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Protein

Cytochrome c-type biogenesis protein CcmE

Gene

ccmE

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei120Heme (covalent; via pros nitrogen)UniRule annotation1
Metal bindingi124Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCytochrome c-type biogenesis
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciRPRO272947:G1GT0-589-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type biogenesis protein CcmEUniRule annotation
Alternative name(s):
Cytochrome c maturation protein EUniRule annotation
Heme chaperone CcmEUniRule annotation
Gene namesi
Name:ccmEUniRule annotation
Synonyms:cycJUniRule annotation
Ordered Locus Names:RP588
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000002480 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass type II membrane protein UniRule annotation; Periplasmic side UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicUniRule annotation8
Transmembranei9 – 29Helical; Signal-anchor for type II membrane proteinUniRule annotationAdd BLAST21
Topological domaini30 – 128PeriplasmicUniRule annotationAdd BLAST99

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002388571 – 128Cytochrome c-type biogenesis protein CcmEAdd BLAST128

Interactioni

Protein-protein interaction databases

STRINGi272947.RP588

Structurei

3D structure databases

ProteinModelPortaliQ9ZCW6
SMRiQ9ZCW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CcmE/CycJ family.UniRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108ZKK Bacteria
COG2332 LUCA
HOGENOMiHOG000009661
KOiK02197
OMAiGPDQNVE

Family and domain databases

HAMAPiMF_01959 CcmE, 1 hit
InterProiView protein in InterPro
IPR004329 CcmE
IPR036127 CcmE-like_sf
PANTHERiPTHR34128 PTHR34128, 1 hit
PfamiView protein in Pfam
PF03100 CcmE, 1 hit
SUPFAMiSSF82093 SSF82093, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZCW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKIVRNRLI KIIICFCSAC LGISIILYNL EKNIIFFFPP SKINEAEQGK
60 70 80 90 100
ELRVGGLVKR DSINKISANK ISFVITDNIK DLEILYQGVL PALFREGQGI
110 120
IAIGQLSDSK FIARQLLAKH DENYRPPS
Length:128
Mass (Da):14,447
Last modified:May 1, 1999 - v1
Checksum:iF2EC6EA781B68249
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235272 Genomic DNA Translation: CAA15033.1
PIRiG71663
RefSeqiNP_220957.1, NC_000963.1
WP_004597913.1, NC_000963.1

Genome annotation databases

EnsemblBacteriaiCAA15033; CAA15033; CAA15033
GeneIDi883906
KEGGirpr:RP588
PATRICifig|272947.5.peg.605

Similar proteinsi

Entry informationi

Entry nameiCCME_RICPR
AccessioniPrimary (citable) accession number: Q9ZCW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health