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Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.UniRule annotation

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei29SubstrateUniRule annotation1
Binding sitei43SubstrateUniRule annotation1
Binding sitei55SubstrateUniRule annotation1
Metal bindingi65Magnesium 1UniRule annotation1
Metal bindingi70Magnesium 1UniRule annotation1
Metal bindingi70Magnesium 2UniRule annotation1
Metal bindingi102Magnesium 1UniRule annotation1
Binding sitei141SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaUniRule annotation
Ordered Locus Names:RP589
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000002480 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001375291 – 172Inorganic pyrophosphataseAdd BLAST172

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi272947.RP589.

Structurei

Secondary structure

1172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 5Combined sources3
Beta strandi15 – 21Combined sources7
Beta strandi27 – 32Combined sources6
Turni34 – 36Combined sources3
Beta strandi39 – 44Combined sources6
Beta strandi47 – 49Combined sources3
Beta strandi52 – 57Combined sources6
Beta strandi70 – 73Combined sources4
Beta strandi84 – 97Combined sources14
Beta strandi100 – 109Combined sources10
Turni111 – 113Combined sources3
Helixi115 – 117Combined sources3
Helixi123 – 125Combined sources3
Helixi128 – 140Combined sources13
Turni141 – 144Combined sources4
Beta strandi150 – 156Combined sources7
Helixi158 – 170Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D53X-ray2.20A/B/C/D/E/F1-172[»]
3EMJX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L1-172[»]
ProteinModelPortaliQ9ZCW5.
SMRiQ9ZCW5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ZCW5.

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
HOGENOMiHOG000236473.
KOiK01507.
OMAiHPEKYTF.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZCW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIKKIKAKA NNNEINVIIE IPMNSGPIKY EFDKESGALF VDRFMQTTMS
60 70 80 90 100
YPCNYGFIPD TLSNDGDPVD VLVVAHHPVV PGSVIKCRAI GVLMMEDESG
110 120 130 140 150
LDEKIIAVPT SKLDITFDHI KELDDLCEML KKRIVHFFEH YKDLEKGKWV
160 170
KVTGWGDKVK AETLIKEGID RN
Length:172
Mass (Da):19,515
Last modified:May 1, 1999 - v1
Checksum:i60248645842A13C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235272 Genomic DNA. Translation: CAA15034.1.
PIRiH71663.
RefSeqiNP_220958.1. NC_000963.1.
WP_004597914.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA15034; CAA15034; CAA15034.
GeneIDi883528.
KEGGirpr:RP589.
PATRICi17901991. VBIRicPro72556_0606.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235272 Genomic DNA. Translation: CAA15034.1.
PIRiH71663.
RefSeqiNP_220958.1. NC_000963.1.
WP_004597914.1. NC_000963.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D53X-ray2.20A/B/C/D/E/F1-172[»]
3EMJX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L1-172[»]
ProteinModelPortaliQ9ZCW5.
SMRiQ9ZCW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272947.RP589.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA15034; CAA15034; CAA15034.
GeneIDi883528.
KEGGirpr:RP589.
PATRICi17901991. VBIRicPro72556_0606.

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
HOGENOMiHOG000236473.
KOiK01507.
OMAiHPEKYTF.

Miscellaneous databases

EvolutionaryTraceiQ9ZCW5.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIPYR_RICPR
AccessioniPrimary (citable) accession number: Q9ZCW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.