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Q9ZCV2

- QUEE_RICPR

UniProt

Q9ZCV2 - QUEE_RICPR

Protein

7-carboxy-7-deazaguanine synthase

Gene

queE

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG).UniRule annotation

    Catalytic activityi

    6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH3.UniRule annotation

    Cofactori

    Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.UniRule annotation
    Binds 1 S-adenosyl-L-methionine per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi55 – 551Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation
    Metal bindingi59 – 591Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation
    Metal bindingi62 – 621Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. carbon-nitrogen lyase activity Source: UniProtKB-HAMAP
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. queuosine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Queuosine biosynthesis

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00391.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    7-carboxy-7-deazaguanine synthaseUniRule annotation (EC:4.3.99.3UniRule annotation)
    Short name:
    CDG synthaseUniRule annotation
    Alternative name(s):
    Queuosine biosynthesis protein QueEUniRule annotation
    Gene namesi
    Name:queEUniRule annotation
    Ordered Locus Names:RP607
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2342347-carboxy-7-deazaguanine synthasePRO_0000416213Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272947.RP607.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZCV2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000266142.
    OMAiVCVSPKM.
    OrthoDBiEOG6RJV40.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00917. QueE.
    InterProiIPR024924. 7-CO-7-deazaguanine_synth-like.
    IPR013785. Aldolase_TIM.
    IPR007197. rSAM.
    [Graphical view]
    PfamiPF04055. Radical_SAM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000370. QueE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZCV2-1 [UniParc]FASTAAdd to Basket

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    MNQRINSYKM FGHNPKRSIL SGDGTKLEVQ SIFKTIQGEG IFVGYPSIFI    50
    RLGGCNLACN FCDTEFEDFK LIDIDQILNK VKNLSLNSKN AKTINLVVIT 100
    GGEPMRQPIG LLCQKLLDQD FKVQIETNGT LYRSLPKEVF IVCSPKVGKT 150
    GYNKIREDLL PQISAVKFII SKNIVEYSII PEVGQSAYDI PVFVQSMDQN 200
    DKRLNNENNE LAVKLALESG ARLSLQTHKF LGIE 234
    Length:234
    Mass (Da):26,247
    Last modified:May 1, 1999 - v1
    Checksum:i1BC9DAEE2E04C64B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235272 Genomic DNA. Translation: CAA15051.1.
    PIRiA71666.
    RefSeqiNP_220975.1. NC_000963.1.
    WP_010886333.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA15051; CAA15051; CAA15051.
    GeneIDi883801.
    KEGGirpr:RP607.
    PATRICi17902031. VBIRicPro72556_0626.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235272 Genomic DNA. Translation: CAA15051.1 .
    PIRi A71666.
    RefSeqi NP_220975.1. NC_000963.1.
    WP_010886333.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZCV2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP607.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA15051 ; CAA15051 ; CAA15051 .
    GeneIDi 883801.
    KEGGi rpr:RP607.
    PATRICi 17902031. VBIRicPro72556_0626.

    Phylogenomic databases

    HOGENOMi HOG000266142.
    OMAi VCVSPKM.
    OrthoDBi EOG6RJV40.

    Enzyme and pathway databases

    UniPathwayi UPA00391 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00917. QueE.
    InterProi IPR024924. 7-CO-7-deazaguanine_synth-like.
    IPR013785. Aldolase_TIM.
    IPR007197. rSAM.
    [Graphical view ]
    Pfami PF04055. Radical_SAM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000370. QueE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiQUEE_RICPR
    AccessioniPrimary (citable) accession number: Q9ZCV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2012
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3