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Q9ZCQ3 (FTSZ_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division protein FtsZ
Gene names
Name:ftsZ
Ordered Locus Names:RP666
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length452 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity By similarity. HAMAP-Rule MF_00909

Subunit structure

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner By similarity. Interacts directly with several other division proteins By similarity.

Subcellular location

Cytoplasm By similarity. Note: Assembles at midcell at the inner surface of the cytoplasmic membrane By similarity. HAMAP-Rule MF_00909

Sequence similarities

Belongs to the FtsZ family.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Septation
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbarrier septum assembly

Inferred from electronic annotation. Source: UniProtKB-KW

cytokinesis by binary fission

Inferred from electronic annotation. Source: UniProtKB-HAMAP

protein polymerization

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcell division site

Inferred from electronic annotation. Source: UniProtKB-HAMAP

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

protein complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 452452Cell division protein FtsZ HAMAP-Rule MF_00909
PRO_0000114376

Regions

Nucleotide binding107 – 1159GTP Potential

Sequences

Sequence LengthMass (Da)Tools
Q9ZCQ3 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: D6AC69F28B3343AE

FASTA45248,806
        10         20         30         40         50         60 
MVLNIKAPEN IVLKPTITVF GVGGAGSNAV NNMIHANLQG ANFVVANTDA QSLEHSLCIN 

        70         80         90        100        110        120 
KIQLGVSTTR GLGAGASPEV GALAAQESEN EIRSSLENSN MVFITAGMGG GTGTGSAPII 

       130        140        150        160        170        180 
ARIAKELGIL TVGVVTKPFH FEGGHRMKTA DKGLIELQQF VDTLIVIPNQ NLFRIANEQT 

       190        200        210        220        230        240 
TFADAFKMAD DVLHAGVRGV TDLMIMPGLI NLDFADIKAV MSEMGKAMMG TGEDSGEDRA 

       250        260        270        280        290        300 
IKAAESAISN PLLDHSSMCG ARGVLINITG GPDMTLFEVD NAANRIREEV DNIDANIIFG 

       310        320        330        340        350        360 
STFNPELKGI IRVSVVATGI DADKVPKYKL AIDKNTNTLP EETYNESIIQ HTQIETIPSF 

       370        380        390        400        410        420 
NSYSTENIEI NESSIKQDYT GNEQELRLHV NAVNKPENNS QKSSFLGKIW ESLRTSNNQT 

       430        440        450 
LERKNVIVNT VDQDNKESDI HDIPAFLRKK RD 

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235272 Genomic DNA. Translation: CAA15104.1.
PIRF71672.
RefSeqNP_221028.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZCQ3.
SMRQ9ZCQ3. Positions 16-320.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP666.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA15104; CAA15104; CAA15104.
GeneID883531.
KEGGrpr:RP666.
PATRIC17902159. VBIRicPro72556_0686.

Phylogenomic databases

eggNOGCOG0206.
HOGENOMHOG000049094.
KOK03531.
OMAVESPQIY.
OrthoDBEOG6S7XZG.
ProtClustDBPRK09330.

Family and domain databases

Gene3D3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPMF_00909. FtsZ.
InterProIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSPR00423. CELLDVISFTSZ.
SMARTSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsTIGR00065. ftsZ. 1 hit.
PROSITEPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTSZ_RICPR
AccessionPrimary (citable) accession number: Q9ZCQ3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names