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Q9ZCW6 (CCME_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c-type biogenesis protein CcmE
Alternative name(s):
Cytochrome c maturation protein E
Heme chaperone CcmE
Gene names
Name:ccmE
Synonyms:cycJ
Ordered Locus Names:RP588
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length128 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH By similarity. HAMAP-Rule MF_01959

Subcellular location

Cell inner membrane; Single-pass type II membrane protein; Periplasmic side Potential HAMAP-Rule MF_01959.

Sequence similarities

Belongs to the CcmE/CycJ family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 128128Cytochrome c-type biogenesis protein CcmE HAMAP-Rule MF_01959
PRO_0000238857

Regions

Topological domain1 – 88Cytoplasmic Potential
Transmembrane9 – 2921Helical; Signal-anchor for type II membrane protein; Potential
Topological domain30 – 12899Periplasmic Potential

Sites

Metal binding1241Iron (heme axial ligand) By similarity
Binding site1201Heme (covalent; via pros nitrogen) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZCW6 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: F2EC6EA781B68249

FASTA12814,447
        10         20         30         40         50         60 
MQKIVRNRLI KIIICFCSAC LGISIILYNL EKNIIFFFPP SKINEAEQGK ELRVGGLVKR 

        70         80         90        100        110        120 
DSINKISANK ISFVITDNIK DLEILYQGVL PALFREGQGI IAIGQLSDSK FIARQLLAKH 


DENYRPPS 

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235272 Genomic DNA. Translation: CAA15033.1.
PIRG71663.
RefSeqNP_220957.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZCW6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP588.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA15033; CAA15033; CAA15033.
GeneID883906.
KEGGrpr:RP588.
PATRIC17901989. VBIRicPro72556_0605.

Phylogenomic databases

eggNOGCOG2332.
HOGENOMHOG000009661.
KOK02197.
OMAGPDQNVE.
OrthoDBEOG69D3JN.
ProtClustDBPRK13254.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
HAMAPMF_01959. CcmE.
InterProIPR004329. CcmE.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF03100. CcmE. 1 hit.
[Graphical view]
SUPFAMSSF82093. SSF82093. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCCME_RICPR
AccessionPrimary (citable) accession number: Q9ZCW6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names