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Q9ZCV4 (PTH_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-tRNA hydrolase

Short name=PTH
EC=3.1.1.29
Gene names
Name:pth
Ordered Locus Names:RP605
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length185 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP-Rule MF_00083

Catalytic activity

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP-Rule MF_00083

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00083

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00083.

Sequence similarities

Belongs to the PTH family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaminoacyl-tRNA hydrolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 185185Peptidyl-tRNA hydrolase HAMAP-Rule MF_00083
PRO_0000187805

Sequences

Sequence LengthMass (Da)Tools
Q9ZCV4 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 91835CC2A6912C6D

FASTA18521,007
        10         20         30         40         50         60 
MILVIGLGNP GTEYQYTRHN IGFIAIERIA SKYHLSFSIK KKFNCEIAEA VIDRQKIIFI 

        70         80         90        100        110        120 
KPTTYMNLSG KSVILVKTYY NIKYEKVFVI HDDIDLEIGR IKFKTGGGNG GHNGLKSIDV 

       130        140        150        160        170        180 
VIGNHYNRIR IGIGRPKNNH DVADYVLNNF SESEYKIAMQ SIDNIANNFG LILEHKLAEF 


TNKIV 

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235272 Genomic DNA. Translation: CAA15049.1.
PIRG71665.
RefSeqNP_220973.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZCV4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP605.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA15049; CAA15049; CAA15049.
GeneID883784.
KEGGrpr:RP605.
PATRIC17902027. VBIRicPro72556_0624.

Phylogenomic databases

eggNOGCOG0193.
HOGENOMHOG000004797.
KOK01056.
OMAAMHRLHS.
OrthoDBEOG6C5RTR.

Family and domain databases

Gene3D3.40.50.1470. 1 hit.
HAMAPMF_00083. Pept_tRNA_hydro_bact.
InterProIPR001328. Pept_tRNA_hydro.
IPR018171. Pept_tRNA_hydro_CS.
[Graphical view]
PANTHERPTHR17224. PTHR17224. 1 hit.
PfamPF01195. Pept_tRNA_hydro. 1 hit.
[Graphical view]
SUPFAMSSF53178. SSF53178. 1 hit.
TIGRFAMsTIGR00447. pth. 1 hit.
PROSITEPS01195. PEPT_TRNA_HYDROL_1. 1 hit.
PS01196. PEPT_TRNA_HYDROL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePTH_RICPR
AccessionPrimary (citable) accession number: Q9ZCV4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names