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Q9ZCW0 (MRAY_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:RP595
OrganismRickettsia prowazekii (strain Madrid E)
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_0000108880

Regions

Transmembrane28 – 4821Helical; Potential
Transmembrane74 – 9421Helical; Potential
Transmembrane99 – 11921Helical; Potential
Transmembrane133 – 15321Helical; Potential
Transmembrane168 – 18821Helical; Potential
Transmembrane203 – 22321Helical; Potential
Transmembrane236 – 25621Helical; Potential
Transmembrane263 – 28321Helical; Potential
Transmembrane288 – 30821Helical; Potential
Transmembrane338 – 35821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9ZCW0 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: F67E3D997E573224

FASTA36140,033
        10         20         30         40         50         60 
MLYNLLLPHI HNSHIANLFH YITFRSGLAI IITLSISFVT GPILIKFLRS LQKYGQPIRS 

        70         80         90        100        110        120 
DGPESHKTKA GTPTMGGIMI ILSSCLSTLL LADLTNKYIW ITLFGFISFG IIGFMDDYAK 

       130        140        150        160        170        180 
VKRNNHYGVR GKSKFLLQGI ISLIIYVLLE YLDKNFSHLL NVPFFKNLSL DLNYFYMVFA 

       190        200        210        220        230        240 
IFVIVGSSNA VNLTDGLDGL ATVPIAFTAG SFALISYLVG NLIYANYLQL TYIPNTGELT 

       250        260        270        280        290        300 
VLCAGLVGSC LGFLWFNAQP AEVFMGDTGS LSLGGVLGII SVITKHEIVL AIIGGLFVIE 

       310        320        330        340        350        360 
TTSVILQVYY FKATKGKRIF KMAPLHHHFE KHGWAESKVV IRFWIISVIF SLIGLSSLKL 


R

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References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed: 9823893] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ235272 Genomic DNA. Translation: CAA15039.1.
PIRE71664.
RefSeqNP_220963.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZCW0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID883698.
GenomeReviewsGene locus RP595 in contig AJ235269_GR.
KEGGrpr:RP595.
PATRIC17902005. VBIRicPro72556_0613.

Phylogenomic databases

HOGENOMHBG708263.
OMARFWIISM.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycRPRO272947:RP595-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_RICPR
AccessionPrimary (citable) accession number: Q9ZCW0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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