Q9ZCS6 (KAD_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate kinase
Short name=AK
EC=2.7.4.3

Alternative name(s):
ATP-AMP transphosphorylase

Gene names

Name:	adk
Ordered Locus Names:	RP638

Organism

Rickettsia prowazekii (strain Madrid E)

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth By similarity. HAMAP MF_00235
Catalytic activity	ATP + AMP = 2 ADP. HAMAP MF_00235
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1. HAMAP MF_00235
Subunit structure	Monomer By similarity. HAMAP MF_00235
Subcellular location	Cytoplasm By similarity HAMAP MF_00235.
Domain	Consists of three domains, a large central CORE domain and two small peripheral domains, AMP binding and LID. The LID domain closes over the site of phosphoryl transfer upon ATP binding By similarity. HAMAP MF_00235
Sequence similarities	Belongs to the adenylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Adenylate kinase HAMAP MF_00235		PRO_0000158839
Regions
	Nucleotide binding	7 – 15	9	ATP By similarity
	Nucleotide binding	31 – 59	29	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZCS6 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 23CBD806A1BEEC19	FASTA	213	24,504
	10 20 30 40 50 60 MIVIFLGPPG AGKGTQGKKI AKKIDLPHIA VGDIFRTIIK TSTSEAELIN NYVKQGALIP 70 80 90 100 110 120 NEIVNQVIKV FLLSSKYKNG YILDGYPRNL EQAKFFEAFI QKPQIKIIYF DVADELLIKR 130 140 150 160 170 180 VLGRYSCKNC GKIYNIHFLQ PKIEHVCDVC SSSVFDYRKD DNKEVIKKRI KVYKTETYPL 190 200 210 IDYYKNSGNF YIVNANKNEQ EIENDIQKIL KIN

References

[1]	"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235272 Genomic DNA. Translation: CAA15078.1.
PIR	D71669.
RefSeq	NP_221002.1. NC_000963.1.
3D structure databases
ProteinModelPortal	Q9ZCS6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	883602.
GenomeReviews	Gene locus RP638 in contig AJ235269_GR.
KEGG	rpr:RP638.
PATRIC	17902103. VBIRicPro72556_0660.
Phylogenomic databases
HOGENOM	HBG630208.
OMA	VLGRYSC.
ProtClustDB	PRK00279.
Enzyme and pathway databases
BioCyc	RPRO272947:RP638-MONOMER.
Family and domain databases
HAMAP	MF_00235. Adenylate_kinase_Adk. [Tree]
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_lid-dom. [Graphical view]
KO	K00939.
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
SUPFAM	SSF57774. Adenylate_kinase_Znf_lid. 1 hit.
TIGRFAMs	TIGR01351. Adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD_RICPR

Accession

Primary (citable) accession number: Q9ZCS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program