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Q9ZCX3

- MURA_RICPR

UniProt

Q9ZCX3 - MURA_RICPR

Protein

UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Gene

murA

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.UniRule annotation

    Catalytic activityi

    Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei119 – 1191Proton donorUniRule annotation

    GO - Molecular functioni

    1. UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    4. regulation of cell shape Source: UniProtKB-KW
    5. UDP-N-acetylgalactosamine biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Keywords - Ligandi

    Pyruvate

    Enzyme and pathway databases

    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylglucosamine 1-carboxyvinyltransferaseUniRule annotation (EC:2.5.1.7UniRule annotation)
    Alternative name(s):
    Enoylpyruvate transferaseUniRule annotation
    UDP-N-acetylglucosamine enolpyruvyl transferaseUniRule annotation
    Short name:
    EPTUniRule annotation
    Gene namesi
    Name:murAUniRule annotation
    Ordered Locus Names:RP579
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 419419UDP-N-acetylglucosamine 1-carboxyvinyltransferasePRO_0000178910Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei119 – 11912-(S-cysteinyl)pyruvic acid O-phosphothioketalUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi272947.RP579.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZCX3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the EPSP synthase family. MurA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0766.
    HOGENOMiHOG000075602.
    KOiK00790.
    OMAiHGLEQMG.
    OrthoDBiEOG68M4GK.

    Family and domain databases

    Gene3Di3.65.10.10. 2 hits.
    HAMAPiMF_00111. MurA.
    InterProiIPR001986. Enolpyruvate_Tfrase_dom.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    IPR005750. UDP_GlcNAc_COvinyl_MurA.
    [Graphical view]
    PANTHERiPTHR21090:SF4. PTHR21090:SF4. 1 hit.
    PfamiPF00275. EPSP_synthase. 1 hit.
    [Graphical view]
    SUPFAMiSSF55205. SSF55205. 1 hit.
    TIGRFAMsiTIGR01072. murA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZCX3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKLIIHGGK PLEGSINISG AKNAVLPIMA ASILTNKLHI TNVPKLTDVS    50
    TMKDLLRNHG ACIRIIEHTD EFELIINTTN INKFTADYEI VRKMRASIWV 100
    LGPLLTKYGK AKVSLPGGCA IGARQVDLHI AVLKSMGAEI EIEDGYINAS 150
    SKGRLKGTHF IFDKVSVGAT INAILAAVLA KGETVLFNCG REPEIVDLCY 200
    CLIKMGADIL GVGSSTITIK GKDCLNETSY KVLSDRIEAG TYMFAAAITK 250
    GDVKICGIDY NIIENIALKL IETGIKVVQI NNGVQVTYKG KLNSVDLETN 300
    PYPGFATDLQ AQFMSLMSIS SGVSMITENI FENRFMHVPE LCRMGADIVV 350
    RGNKAVVRGV EMLKGAEVMA SDLRASVSLI LAGLSTNSKT VLHRIYHLDR 400
    GFQDLEKKLS NCGANIKRV 419
    Length:419
    Mass (Da):45,472
    Last modified:May 1, 1999 - v1
    Checksum:i1CAA8684C48E9157
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235272 Genomic DNA. Translation: CAA15026.1.
    PIRiH71662.
    RefSeqiNP_220950.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA15026; CAA15026; CAA15026.
    GeneIDi883843.
    KEGGirpr:RP579.
    PATRICi17901967. VBIRicPro72556_0596.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235272 Genomic DNA. Translation: CAA15026.1 .
    PIRi H71662.
    RefSeqi NP_220950.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZCX3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP579.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA15026 ; CAA15026 ; CAA15026 .
    GeneIDi 883843.
    KEGGi rpr:RP579.
    PATRICi 17901967. VBIRicPro72556_0596.

    Phylogenomic databases

    eggNOGi COG0766.
    HOGENOMi HOG000075602.
    KOi K00790.
    OMAi HGLEQMG.
    OrthoDBi EOG68M4GK.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .

    Family and domain databases

    Gene3Di 3.65.10.10. 2 hits.
    HAMAPi MF_00111. MurA.
    InterProi IPR001986. Enolpyruvate_Tfrase_dom.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    IPR005750. UDP_GlcNAc_COvinyl_MurA.
    [Graphical view ]
    PANTHERi PTHR21090:SF4. PTHR21090:SF4. 1 hit.
    Pfami PF00275. EPSP_synthase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55205. SSF55205. 1 hit.
    TIGRFAMsi TIGR01072. murA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiMURA_RICPR
    AccessioniPrimary (citable) accession number: Q9ZCX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3