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Q9ZCV2 (QUEE_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
7-carboxy-7-deazaguanine synthase

Short name=CDG synthase
EC=4.3.99.3
Alternative name(s):
Queuosine biosynthesis protein QueE
Gene names
Name:queE
Ordered Locus Names:RP607
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) By similarity. HAMAP-Rule MF_00917

Catalytic activity

6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH3. HAMAP-Rule MF_00917

Cofactor

Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Binds 1 S-adenosyl-L-methionine per subunit By similarity.

Pathway

Purine metabolism; 7-cyano-7-deazaguanine biosynthesis. HAMAP-Rule MF_00917

Sequence similarities

Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2342347-carboxy-7-deazaguanine synthase HAMAP-Rule MF_00917
PRO_0000416213

Sites

Metal binding551Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal binding591Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal binding621Iron-sulfur (4Fe-4S-S-AdoMet) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZCV2 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 1BC9DAEE2E04C64B

FASTA23426,247
        10         20         30         40         50         60 
MNQRINSYKM FGHNPKRSIL SGDGTKLEVQ SIFKTIQGEG IFVGYPSIFI RLGGCNLACN 

        70         80         90        100        110        120 
FCDTEFEDFK LIDIDQILNK VKNLSLNSKN AKTINLVVIT GGEPMRQPIG LLCQKLLDQD 

       130        140        150        160        170        180 
FKVQIETNGT LYRSLPKEVF IVCSPKVGKT GYNKIREDLL PQISAVKFII SKNIVEYSII 

       190        200        210        220        230 
PEVGQSAYDI PVFVQSMDQN DKRLNNENNE LAVKLALESG ARLSLQTHKF LGIE 

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235272 Genomic DNA. Translation: CAA15051.1.
PIRA71666.
RefSeqNP_220975.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZCV2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP607.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA15051; CAA15051; CAA15051.
GeneID883801.
KEGGrpr:RP607.
PATRIC17902031. VBIRicPro72556_0626.

Phylogenomic databases

HOGENOMHOG000266142.
OMAEWPQGAG.
OrthoDBEOG6RJV40.
ProtClustDBCLSK871012.

Enzyme and pathway databases

UniPathwayUPA00391.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00917. QueE.
InterProIPR024924. 7-CO-7-deazaguanine_synth-like.
IPR013785. Aldolase_TIM.
IPR007197. rSAM.
[Graphical view]
PfamPF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFPIRSF000370. QueE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQUEE_RICPR
AccessionPrimary (citable) accession number: Q9ZCV2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways