Q9ZCW8 (SECD_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein translocase subunit SecD

Gene names

Name:	secD
Ordered Locus Names:	RP586

Organism

Rickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia prowazekii

Protein attributes

Sequence length	518 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA By similarity. HAMAP-Rule MF_01463
Subunit structure	Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01463.
Sequence similarities	Belongs to the SecD/SecF family. SecD subfamily.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular protein transmembrane transport Inferred from electronic annotation. Source: HAMAP protein targeting Inferred from electronic annotation. Source: HAMAP protein transport by the Sec complex Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	P-P-bond-hydrolysis-driven protein transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 518	518	Protein translocase subunit SecD HAMAP-Rule MF_01463		PRO_0000095968
Regions
	Transmembrane	9 – 29	21	Helical; Potential
	Transmembrane	356 – 376	21	Helical; Potential
	Transmembrane	377 – 397	21	Helical; Potential
	Transmembrane	406 – 426	21	Helical; Potential
	Transmembrane	463 – 483	21	Helical; Potential
	Transmembrane	486 – 506	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZCW8 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 86D6FC2A5B5DE2AA	FASTA	518	56,712
	10 20 30 40 50 60 MQNLPKWKIV LSIICTVFAI ICALPNFIQI NSKFLPHDSI NLGLDLRGGA NLLLDVDFDT 70 80 90 100 110 120 YLNDSMENLA DTLRKNLRKH KIGYKNLLVR HNNIQLEVRS PEVLKSLKKI INKIDPEIII 130 140 150 160 170 180 GVNKNKIKLR YSESRFNDLL NKVVEQSIEI VRMRVDSTGT KEPTLQRQGN KHILLQVPGS 190 200 210 220 230 240 ENPSYLKNIL GKTAKLTFHL VDENANIEDA IKGHVPLGSM LIKGDSKHHG EYYIVIKKKV 250 260 270 280 290 300 LLSGAHLTKA SASFDQNSQP IVAFSFNNLG SKIFGEITKN NTGKRLAIVL DNKLLSAPII 310 320 330 340 350 360 NGAIIGGNGI ITGNFTIESA NELALLLRVG SLPTPLKIIE ERSIGPNLGA DSIESGKKAG 370 380 390 400 410 420 LIGFVAVCIF MILSYGVIGL FANIALILAL LYILALLSLF QATLTLPGIA GIILTIGMAV 430 440 450 460 470 480 DANVLIYERI KEELHKGVSN LYAIRTGFES AFATIIDSNI TTLIVAFALY IFGVGAIKGF 490 500 510 AVALTIGIIS SMFSAIIITK LLIDVWVKYF KPKKLGLL

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235272 Genomic DNA. Translation: CAA15031.1.
PIR	E71663.
RefSeq	NP_220955.1. NC_000963.1.
3D structure databases
ProteinModelPortal	Q9ZCW8.
ModBase	Search...
Protein-protein interaction databases
STRING	272947.RP586.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAA15031; CAA15031; CAA15031.
GeneID	883986.
KEGG	rpr:RP586.
PATRIC	17901983. VBIRicPro72556_0602.
Phylogenomic databases
eggNOG	COG0342.
HOGENOM	HOG000018636.
KO	K03072.
OMA	VNLWYGR.
ProtClustDB	PRK05812.
Family and domain databases
HAMAP	MF_01463_B. SecD_B.
InterPro	IPR005791. SecD. IPR022813. SecD/SecF. IPR022645. SecD/SecF_bac. IPR022646. SecD/SecF_CS. [Graphical view]
Pfam	PF07549. Sec_GG. 1 hit. PF02355. SecD_SecF. 1 hit. [Graphical view]
TIGRFAMs	TIGR00916. 2A0604s01. 1 hit. TIGR01129. secD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SECD_RICPR

Accession

Primary (citable) accession number: Q9ZCW8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program