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Q9ZCS5

- SECY_RICPR

UniProt

Q9ZCS5 - SECY_RICPR

Protein

Protein translocase subunit SecY

Gene

secY

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.UniRule annotation

    GO - Biological processi

    1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
    2. protein targeting Source: UniProtKB-HAMAP
    3. protein transport by the Sec complex Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein translocase subunit SecYUniRule annotation
    Gene namesi
    Name:secYUniRule annotation
    Ordered Locus Names:RP639
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. intracellular Source: GOC
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Protein translocase subunit SecYPRO_0000131738Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.UniRule annotation

    Protein-protein interaction databases

    STRINGi272947.RP639.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZCS5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalUniRule annotationAdd
    BLAST
    Transmembranei71 – 9121HelicalUniRule annotationAdd
    BLAST
    Transmembranei117 – 13721HelicalUniRule annotationAdd
    BLAST
    Transmembranei149 – 16921HelicalUniRule annotationAdd
    BLAST
    Transmembranei184 – 20421HelicalUniRule annotationAdd
    BLAST
    Transmembranei212 – 23221HelicalUniRule annotationAdd
    BLAST
    Transmembranei268 – 28821HelicalUniRule annotationAdd
    BLAST
    Transmembranei310 – 33021HelicalUniRule annotationAdd
    BLAST
    Transmembranei366 – 38621HelicalUniRule annotationAdd
    BLAST
    Transmembranei388 – 40821HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SecY/SEC61-alpha family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0201.
    HOGENOMiHOG000080585.
    KOiK03076.
    OMAiAWNVQFY.
    OrthoDBiEOG651SWP.

    Family and domain databases

    Gene3Di1.10.3370.10. 1 hit.
    HAMAPiMF_01465. SecY.
    InterProiIPR026593. SecY.
    IPR002208. SecY/SEC61-alpha.
    IPR023201. SecY_su_dom.
    [Graphical view]
    PANTHERiPTHR10906. PTHR10906. 1 hit.
    PfamiPF00344. SecY. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004557. SecY. 1 hit.
    SUPFAMiSSF103491. SSF103491. 1 hit.
    TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
    PROSITEiPS00755. SECY_1. 1 hit.
    PS00756. SECY_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZCS5-1 [UniParc]FASTAAdd to Basket

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    MGQNFSKKSS NDLVNRIIFT LFMLIICRFG SFIPIPGIDS IALNSVAEKN    50
    QFGILGMFNM LSGGSLGRMS IFALAIMPYI TASIIIQLMS VAYKPLENLK 100
    KEGETGKRKI NQLSRYLTVL LASFQAYGVA LSLESMVTNT GPVVILAGFF 150
    FRVTTVITLV VGTILLMWLG EQITQRGIGN GTSLIIFIGI ISGVPSAIIS 200
    MFELSRKGAL SPLIAITVCI GVVLLIAIII FFEKAQRKLL VQYPKRQVGN 250
    KIYGGEATHM PLKLNTSGVI PPIFASSILL FPTTLASFSN SNSDTMSMLT 300
    YYLGHGKPVY ILLYVVLIMF FSFFYTAIVF NSEETANNLR KYGAYIPGKR 350
    PGKNTSDYFD YILTRLTVIG GIYLSVICVI PELLMNKYVI SLSLGGTSFL 400
    IVVNVVLDTM TQIQTYLFSS KYEGLMKKIK LKN 433
    Length:433
    Mass (Da):47,697
    Last modified:May 1, 1999 - v1
    Checksum:iDE2FF632BA24A0A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235272 Genomic DNA. Translation: CAA15079.1.
    PIRiE71669.
    RefSeqiNP_221003.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA15079; CAA15079; CAA15079.
    GeneIDi883612.
    KEGGirpr:RP639.
    PATRICi17902105. VBIRicPro72556_0661.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235272 Genomic DNA. Translation: CAA15079.1 .
    PIRi E71669.
    RefSeqi NP_221003.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZCS5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP639.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA15079 ; CAA15079 ; CAA15079 .
    GeneIDi 883612.
    KEGGi rpr:RP639.
    PATRICi 17902105. VBIRicPro72556_0661.

    Phylogenomic databases

    eggNOGi COG0201.
    HOGENOMi HOG000080585.
    KOi K03076.
    OMAi AWNVQFY.
    OrthoDBi EOG651SWP.

    Family and domain databases

    Gene3Di 1.10.3370.10. 1 hit.
    HAMAPi MF_01465. SecY.
    InterProi IPR026593. SecY.
    IPR002208. SecY/SEC61-alpha.
    IPR023201. SecY_su_dom.
    [Graphical view ]
    PANTHERi PTHR10906. PTHR10906. 1 hit.
    Pfami PF00344. SecY. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004557. SecY. 1 hit.
    SUPFAMi SSF103491. SSF103491. 1 hit.
    TIGRFAMsi TIGR00967. 3a0501s007. 1 hit.
    PROSITEi PS00755. SECY_1. 1 hit.
    PS00756. SECY_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiSECY_RICPR
    AccessioniPrimary (citable) accession number: Q9ZCS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3