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Q9ZCV2

- QUEE_RICPR

UniProt

Q9ZCV2 - QUEE_RICPR

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Protein
7-carboxy-7-deazaguanine synthase
Gene
queE, RP607
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) By similarity.UniRule annotation

Catalytic activityi

6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH3.UniRule annotation

Cofactori

Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.
Binds 1 S-adenosyl-L-methionine per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi55 – 551Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal bindingi59 – 591Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal bindingi62 – 621Iron-sulfur (4Fe-4S-S-AdoMet) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. carbon-nitrogen lyase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. queuosine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Queuosine biosynthesis

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00391.

Names & Taxonomyi

Protein namesi
Recommended name:
7-carboxy-7-deazaguanine synthase (EC:4.3.99.3)
Short name:
CDG synthase
Alternative name(s):
Queuosine biosynthesis protein QueE
Gene namesi
Name:queE
Ordered Locus Names:RP607
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2342347-carboxy-7-deazaguanine synthaseUniRule annotation
PRO_0000416213Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272947.RP607.

Structurei

3D structure databases

ProteinModelPortaliQ9ZCV2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000266142.
OMAiVCVSPKM.
OrthoDBiEOG6RJV40.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00917. QueE.
InterProiIPR024924. 7-CO-7-deazaguanine_synth-like.
IPR013785. Aldolase_TIM.
IPR007197. rSAM.
[Graphical view]
PfamiPF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF000370. QueE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZCV2-1 [UniParc]FASTAAdd to Basket

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MNQRINSYKM FGHNPKRSIL SGDGTKLEVQ SIFKTIQGEG IFVGYPSIFI    50
RLGGCNLACN FCDTEFEDFK LIDIDQILNK VKNLSLNSKN AKTINLVVIT 100
GGEPMRQPIG LLCQKLLDQD FKVQIETNGT LYRSLPKEVF IVCSPKVGKT 150
GYNKIREDLL PQISAVKFII SKNIVEYSII PEVGQSAYDI PVFVQSMDQN 200
DKRLNNENNE LAVKLALESG ARLSLQTHKF LGIE 234
Length:234
Mass (Da):26,247
Last modified:May 1, 1999 - v1
Checksum:i1BC9DAEE2E04C64B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235272 Genomic DNA. Translation: CAA15051.1.
PIRiA71666.
RefSeqiNP_220975.1. NC_000963.1.
WP_010886333.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA15051; CAA15051; CAA15051.
GeneIDi883801.
KEGGirpr:RP607.
PATRICi17902031. VBIRicPro72556_0626.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235272 Genomic DNA. Translation: CAA15051.1 .
PIRi A71666.
RefSeqi NP_220975.1. NC_000963.1.
WP_010886333.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZCV2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP607.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA15051 ; CAA15051 ; CAA15051 .
GeneIDi 883801.
KEGGi rpr:RP607.
PATRICi 17902031. VBIRicPro72556_0626.

Phylogenomic databases

HOGENOMi HOG000266142.
OMAi VCVSPKM.
OrthoDBi EOG6RJV40.

Enzyme and pathway databases

UniPathwayi UPA00391 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00917. QueE.
InterProi IPR024924. 7-CO-7-deazaguanine_synth-like.
IPR013785. Aldolase_TIM.
IPR007197. rSAM.
[Graphical view ]
Pfami PF04055. Radical_SAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF000370. QueE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiQUEE_RICPR
AccessioniPrimary (citable) accession number: Q9ZCV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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