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Protein

Peptidyl-tRNA hydrolase

Gene

pth

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.UniRule annotation

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciRPRO272947:G1GT0-605-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-tRNA hydrolaseUniRule annotation (EC:3.1.1.29UniRule annotation)
Short name:
PTHUniRule annotation
Gene namesi
Name:pthUniRule annotation
Ordered Locus Names:RP605
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000002480 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001878051 – 185Peptidyl-tRNA hydrolaseAdd BLAST185

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi272947.RP605

Structurei

3D structure databases

ProteinModelPortaliQ9ZCV4
SMRiQ9ZCV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZPD Bacteria
COG0193 LUCA
HOGENOMiHOG000004797
KOiK01056
OMAiRYAHTRH

Family and domain databases

CDDicd00462 PTH, 1 hit
Gene3Di3.40.50.1470, 1 hit
HAMAPiMF_00083 Pept_tRNA_hydro_bact, 1 hit
InterProiView protein in InterPro
IPR001328 Pept_tRNA_hydro
IPR018171 Pept_tRNA_hydro_CS
IPR036416 Pept_tRNA_hydro_sf
PANTHERiPTHR17224 PTHR17224, 1 hit
PfamiView protein in Pfam
PF01195 Pept_tRNA_hydro, 1 hit
SUPFAMiSSF53178 SSF53178, 1 hit
TIGRFAMsiTIGR00447 pth, 1 hit
PROSITEiView protein in PROSITE
PS01195 PEPT_TRNA_HYDROL_1, 1 hit
PS01196 PEPT_TRNA_HYDROL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZCV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILVIGLGNP GTEYQYTRHN IGFIAIERIA SKYHLSFSIK KKFNCEIAEA
60 70 80 90 100
VIDRQKIIFI KPTTYMNLSG KSVILVKTYY NIKYEKVFVI HDDIDLEIGR
110 120 130 140 150
IKFKTGGGNG GHNGLKSIDV VIGNHYNRIR IGIGRPKNNH DVADYVLNNF
160 170 180
SESEYKIAMQ SIDNIANNFG LILEHKLAEF TNKIV
Length:185
Mass (Da):21,007
Last modified:May 1, 1999 - v1
Checksum:i91835CC2A6912C6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235272 Genomic DNA Translation: CAA15049.1
PIRiG71665
RefSeqiNP_220973.1, NC_000963.1
WP_004597952.1, NC_000963.1

Genome annotation databases

EnsemblBacteriaiCAA15049; CAA15049; CAA15049
GeneIDi883784
KEGGirpr:RP605
PATRICifig|272947.5.peg.624

Similar proteinsi

Entry informationi

Entry nameiPTH_RICPR
AccessioniPrimary (citable) accession number: Q9ZCV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: February 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health