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Q9ZCT4

- GRPE_RICPR

UniProt

Q9ZCT4 - GRPE_RICPR

Protein

Protein GrpE

Gene

grpE

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.UniRule annotation

    GO - Molecular functioni

    1. adenyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. protein folding Source: InterPro
    2. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein GrpEUniRule annotation
    Alternative name(s):
    HSP-70 cofactorUniRule annotation
    Gene namesi
    Name:grpEUniRule annotation
    Ordered Locus Names:RP629
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 178178Protein GrpEPRO_0000113849Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272947.RP629.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZCT4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GrpE family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0576.
    HOGENOMiHOG000252083.
    KOiK03687.
    OMAiKEPEFCE.
    OrthoDBiEOG6FJNJ9.

    Family and domain databases

    Gene3Di2.30.22.10. 1 hit.
    3.90.20.20. 1 hit.
    HAMAPiMF_01151. GrpE.
    InterProiIPR000740. GrpE.
    IPR013805. GrpE_coiled_coil.
    IPR009012. GrpE_head.
    [Graphical view]
    PANTHERiPTHR21237. PTHR21237. 1 hit.
    PfamiPF01025. GrpE. 1 hit.
    [Graphical view]
    PRINTSiPR00773. GRPEPROTEIN.
    SUPFAMiSSF51064. SSF51064. 1 hit.
    PROSITEiPS01071. GRPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZCT4-1 [UniParc]FASTAAdd to Basket

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    MKDYNIENNN VEEENPNVET QVVDNEEIVR LKAEIEELKD KLIRTTAEID    50
    NTRKRLEKAR DEAKDYAIAT FAKELLNVSD NLARALAHKP ANSDVEVTNI 100
    ISGVQMTKDE LDKIFHKHHI EEIKPAIGSM FDYNLHNAIS HIEHPDHEPN 150
    SIITLMQSGY KIRDRLLRPA AVQVVKKP 178
    Length:178
    Mass (Da):20,413
    Last modified:May 1, 1999 - v1
    Checksum:i669AD380DC4C6B4D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235272 Genomic DNA. Translation: CAA15070.1.
    PIRiD71668.
    RefSeqiNP_220994.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA15070; CAA15070; CAA15070.
    GeneIDi883983.
    KEGGirpr:RP629.
    PATRICi17902083. VBIRicPro72556_0651.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235272 Genomic DNA. Translation: CAA15070.1 .
    PIRi D71668.
    RefSeqi NP_220994.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZCT4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP629.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA15070 ; CAA15070 ; CAA15070 .
    GeneIDi 883983.
    KEGGi rpr:RP629.
    PATRICi 17902083. VBIRicPro72556_0651.

    Phylogenomic databases

    eggNOGi COG0576.
    HOGENOMi HOG000252083.
    KOi K03687.
    OMAi KEPEFCE.
    OrthoDBi EOG6FJNJ9.

    Family and domain databases

    Gene3Di 2.30.22.10. 1 hit.
    3.90.20.20. 1 hit.
    HAMAPi MF_01151. GrpE.
    InterProi IPR000740. GrpE.
    IPR013805. GrpE_coiled_coil.
    IPR009012. GrpE_head.
    [Graphical view ]
    PANTHERi PTHR21237. PTHR21237. 1 hit.
    Pfami PF01025. GrpE. 1 hit.
    [Graphical view ]
    PRINTSi PR00773. GRPEPROTEIN.
    SUPFAMi SSF51064. SSF51064. 1 hit.
    PROSITEi PS01071. GRPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiGRPE_RICPR
    AccessioniPrimary (citable) accession number: Q9ZCT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3