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Q9ZCS5 (SECY_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein translocase subunit SecY
Gene names
Name:secY
Ordered Locus Names:RP639
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently By similarity. HAMAP-Rule MF_01465

Subunit structure

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01465.

Sequence similarities

Belongs to the SecY/SEC61-alpha family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Protein translocase subunit SecY HAMAP-Rule MF_01465
PRO_0000131738

Regions

Transmembrane17 – 3721Helical; Potential
Transmembrane71 – 9121Helical; Potential
Transmembrane117 – 13721Helical; Potential
Transmembrane149 – 16921Helical; Potential
Transmembrane184 – 20421Helical; Potential
Transmembrane212 – 23221Helical; Potential
Transmembrane268 – 28821Helical; Potential
Transmembrane310 – 33021Helical; Potential
Transmembrane366 – 38621Helical; Potential
Transmembrane388 – 40821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9ZCS5 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: DE2FF632BA24A0A5

FASTA43347,697
        10         20         30         40         50         60 
MGQNFSKKSS NDLVNRIIFT LFMLIICRFG SFIPIPGIDS IALNSVAEKN QFGILGMFNM 

        70         80         90        100        110        120 
LSGGSLGRMS IFALAIMPYI TASIIIQLMS VAYKPLENLK KEGETGKRKI NQLSRYLTVL 

       130        140        150        160        170        180 
LASFQAYGVA LSLESMVTNT GPVVILAGFF FRVTTVITLV VGTILLMWLG EQITQRGIGN 

       190        200        210        220        230        240 
GTSLIIFIGI ISGVPSAIIS MFELSRKGAL SPLIAITVCI GVVLLIAIII FFEKAQRKLL 

       250        260        270        280        290        300 
VQYPKRQVGN KIYGGEATHM PLKLNTSGVI PPIFASSILL FPTTLASFSN SNSDTMSMLT 

       310        320        330        340        350        360 
YYLGHGKPVY ILLYVVLIMF FSFFYTAIVF NSEETANNLR KYGAYIPGKR PGKNTSDYFD 

       370        380        390        400        410        420 
YILTRLTVIG GIYLSVICVI PELLMNKYVI SLSLGGTSFL IVVNVVLDTM TQIQTYLFSS 

       430 
KYEGLMKKIK LKN 

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235272 Genomic DNA. Translation: CAA15079.1.
PIRE71669.
RefSeqNP_221003.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZCS5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP639.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA15079; CAA15079; CAA15079.
GeneID883612.
KEGGrpr:RP639.
PATRIC17902105. VBIRicPro72556_0661.

Phylogenomic databases

eggNOGCOG0201.
HOGENOMHOG000080585.
KOK03076.
OMAAWNVQFY.
OrthoDBEOG651SWP.

Family and domain databases

Gene3D1.10.3370.10. 1 hit.
HAMAPMF_01465. SecY.
InterProIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERPTHR10906. PTHR10906. 1 hit.
PfamPF00344. SecY. 1 hit.
[Graphical view]
PIRSFPIRSF004557. SecY. 1 hit.
SUPFAMSSF103491. SSF103491. 1 hit.
TIGRFAMsTIGR00967. 3a0501s007. 1 hit.
PROSITEPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSECY_RICPR
AccessionPrimary (citable) accession number: Q9ZCS5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names