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Q9ZCM9

- QUEC_RICPR

UniProt

Q9ZCM9 - QUEC_RICPR

Protein

7-cyano-7-deazaguanine synthase

Gene

queC

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ0).UniRule annotation

    Catalytic activityi

    7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi192 – 1921ZincUniRule annotation
    Metal bindingi202 – 2021ZincUniRule annotation
    Metal bindingi205 – 2051ZincUniRule annotation
    Metal bindingi208 – 2081ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 1811ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. ligase activity, forming carbon-nitrogen bonds Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. queuosine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Queuosine biosynthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00391.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    7-cyano-7-deazaguanine synthaseUniRule annotation (EC:6.3.4.20UniRule annotation)
    Alternative name(s):
    7-cyano-7-carbaguanine synthaseUniRule annotation
    PreQ(0) synthaseUniRule annotation
    Queuosine biosynthesis protein QueCUniRule annotation
    Gene namesi
    Name:queCUniRule annotation
    Ordered Locus Names:RP694
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2272277-cyano-7-deazaguanine synthasePRO_0000246914Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272947.RP694.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZCM9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the QueC family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0603.
    HOGENOMiHOG000110564.
    KOiK06920.
    OMAiCLSCIAR.
    OrthoDBiEOG6091HB.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_01633. QueC.
    InterProiIPR018317. QueC.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF06508. QueC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006293. ExsB. 1 hit.
    TIGRFAMsiTIGR00364. TIGR00364. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZCM9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKSVNLLSG GTDSATVLAI ASEMCYEIYA MSFNYGQRNN AELRKVKELI    50
    KKYNVKQHKI VDIDLRAFGG SALTDDNIDV PYYHGINALP EIVPVTYVPA 100
    RNTIFLSYAV GFAEVIGSQD IFIGVHTSDS ANYPDCCPEY IQSFEKMVNL 150
    ATNMGVQGKK ITIHAPLIDM TKEQIIRTGL KLGVDYKNTI SCYSPTEDDL 200
    SCGNCLACII RLDAFKKNNI QDPIKYV 227
    Length:227
    Mass (Da):25,211
    Last modified:May 1, 1999 - v1
    Checksum:i7EB608D1261BE081
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235272 Genomic DNA. Translation: CAA15131.1.
    PIRiA71676.
    RefSeqiNP_221055.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA15131; CAA15131; CAA15131.
    GeneIDi883701.
    KEGGirpr:RP694.
    PATRICi17902221. VBIRicPro72556_0716.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235272 Genomic DNA. Translation: CAA15131.1 .
    PIRi A71676.
    RefSeqi NP_221055.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZCM9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP694.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA15131 ; CAA15131 ; CAA15131 .
    GeneIDi 883701.
    KEGGi rpr:RP694.
    PATRICi 17902221. VBIRicPro72556_0716.

    Phylogenomic databases

    eggNOGi COG0603.
    HOGENOMi HOG000110564.
    KOi K06920.
    OMAi CLSCIAR.
    OrthoDBi EOG6091HB.

    Enzyme and pathway databases

    UniPathwayi UPA00391 .

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_01633. QueC.
    InterProi IPR018317. QueC.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF06508. QueC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006293. ExsB. 1 hit.
    TIGRFAMsi TIGR00364. TIGR00364. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiQUEC_RICPR
    AccessioniPrimary (citable) accession number: Q9ZCM9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3