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Q9ZCM9 (QUEC_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
7-cyano-7-deazaguanine synthase

EC=6.3.4.20
Alternative name(s):
7-cyano-7-carbaguanine synthase
PreQ(0) synthase
Queuosine biosynthesis protein QueC
Gene names
Name:queC
Ordered Locus Names:RP694
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ0) By similarity. HAMAP-Rule MF_01633

Catalytic activity

7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O. HAMAP-Rule MF_01633

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01633

Pathway

Purine metabolism; 7-cyano-7-deazaguanine biosynthesis. HAMAP-Rule MF_01633

Sequence similarities

Belongs to the QueC family.

Ontologies

Keywords
   Biological processQueuosine biosynthesis
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processqueuosine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

ligase activity, forming carbon-nitrogen bonds

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2272277-cyano-7-deazaguanine synthase HAMAP-Rule MF_01633
PRO_0000246914

Regions

Nucleotide binding8 – 1811ATP By similarity

Sites

Metal binding1921Zinc By similarity
Metal binding2021Zinc By similarity
Metal binding2051Zinc By similarity
Metal binding2081Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZCM9 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 7EB608D1261BE081

FASTA22725,211
        10         20         30         40         50         60 
MKKSVNLLSG GTDSATVLAI ASEMCYEIYA MSFNYGQRNN AELRKVKELI KKYNVKQHKI 

        70         80         90        100        110        120 
VDIDLRAFGG SALTDDNIDV PYYHGINALP EIVPVTYVPA RNTIFLSYAV GFAEVIGSQD 

       130        140        150        160        170        180 
IFIGVHTSDS ANYPDCCPEY IQSFEKMVNL ATNMGVQGKK ITIHAPLIDM TKEQIIRTGL 

       190        200        210        220 
KLGVDYKNTI SCYSPTEDDL SCGNCLACII RLDAFKKNNI QDPIKYV 

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235272 Genomic DNA. Translation: CAA15131.1.
PIRA71676.
RefSeqNP_221055.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZCM9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP694.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA15131; CAA15131; CAA15131.
GeneID883701.
KEGGrpr:RP694.
PATRIC17902221. VBIRicPro72556_0716.

Phylogenomic databases

eggNOGCOG0603.
HOGENOMHOG000110564.
KOK06920.
OMACLSCIAR.
OrthoDBEOG6091HB.

Enzyme and pathway databases

UniPathwayUPA00391.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_01633. QueC.
InterProIPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF06508. QueC. 1 hit.
[Graphical view]
PIRSFPIRSF006293. ExsB. 1 hit.
TIGRFAMsTIGR00364. TIGR00364. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQUEC_RICPR
AccessionPrimary (citable) accession number: Q9ZCM9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways