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Q9ZCW6

- CCME_RICPR

UniProt

Q9ZCW6 - CCME_RICPR

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Protein

Cytochrome c-type biogenesis protein CcmE

Gene
ccmE, cycJ, RP588
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201Heme (covalent; via pros nitrogen) By similarity
Metal bindingi124 – 1241Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cytochrome complex assembly Source: UniProtKB-KW
  2. protein-heme linkage Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Cytochrome c-type biogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type biogenesis protein CcmE
Alternative name(s):
Cytochrome c maturation protein E
Heme chaperone CcmE
Gene namesi
Name:ccmE
Synonyms:cycJ
Ordered Locus Names:RP588
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88Cytoplasmic Reviewed prediction
Transmembranei9 – 2921Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini30 – 12899Periplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 128128Cytochrome c-type biogenesis protein CcmEUniRule annotationPRO_0000238857Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272947.RP588.

Structurei

3D structure databases

ProteinModelPortaliQ9ZCW6.

Family & Domainsi

Sequence similaritiesi

Belongs to the CcmE/CycJ family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2332.
HOGENOMiHOG000009661.
KOiK02197.
OMAiENYMPRE.
OrthoDBiEOG69D3JN.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_01959. CcmE.
InterProiIPR004329. CcmE.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF03100. CcmE. 1 hit.
[Graphical view]
SUPFAMiSSF82093. SSF82093. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZCW6-1 [UniParc]FASTAAdd to Basket

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MQKIVRNRLI KIIICFCSAC LGISIILYNL EKNIIFFFPP SKINEAEQGK    50
ELRVGGLVKR DSINKISANK ISFVITDNIK DLEILYQGVL PALFREGQGI 100
IAIGQLSDSK FIARQLLAKH DENYRPPS 128
Length:128
Mass (Da):14,447
Last modified:May 1, 1999 - v1
Checksum:iF2EC6EA781B68249
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235272 Genomic DNA. Translation: CAA15033.1.
PIRiG71663.
RefSeqiNP_220957.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA15033; CAA15033; CAA15033.
GeneIDi883906.
KEGGirpr:RP588.
PATRICi17901989. VBIRicPro72556_0605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235272 Genomic DNA. Translation: CAA15033.1 .
PIRi G71663.
RefSeqi NP_220957.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZCW6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP588.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA15033 ; CAA15033 ; CAA15033 .
GeneIDi 883906.
KEGGi rpr:RP588.
PATRICi 17901989. VBIRicPro72556_0605.

Phylogenomic databases

eggNOGi COG2332.
HOGENOMi HOG000009661.
KOi K02197.
OMAi ENYMPRE.
OrthoDBi EOG69D3JN.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
HAMAPi MF_01959. CcmE.
InterProi IPR004329. CcmE.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF03100. CcmE. 1 hit.
[Graphical view ]
SUPFAMi SSF82093. SSF82093. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiCCME_RICPR
AccessioniPrimary (citable) accession number: Q9ZCW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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