Q9ZCQ3 (FTSZ_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cell division protein FtsZ

Gene names

Name:	ftsZ
Ordered Locus Names:	RP666

Organism

Rickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia prowazekii

Protein attributes

Sequence length	452 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity By similarity. HAMAP-Rule MF_00909
Subunit structure	Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner By similarity. Interacts directly with several other division proteins By similarity.
Subcellular location	Cytoplasm By similarity. Note: Assembles at midcell at the inner surface of the cytoplasmic membrane By similarity.
Sequence similarities	Belongs to the FtsZ family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Septation
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	barrier septum assembly Inferred from electronic annotation. Source: UniProtKB-KW cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cytokinesis by binary fission Inferred from electronic annotation. Source: HAMAP protein polymerization Inferred from electronic annotation. Source: HAMAP
Cellular_component	cell division site part Inferred from electronic annotation. Source: HAMAP cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell protein complex Inferred from electronic annotation. Source: InterPro
Molecular_function	GTP binding Inferred from electronic annotation. Source: HAMAP GTPase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 452	452	Cell division protein FtsZ HAMAP-Rule MF_00909		PRO_0000114376
Regions
	Nucleotide binding	107 – 115	9	GTP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZCQ3 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: D6AC69F28B3343AE	FASTA	452	48,806
	10 20 30 40 50 60 MVLNIKAPEN IVLKPTITVF GVGGAGSNAV NNMIHANLQG ANFVVANTDA QSLEHSLCIN 70 80 90 100 110 120 KIQLGVSTTR GLGAGASPEV GALAAQESEN EIRSSLENSN MVFITAGMGG GTGTGSAPII 130 140 150 160 170 180 ARIAKELGIL TVGVVTKPFH FEGGHRMKTA DKGLIELQQF VDTLIVIPNQ NLFRIANEQT 190 200 210 220 230 240 TFADAFKMAD DVLHAGVRGV TDLMIMPGLI NLDFADIKAV MSEMGKAMMG TGEDSGEDRA 250 260 270 280 290 300 IKAAESAISN PLLDHSSMCG ARGVLINITG GPDMTLFEVD NAANRIREEV DNIDANIIFG 310 320 330 340 350 360 STFNPELKGI IRVSVVATGI DADKVPKYKL AIDKNTNTLP EETYNESIIQ HTQIETIPSF 370 380 390 400 410 420 NSYSTENIEI NESSIKQDYT GNEQELRLHV NAVNKPENNS QKSSFLGKIW ESLRTSNNQT 430 440 450 LERKNVIVNT VDQDNKESDI HDIPAFLRKK RD

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235272 Genomic DNA. Translation: CAA15104.1.
PIR	F71672.
RefSeq	NP_221028.1. NC_000963.1.
3D structure databases
ProteinModelPortal	Q9ZCQ3.
SMR	Q9ZCQ3. Positions 16-320.
ModBase	Search...
Protein-protein interaction databases
STRING	272947.RP666.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAA15104; CAA15104; CAA15104.
GeneID	883531.
KEGG	rpr:RP666.
PATRIC	17902159. VBIRicPro72556_0686.
Phylogenomic databases
eggNOG	COG0206.
HOGENOM	HOG000049094.
KO	K03531.
OMA	VESPQIY.
ProtClustDB	PRK09330.
Family and domain databases
Gene3D	3.30.1330.20. 1 hit. 3.40.50.1440. 1 hit.
HAMAP	MF_00909. FtsZ.
InterPro	IPR000158. Cell_div_FtsZ. IPR020805. Cell_div_FtsZ_CS. IPR024757. FtsZ_C. IPR008280. Tub_FtsZ_C. IPR018316. Tubulin/FtsZ_2-layer-sand-dom. IPR003008. Tubulin_FtsZ_GTPase. [Graphical view]
Pfam	PF12327. FtsZ_C. 1 hit. PF00091. Tubulin. 1 hit. [Graphical view]
PRINTS	PR00423. CELLDVISFTSZ.
SMART	SM00864. Tubulin. 1 hit. SM00865. Tubulin_C. 1 hit. [Graphical view]
SUPFAM	SSF55307. Tub_FtsZ_C. 1 hit. SSF52490. Tubulin_FtsZ. 1 hit.
TIGRFAMs	TIGR00065. ftsZ. 1 hit.
PROSITE	PS01134. FTSZ_1. 1 hit. PS01135. FTSZ_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTSZ_RICPR

Accession

Primary (citable) accession number: Q9ZCQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program