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Q9ZCX9 (UVRC_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UvrABC system protein C

Short name=Protein UvrC
Alternative name(s):
Excinuclease ABC subunit C
Gene names
Name:uvrC
Ordered Locus Names:RP572
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length626 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity. HAMAP-Rule MF_00203

Subunit structure

Interacts with UvrB in an incision complex By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00203.

Sequence similarities

Belongs to the UvrC family.

Contains 1 GIY-YIG domain.

Contains 1 UVR domain.

Ontologies

Keywords
   Biological processDNA damage
DNA excision
DNA repair
SOS response
   Cellular componentCytoplasm
   Molecular functionExcision nuclease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processSOS response

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleotide-excision repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

excinuclease repair complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

excinuclease ABC activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 626626UvrABC system protein C HAMAP-Rule MF_00203
PRO_0000138332

Regions

Domain20 – 9778GIY-YIG
Domain207 – 24236UVR

Sequences

Sequence LengthMass (Da)Tools
Q9ZCX9 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: AD2EFDD005092397

FASTA62671,787
        10         20         30         40         50         60 
MSLEISGSKL IKAQIIDAPE CSGVYKMLDV NKQVIYIGKA KILKKRLTNY IKSDLDNKTL 

        70         80         90        100        110        120 
RMISNTYFLE YIITNSEVEA LLLEAQLIKK FQPKFNILLK DDKSFPFIKL SLDHDFPQLI 

       130        140        150        160        170        180 
KYRGKALSDG KFFGPFASNT QVNTTLTELQ KIFKLRSCTD NYFNSRTRPC LQYEIKRCYA 

       190        200        210        220        230        240 
PCVGKINKED YRELVMQVKD FLQCRTIALQ ANLSKKMQEL SSQMRFEEAA EIRDRIKALS 

       250        260        270        280        290        300 
YVQLKSGILD VVRDADIIAI VHKNLHYCIE VSLYRAGQPY GAIPYFFSST ENSTHEEVLE 

       310        320        330        340        350        360 
YFLLQFYQKQ QVPSEIIMNH EINSKENMIE AIKKINNISD LSITVPHKGG KAKLVQKAEV 

       370        380        390        400        410        420 
NALLSLEQYL KKSIKNTDIM FALKKLFDLP EIPERIEIYD NSHLQGMFAV GVMVVAGQIG 

       430        440        450        460        470        480 
FDKKEYRVFS LSSRSLTIGS EIELRDDRKG DDYGMLRQVL TRRFTRLKNE PHKLPSLMII 

       490        500        510        520        530        540 
DGGKGHLTIV KEVMDKFEIN IPFVCMSKGR DRNAGLEQLH MQGKEVLTLD KNLPIMKYLQ 

       550        560        570        580        590        600 
ILRDEAHNFA IKNHRLGRSR AIKISSLDEI DGIGETRKTA LLHYFGSYKA VCNATIDELT 

       610        620 
KVKGISKSLA SMIFNILNRK ISLDNS 

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235272 Genomic DNA. Translation: CAA15020.1.
PIRB71662.
RefSeqNP_220944.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZCX9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP572.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA15020; CAA15020; CAA15020.
GeneID883275.
KEGGrpr:RP572.
PATRIC17901951. VBIRicPro72556_0589.

Phylogenomic databases

eggNOGCOG0322.
HOGENOMHOG000279961.
KOK03703.
OMAQKLFPIR.
OrthoDBEOG6K13R9.
ProtClustDBPRK00558.

Family and domain databases

Gene3D3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPMF_00203. UvrC.
InterProIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsTIGR00194. uvrC. 1 hit.
PROSITEPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUVRC_RICPR
AccessionPrimary (citable) accession number: Q9ZCX9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names