Q9ZCS5 (SECY_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein translocase subunit SecY

Gene names

Name:	secY
Ordered Locus Names:	RP639

Organism

Rickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia prowazekii

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently By similarity. HAMAP-Rule MF_01465
Subunit structure	Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01465.
Sequence similarities	Belongs to the SecY/SEC61-alpha family.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular protein transmembrane transport Inferred from electronic annotation. Source: HAMAP protein targeting Inferred from electronic annotation. Source: HAMAP protein transport by the Sec complex Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 433	433	Protein translocase subunit SecY HAMAP-Rule MF_01465		PRO_0000131738
Regions
	Transmembrane	17 – 37	21	Helical; Potential
	Transmembrane	71 – 91	21	Helical; Potential
	Transmembrane	117 – 137	21	Helical; Potential
	Transmembrane	149 – 169	21	Helical; Potential
	Transmembrane	184 – 204	21	Helical; Potential
	Transmembrane	212 – 232	21	Helical; Potential
	Transmembrane	268 – 288	21	Helical; Potential
	Transmembrane	310 – 330	21	Helical; Potential
	Transmembrane	366 – 386	21	Helical; Potential
	Transmembrane	388 – 408	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZCS5 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: DE2FF632BA24A0A5	FASTA	433	47,697
	10 20 30 40 50 60 MGQNFSKKSS NDLVNRIIFT LFMLIICRFG SFIPIPGIDS IALNSVAEKN QFGILGMFNM 70 80 90 100 110 120 LSGGSLGRMS IFALAIMPYI TASIIIQLMS VAYKPLENLK KEGETGKRKI NQLSRYLTVL 130 140 150 160 170 180 LASFQAYGVA LSLESMVTNT GPVVILAGFF FRVTTVITLV VGTILLMWLG EQITQRGIGN 190 200 210 220 230 240 GTSLIIFIGI ISGVPSAIIS MFELSRKGAL SPLIAITVCI GVVLLIAIII FFEKAQRKLL 250 260 270 280 290 300 VQYPKRQVGN KIYGGEATHM PLKLNTSGVI PPIFASSILL FPTTLASFSN SNSDTMSMLT 310 320 330 340 350 360 YYLGHGKPVY ILLYVVLIMF FSFFYTAIVF NSEETANNLR KYGAYIPGKR PGKNTSDYFD 370 380 390 400 410 420 YILTRLTVIG GIYLSVICVI PELLMNKYVI SLSLGGTSFL IVVNVVLDTM TQIQTYLFSS 430 KYEGLMKKIK LKN

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235272 Genomic DNA. Translation: CAA15079.1.
PIR	E71669.
RefSeq	NP_221003.1. NC_000963.1.
3D structure databases
ProteinModelPortal	Q9ZCS5.
ModBase	Search...
Protein-protein interaction databases
STRING	272947.RP639.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAA15079; CAA15079; CAA15079.
GeneID	883612.
KEGG	rpr:RP639.
PATRIC	17902105. VBIRicPro72556_0661.
Phylogenomic databases
eggNOG	COG0201.
HOGENOM	HOG000080585.
KO	K03076.
OMA	FIMWLGE.
ProtClustDB	PRK09204.
Family and domain databases
Gene3D	1.10.3370.10. 1 hit.
HAMAP	MF_01465. SecY.
InterPro	IPR026593. SecY. IPR002208. SecY/SEC61-alpha. IPR023201. SecY_su_dom. [Graphical view]
PANTHER	PTHR10906. PTHR10906. 1 hit.
Pfam	PF00344. SecY. 1 hit. [Graphical view]
PIRSF	PIRSF004557. SecY. 1 hit.
SUPFAM	SSF103491. SecY. 1 hit.
TIGRFAMs	TIGR00967. 3a0501s007. 1 hit.
PROSITE	PS00755. SECY_1. 1 hit. PS00756. SECY_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SECY_RICPR

Accession

Primary (citable) accession number: Q9ZCS5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program