Q9ZCW6 (CCME_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c-type biogenesis protein CcmE

Alternative name(s):
Cytochrome c maturation protein E
Heme chaperone CcmE

Gene names

Name:	ccmE
Synonyms:	cycJ
Ordered Locus Names:	RP588

Organism

Rickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia prowazekii

Protein attributes

Sequence length	128 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH By similarity. HAMAP-Rule MF_01959
Subcellular location	Cell inner membrane; Single-pass type II membrane protein; Periplasmic side Potential HAMAP-Rule MF_01959.
Sequence similarities	Belongs to the CcmE/CycJ family.

Ontologies

Keywords
Biological process	Cytochrome c-type biogenesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cytochrome complex assembly Inferred from electronic annotation. Source: UniProtKB-KW protein-heme linkage Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 128	128	Cytochrome c-type biogenesis protein CcmE HAMAP-Rule MF_01959		PRO_0000238857
Regions
	Topological domain	1 – 8	8	Cytoplasmic Potential
	Transmembrane	9 – 29	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	30 – 128	99	Periplasmic Potential
Sites
	Metal binding	124	1	Iron (heme axial ligand) By similarity
	Binding site	120	1	Heme (covalent; via pros nitrogen) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZCW6 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: F2EC6EA781B68249	FASTA	128	14,447
	10 20 30 40 50 60 MQKIVRNRLI KIIICFCSAC LGISIILYNL EKNIIFFFPP SKINEAEQGK ELRVGGLVKR 70 80 90 100 110 120 DSINKISANK ISFVITDNIK DLEILYQGVL PALFREGQGI IAIGQLSDSK FIARQLLAKH DENYRPPS

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235272 Genomic DNA. Translation: CAA15033.1.
PIR	G71663.
RefSeq	NP_220957.1. NC_000963.1.
3D structure databases
ProteinModelPortal	Q9ZCW6.
ModBase	Search...
Protein-protein interaction databases
STRING	272947.RP588.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAA15033; CAA15033; CAA15033.
GeneID	883906.
KEGG	rpr:RP588.
PATRIC	17901989. VBIRicPro72556_0605.
Phylogenomic databases
eggNOG	COG2332.
HOGENOM	HOG000009661.
KO	K02197.
OMA	ICFCSAC.
ProtClustDB	PRK13254.
Family and domain databases
Gene3D	2.40.50.140. 1 hit.
HAMAP	MF_01959. CcmE.
InterPro	IPR004329. CcmE. IPR012340. NA-bd_OB-fold. [Graphical view]
Pfam	PF03100. CcmE. 1 hit. [Graphical view]
SUPFAM	SSF82093. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CCME_RICPR

Accession

Primary (citable) accession number: Q9ZCW6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program