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Q9ZCX3 (MURA_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase

EC=2.5.1.7
Alternative name(s):
Enoylpyruvate transferase
UDP-N-acetylglucosamine enolpyruvyl transferase
Short name=EPT
Gene names
Name:murA
Ordered Locus Names:RP579
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. HAMAP-Rule MF_00111

Catalytic activity

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine. HAMAP-Rule MF_00111

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00111

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00111.

Sequence similarities

Belongs to the EPSP synthase family. MurA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 419419UDP-N-acetylglucosamine 1-carboxyvinyltransferase HAMAP-Rule MF_00111
PRO_0000178910

Sites

Active site1191Proton donor By similarity

Amino acid modifications

Modified residue11912-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZCX3 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 1CAA8684C48E9157

FASTA41945,472
        10         20         30         40         50         60 
MQKLIIHGGK PLEGSINISG AKNAVLPIMA ASILTNKLHI TNVPKLTDVS TMKDLLRNHG 

        70         80         90        100        110        120 
ACIRIIEHTD EFELIINTTN INKFTADYEI VRKMRASIWV LGPLLTKYGK AKVSLPGGCA 

       130        140        150        160        170        180 
IGARQVDLHI AVLKSMGAEI EIEDGYINAS SKGRLKGTHF IFDKVSVGAT INAILAAVLA 

       190        200        210        220        230        240 
KGETVLFNCG REPEIVDLCY CLIKMGADIL GVGSSTITIK GKDCLNETSY KVLSDRIEAG 

       250        260        270        280        290        300 
TYMFAAAITK GDVKICGIDY NIIENIALKL IETGIKVVQI NNGVQVTYKG KLNSVDLETN 

       310        320        330        340        350        360 
PYPGFATDLQ AQFMSLMSIS SGVSMITENI FENRFMHVPE LCRMGADIVV RGNKAVVRGV 

       370        380        390        400        410 
EMLKGAEVMA SDLRASVSLI LAGLSTNSKT VLHRIYHLDR GFQDLEKKLS NCGANIKRV 

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235272 Genomic DNA. Translation: CAA15026.1.
PIRH71662.
RefSeqNP_220950.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZCX3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP579.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA15026; CAA15026; CAA15026.
GeneID883843.
KEGGrpr:RP579.
PATRIC17901967. VBIRicPro72556_0596.

Phylogenomic databases

eggNOGCOG0766.
HOGENOMHOG000075602.
KOK00790.
OMAHGLEQMG.
OrthoDBEOG68M4GK.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.65.10.10. 2 hits.
HAMAPMF_00111. MurA.
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMSSF55205. SSF55205. 1 hit.
TIGRFAMsTIGR01072. murA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURA_RICPR
AccessionPrimary (citable) accession number: Q9ZCX3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways