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Q9ZCW6

- CCME_RICPR

UniProt

Q9ZCW6 - CCME_RICPR

Protein

Cytochrome c-type biogenesis protein CcmE

Gene

ccmE

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei120 – 1201Heme (covalent; via pros nitrogen)UniRule annotation
    Metal bindingi124 – 1241Iron (heme axial ligand)UniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cytochrome complex assembly Source: UniProtKB-KW
    2. protein-heme linkage Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Cytochrome c-type biogenesis

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c-type biogenesis protein CcmEUniRule annotation
    Alternative name(s):
    Cytochrome c maturation protein EUniRule annotation
    Heme chaperone CcmEUniRule annotation
    Gene namesi
    Name:ccmEUniRule annotation
    Synonyms:cycJUniRule annotation
    Ordered Locus Names:RP588
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Single-pass type II membrane protein UniRule annotation; Periplasmic side UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 128128Cytochrome c-type biogenesis protein CcmEPRO_0000238857Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272947.RP588.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZCW6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 88CytoplasmicUniRule annotation
    Topological domaini30 – 12899PeriplasmicUniRule annotationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921Helical; Signal-anchor for type II membrane proteinUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CcmE/CycJ family.UniRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2332.
    HOGENOMiHOG000009661.
    KOiK02197.
    OMAiENYMPRE.
    OrthoDBiEOG69D3JN.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_01959. CcmE.
    InterProiIPR004329. CcmE.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF03100. CcmE. 1 hit.
    [Graphical view]
    SUPFAMiSSF82093. SSF82093. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZCW6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKIVRNRLI KIIICFCSAC LGISIILYNL EKNIIFFFPP SKINEAEQGK    50
    ELRVGGLVKR DSINKISANK ISFVITDNIK DLEILYQGVL PALFREGQGI 100
    IAIGQLSDSK FIARQLLAKH DENYRPPS 128
    Length:128
    Mass (Da):14,447
    Last modified:May 1, 1999 - v1
    Checksum:iF2EC6EA781B68249
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235272 Genomic DNA. Translation: CAA15033.1.
    PIRiG71663.
    RefSeqiNP_220957.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA15033; CAA15033; CAA15033.
    GeneIDi883906.
    KEGGirpr:RP588.
    PATRICi17901989. VBIRicPro72556_0605.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235272 Genomic DNA. Translation: CAA15033.1 .
    PIRi G71663.
    RefSeqi NP_220957.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZCW6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP588.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA15033 ; CAA15033 ; CAA15033 .
    GeneIDi 883906.
    KEGGi rpr:RP588.
    PATRICi 17901989. VBIRicPro72556_0605.

    Phylogenomic databases

    eggNOGi COG2332.
    HOGENOMi HOG000009661.
    KOi K02197.
    OMAi ENYMPRE.
    OrthoDBi EOG69D3JN.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_01959. CcmE.
    InterProi IPR004329. CcmE.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF03100. CcmE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF82093. SSF82093. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiCCME_RICPR
    AccessioniPrimary (citable) accession number: Q9ZCW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3