 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Member of the two-component regulatory system RP562/RP614 By similarity.
Sequence similarities	Contains 1 response regulatory domain. Contains 1 sigma-54 factor interaction domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Two-component regulatory system
Ligand	ATP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: GOC transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro phosphorelay response regulator activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 475	475	Putative response regulator NtrX-like		PRO_0000282384
Regions
	Domain	5 – 121	117	Response regulatory
	Domain	143 – 369	227	Sigma-54 factor interaction
	Nucleotide binding	171 – 178	8	ATP Potential
	Nucleotide binding	232 – 241	10	ATP Potential
Amino acid modifications
	Modified residue	54	1	4-aspartylphosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZCY9 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: FE22277175CE5D05	FASTA	475	53,918
	10 20 30 40 50 60 MSQLDVLIVD DEESIRNLIA ANLKDEGFNP KIAANSTQAL KIISEKPVSA VILDIWLQGS 70 80 90 100 110 120 EIDGLGVLEI IKKRYPLMPV IIISGHGTIE TAVNAIKMGA YDYIEKPFNN DKLIILLKRA 130 140 150 160 170 180 CEVTKLKREN IDLKSKVIDK TELVGGCPVT LKYKMEIEKA ASSSSRIMIH GKVGSGKELA 190 200 210 220 230 240 ARLIHKQSKR VNNPFIIFSP TCMTTEKINQ ELFGESEKQE NNNKRPTILE FANNGTLYID 250 260 270 280 290 300 EISNIPIPIQ VKLLKFLKDQ TITKPCGKKT KVDIKIITST AKNIQDEVNN GKFLEDLYYR 310 320 330 340 350 360 LNVFSLKVPS LYERKEDIPL LVKYFVKQLS KFSGLKERHF SDEAIAALQS YEWPGNIRQL 370 380 390 400 410 420 RNVVEWTLIM NPLTTGNNEI IKPYMIPSEI LANSANLTKL EDSFDMLSMP LREAREVFER 430 440 450 460 470 QYLSAQMSRF NNNISKTSSF VGMERSALHR KLKLLSLHIP PTNRINEEEY EKANA

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235272 Genomic DNA. Translation: CAA15010.1.
PIR	H71660.
RefSeq	NP_220934.1. NC_000963.1.
3D structure databases
HSSP	HSSP built from PDB template 1ZIT based on UniProtKB O66551.
ProteinModelPortal	Q9ZCY9.
ModBase	Search...
Protein-protein interaction databases
STRING	272947.RP562.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAA15010; CAA15010; CAA15010.
GeneID	883256.
KEGG	rpr:RP562.
PATRIC	17901929. VBIRicPro72556_0578.
Phylogenomic databases
eggNOG	COG2204.
HOGENOM	HOG000058489.
KO	K13599.
OMA	VAPTEAW.
ProtClustDB	CLSK870988.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR003593. AAA+_ATPase. IPR011006. CheY-like_superfamily. IPR009057. Homeodomain-like. IPR002197. HTH_Fis. IPR001789. Sig_transdc_resp-reg_receiver. IPR002078. Sigma_54_int. IPR025944. Sigma_54_int_dom_CS. [Graphical view]
Pfam	PF02954. HTH_8. 1 hit. PF00072. Response_reg. 1 hit. PF00158. Sigma54_activat. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. SM00448. REC. 1 hit. [Graphical view]
SUPFAM	SSF52172. CheY_like. 1 hit. SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS50110. RESPONSE_REGULATORY. 1 hit. PS00675. SIGMA54_INTERACT_1. False negative. PS00676. SIGMA54_INTERACT_2. False negative. PS00688. SIGMA54_INTERACT_3. 1 hit. PS50045. SIGMA54_INTERACT_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NTRXL_RICPR

Accession

Primary (citable) accession number: Q9ZCY9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program