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Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.

Cofactori

Mg2+By similarityNote: Binds 4 Mg2+ ions per subunit. Other metal ions can support activity, but at a lower rate. Two Mg2+ ions are required for the activation of the enzyme and are present before substrate binds, two additional Mg2+ ions form complexes with substrate and product.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi65 – 651Magnesium 1By similarity
Metal bindingi70 – 701Magnesium 1By similarity
Metal bindingi70 – 701Magnesium 2By similarity
Metal bindingi102 – 1021Magnesium 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphatase (EC:3.6.1.1)
Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name:
PPase
Gene namesi
Name:ppa
Ordered Locus Names:RP589
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000002480 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Inorganic pyrophosphatasePRO_0000137529Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272947.RP589.

Structurei

Secondary structure

1
172
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 53Combined sources
Beta strandi15 – 217Combined sources
Beta strandi27 – 326Combined sources
Turni34 – 363Combined sources
Beta strandi39 – 446Combined sources
Beta strandi47 – 493Combined sources
Beta strandi52 – 576Combined sources
Beta strandi70 – 734Combined sources
Beta strandi84 – 9714Combined sources
Beta strandi100 – 10910Combined sources
Turni111 – 1133Combined sources
Helixi115 – 1173Combined sources
Helixi123 – 1253Combined sources
Helixi128 – 14013Combined sources
Turni141 – 1444Combined sources
Beta strandi150 – 1567Combined sources
Helixi158 – 17013Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3D53X-ray2.20A/B/C/D/E/F1-172[»]
3EMJX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L1-172[»]
ProteinModelPortaliQ9ZCW5.
SMRiQ9ZCW5. Positions 2-172.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ZCW5.

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.Curated

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
HOGENOMiHOG000236473.
KOiK01507.
OMAiHPEKYTF.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZCW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIKKIKAKA NNNEINVIIE IPMNSGPIKY EFDKESGALF VDRFMQTTMS
60 70 80 90 100
YPCNYGFIPD TLSNDGDPVD VLVVAHHPVV PGSVIKCRAI GVLMMEDESG
110 120 130 140 150
LDEKIIAVPT SKLDITFDHI KELDDLCEML KKRIVHFFEH YKDLEKGKWV
160 170
KVTGWGDKVK AETLIKEGID RN
Length:172
Mass (Da):19,515
Last modified:May 1, 1999 - v1
Checksum:i60248645842A13C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235272 Genomic DNA. Translation: CAA15034.1.
PIRiH71663.
RefSeqiNP_220958.1. NC_000963.1.
WP_004597914.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA15034; CAA15034; CAA15034.
GeneIDi883528.
KEGGirpr:RP589.
PATRICi17901991. VBIRicPro72556_0606.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235272 Genomic DNA. Translation: CAA15034.1.
PIRiH71663.
RefSeqiNP_220958.1. NC_000963.1.
WP_004597914.1. NC_000963.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3D53X-ray2.20A/B/C/D/E/F1-172[»]
3EMJX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L1-172[»]
ProteinModelPortaliQ9ZCW5.
SMRiQ9ZCW5. Positions 2-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272947.RP589.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA15034; CAA15034; CAA15034.
GeneIDi883528.
KEGGirpr:RP589.
PATRICi17901991. VBIRicPro72556_0606.

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
HOGENOMiHOG000236473.
KOiK01507.
OMAiHPEKYTF.

Miscellaneous databases

EvolutionaryTraceiQ9ZCW5.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIPYR_RICPR
AccessioniPrimary (citable) accession number: Q9ZCW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.