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Q9ZCN1 (CLPX_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-dependent Clp protease ATP-binding subunit ClpX
Gene names
Name:clpX
Ordered Locus Names:RP692
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP By similarity. HAMAP-Rule MF_00175

Subunit structure

Heterodimer of ClpP and ClpX By similarity. HAMAP-Rule MF_00175

Sequence similarities

Belongs to the ClpX chaperone family.

Ontologies

Keywords
   DomainZinc-finger
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionChaperone
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425ATP-dependent Clp protease ATP-binding subunit ClpX HAMAP-Rule MF_00175
PRO_0000160413

Regions

Zinc finger12 – 3726C4-type HAMAP-Rule MF_00175
Nucleotide binding116 – 1238ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q9ZCN1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: B92CE4748592E20E

FASTA42546,908
        10         20         30         40         50         60 
MVVDADKKEL ICSFCSKKQH EVKKLIAGPA VFICDECIDL CTDIMKEESK VALKQITASI 

        70         80         90        100        110        120 
PTPQKICKIL NDYVVGQDQA KKILAVAVYN HYKRLEYVQS GNNDVELNKS NILLIGPTGS 

       130        140        150        160        170        180 
GKTLLAQTLA KILDVPFTMA DATSLTEAGY VGEDVENILL RLLISAEFNI AKAQKGIIYI 

       190        200        210        220        230        240 
DEVDKIARKS DNPSITRDVS GEGVQQALLK IMEGTVASVP PQGGRKHPQQ DFVQLDTSNI 

       250        260        270        280        290        300 
LFICGGAFMG IDRIIRSRTN HSSIGFAANI NIDKEKSNNE ILKSLEIEDL TKFGLIPEFI 

       310        320        330        340        350        360 
GRLPIITTLD ELDKEALITI LTKPKNAIVK QYQKQFELDD ADLVIDYSAL EAIAEKALVK 

       370        380        390        400        410        420 
KTGARGLRSI LEHLLLDSMY KVAELKKQRV TITKEVVDGL IEPCMTSIIS TKLNKKQPII 


EDIPA 

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235272 Genomic DNA. Translation: CAA15129.1.
PIRG71675.
RefSeqNP_221053.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZCN1.
SMRQ9ZCN1. Positions 8-48.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP692.

Proteomic databases

PRIDEQ9ZCN1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA15129; CAA15129; CAA15129.
GeneID883549.
KEGGrpr:RP692.
PATRIC17902217. VBIRicPro72556_0714.

Phylogenomic databases

eggNOGCOG1219.
HOGENOMHOG000010093.
KOK03544.
OMALDTMFDL.
OrthoDBEOG625JZK.
ProtClustDBPRK05342.

Family and domain databases

HAMAPMF_00175. ClpX.
InterProIPR003593. AAA+_ATPase.
IPR013093. ATPase_AAA-2.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
[Graphical view]
PANTHERPTHR11262:SF4. PTHR11262:SF4. 1 hit.
PfamPF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PF06689. zf-C4_ClpX. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00382. clpX. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCLPX_RICPR
AccessionPrimary (citable) accession number: Q9ZCN1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names