Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9ZCR0 (RL22_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
50S ribosomal protein L22
Gene names
Name:rplV
Ordered Locus Names:RP654
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length119 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome By similarity. HAMAP-Rule MF_01331

The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome By similarity. HAMAP-Rule MF_01331

Subunit structure

Part of the 50S ribosomal subunit By similarity. HAMAP-Rule MF_01331

Sequence similarities

Belongs to the ribosomal protein L22P family.

Ontologies

Keywords
   LigandRNA-binding
rRNA-binding
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentlarge ribosomal subunit

Inferred from electronic annotation. Source: InterPro

   Molecular_functionrRNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11911950S ribosomal protein L22 HAMAP-Rule MF_01331
PRO_0000125214

Sequences

Sequence LengthMass (Da)Tools
Q9ZCR0 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 3055D52DBEF5F0A2

FASTA11913,364
        10         20         30         40         50         60 
MIQKNKNFAT AKAKSIRVSP RKLNLVASFI RNMKVSEALV QLTFSPKRIA KIVKDCLQSA 

        70         80         90        100        110 
IANAENNLGL DIDRLIITKA TVGKSVVMKR IMPRAKGRAT RINKFFSNLY ITVTEKEDN 

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235272 Genomic DNA. Translation: CAA15094.1.
PIRD71671.
RefSeqNP_221018.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZCR0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP654.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA15094; CAA15094; CAA15094.
GeneID883878.
KEGGrpr:RP654.
PATRIC17902135. VBIRicPro72556_0676.

Phylogenomic databases

eggNOGCOG0091.
HOGENOMHOG000205046.
KOK02890.
OMAGRAFRIN.
OrthoDBEOG6V4GKB.
ProtClustDBPRK00565.

Family and domain databases

Gene3D3.90.470.10. 1 hit.
HAMAPMF_01331_B. Ribosomal_L22_B.
InterProIPR001063. Ribosomal_L22.
IPR018260. Ribosomal_L22/L17_CS.
IPR005727. Ribosomal_L22_bac/chlpt-type.
[Graphical view]
PANTHERPTHR13501. PTHR13501. 1 hit.
PfamPF00237. Ribosomal_L22. 1 hit.
[Graphical view]
SUPFAMSSF54843. SSF54843. 1 hit.
TIGRFAMsTIGR01044. rplV_bact. 1 hit.
PROSITEPS00464. RIBOSOMAL_L22. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRL22_RICPR
AccessionPrimary (citable) accession number: Q9ZCR0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

Ribosomal proteins

Ribosomal proteins families and list of entries