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Protein

Protein GrpE

Gene

grpE

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response

Enzyme and pathway databases

BioCyciRPRO272947:G1GT0-629-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GrpEUniRule annotation
Alternative name(s):
HSP-70 cofactorUniRule annotation
Gene namesi
Name:grpEUniRule annotation
Ordered Locus Names:RP629
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000002480 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001138491 – 178Protein GrpEAdd BLAST178

Proteomic databases

PRIDEiQ9ZCT4

Interactioni

Subunit structurei

Homodimer.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi272947.RP629

Structurei

3D structure databases

ProteinModelPortaliQ9ZCT4
SMRiQ9ZCT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105K90 Bacteria
COG0576 LUCA
HOGENOMiHOG000252083
KOiK03687
OMAiYAYEKIA

Family and domain databases

CDDicd00446 GrpE, 1 hit
Gene3Di2.30.22.10, 1 hit
3.90.20.20, 1 hit
HAMAPiMF_01151 GrpE, 1 hit
InterProiView protein in InterPro
IPR000740 GrpE
IPR013805 GrpE_coiled_coil
IPR009012 GrpE_head
PANTHERiPTHR21237 PTHR21237, 1 hit
PfamiView protein in Pfam
PF01025 GrpE, 1 hit
PRINTSiPR00773 GRPEPROTEIN
SUPFAMiSSF51064 SSF51064, 1 hit
SSF58014 SSF58014, 1 hit
PROSITEiView protein in PROSITE
PS01071 GRPE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZCT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDYNIENNN VEEENPNVET QVVDNEEIVR LKAEIEELKD KLIRTTAEID
60 70 80 90 100
NTRKRLEKAR DEAKDYAIAT FAKELLNVSD NLARALAHKP ANSDVEVTNI
110 120 130 140 150
ISGVQMTKDE LDKIFHKHHI EEIKPAIGSM FDYNLHNAIS HIEHPDHEPN
160 170
SIITLMQSGY KIRDRLLRPA AVQVVKKP
Length:178
Mass (Da):20,413
Last modified:May 1, 1999 - v1
Checksum:i669AD380DC4C6B4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235272 Genomic DNA Translation: CAA15070.1
PIRiD71668
RefSeqiNP_220994.1, NC_000963.1
WP_004596256.1, NC_000963.1

Genome annotation databases

EnsemblBacteriaiCAA15070; CAA15070; CAA15070
GeneIDi883983
KEGGirpr:RP629
PATRICifig|272947.5.peg.651

Similar proteinsi

Entry informationi

Entry nameiGRPE_RICPR
AccessioniPrimary (citable) accession number: Q9ZCT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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