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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi107 – 1159GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. barrier septum assembly Source: UniProtKB-KW
  2. FtsZ-dependent cytokinesis Source: UniProtKB-HAMAP
  3. protein polymerization Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Septation

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:RP666
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation
Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

  1. cell division site Source: UniProtKB-HAMAP
  2. cytoplasm Source: UniProtKB-SubCell
  3. protein complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Cell division protein FtsZPRO_0000114376Add
BLAST

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi272947.RP666.

Structurei

3D structure databases

ProteinModelPortaliQ9ZCQ3.
SMRiQ9ZCQ3. Positions 16-320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0206.
HOGENOMiHOG000049094.
KOiK03531.
OMAiVESPQIY.
OrthoDBiEOG6S7XZG.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZCQ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLNIKAPEN IVLKPTITVF GVGGAGSNAV NNMIHANLQG ANFVVANTDA
60 70 80 90 100
QSLEHSLCIN KIQLGVSTTR GLGAGASPEV GALAAQESEN EIRSSLENSN
110 120 130 140 150
MVFITAGMGG GTGTGSAPII ARIAKELGIL TVGVVTKPFH FEGGHRMKTA
160 170 180 190 200
DKGLIELQQF VDTLIVIPNQ NLFRIANEQT TFADAFKMAD DVLHAGVRGV
210 220 230 240 250
TDLMIMPGLI NLDFADIKAV MSEMGKAMMG TGEDSGEDRA IKAAESAISN
260 270 280 290 300
PLLDHSSMCG ARGVLINITG GPDMTLFEVD NAANRIREEV DNIDANIIFG
310 320 330 340 350
STFNPELKGI IRVSVVATGI DADKVPKYKL AIDKNTNTLP EETYNESIIQ
360 370 380 390 400
HTQIETIPSF NSYSTENIEI NESSIKQDYT GNEQELRLHV NAVNKPENNS
410 420 430 440 450
QKSSFLGKIW ESLRTSNNQT LERKNVIVNT VDQDNKESDI HDIPAFLRKK

RD
Length:452
Mass (Da):48,806
Last modified:May 1, 1999 - v1
Checksum:iD6AC69F28B3343AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235272 Genomic DNA. Translation: CAA15104.1.
PIRiF71672.
RefSeqiNP_221028.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA15104; CAA15104; CAA15104.
GeneIDi883531.
KEGGirpr:RP666.
PATRICi17902159. VBIRicPro72556_0686.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235272 Genomic DNA. Translation: CAA15104.1.
PIRiF71672.
RefSeqiNP_221028.1. NC_000963.1.

3D structure databases

ProteinModelPortaliQ9ZCQ3.
SMRiQ9ZCQ3. Positions 16-320.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272947.RP666.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA15104; CAA15104; CAA15104.
GeneIDi883531.
KEGGirpr:RP666.
PATRICi17902159. VBIRicPro72556_0686.

Phylogenomic databases

eggNOGiCOG0206.
HOGENOMiHOG000049094.
KOiK03531.
OMAiVESPQIY.
OrthoDBiEOG6S7XZG.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiFTSZ_RICPR
AccessioniPrimary (citable) accession number: Q9ZCQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: January 7, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.