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Q9ZCM9

- QUEC_RICPR

UniProt

Q9ZCM9 - QUEC_RICPR

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Protein
7-cyano-7-deazaguanine synthase
Gene
queC, RP694
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ0) By similarity.UniRule annotation

Catalytic activityi

7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi192 – 1921Zinc By similarity
Metal bindingi202 – 2021Zinc By similarity
Metal bindingi205 – 2051Zinc By similarity
Metal bindingi208 – 2081Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 1811ATP By similarity
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. ligase activity, forming carbon-nitrogen bonds Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. queuosine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Queuosine biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00391.

Names & Taxonomyi

Protein namesi
Recommended name:
7-cyano-7-deazaguanine synthase (EC:6.3.4.20)
Alternative name(s):
7-cyano-7-carbaguanine synthase
PreQ(0) synthase
Queuosine biosynthesis protein QueC
Gene namesi
Name:queC
Ordered Locus Names:RP694
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2272277-cyano-7-deazaguanine synthaseUniRule annotation
PRO_0000246914Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272947.RP694.

Structurei

3D structure databases

ProteinModelPortaliQ9ZCM9.

Family & Domainsi

Sequence similaritiesi

Belongs to the QueC family.

Phylogenomic databases

eggNOGiCOG0603.
HOGENOMiHOG000110564.
KOiK06920.
OMAiCLSCIAR.
OrthoDBiEOG6091HB.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_01633. QueC.
InterProiIPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF06508. QueC. 1 hit.
[Graphical view]
PIRSFiPIRSF006293. ExsB. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZCM9-1 [UniParc]FASTAAdd to Basket

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MKKSVNLLSG GTDSATVLAI ASEMCYEIYA MSFNYGQRNN AELRKVKELI    50
KKYNVKQHKI VDIDLRAFGG SALTDDNIDV PYYHGINALP EIVPVTYVPA 100
RNTIFLSYAV GFAEVIGSQD IFIGVHTSDS ANYPDCCPEY IQSFEKMVNL 150
ATNMGVQGKK ITIHAPLIDM TKEQIIRTGL KLGVDYKNTI SCYSPTEDDL 200
SCGNCLACII RLDAFKKNNI QDPIKYV 227
Length:227
Mass (Da):25,211
Last modified:May 1, 1999 - v1
Checksum:i7EB608D1261BE081
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235272 Genomic DNA. Translation: CAA15131.1.
PIRiA71676.
RefSeqiNP_221055.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA15131; CAA15131; CAA15131.
GeneIDi883701.
KEGGirpr:RP694.
PATRICi17902221. VBIRicPro72556_0716.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235272 Genomic DNA. Translation: CAA15131.1 .
PIRi A71676.
RefSeqi NP_221055.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZCM9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP694.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA15131 ; CAA15131 ; CAA15131 .
GeneIDi 883701.
KEGGi rpr:RP694.
PATRICi 17902221. VBIRicPro72556_0716.

Phylogenomic databases

eggNOGi COG0603.
HOGENOMi HOG000110564.
KOi K06920.
OMAi CLSCIAR.
OrthoDBi EOG6091HB.

Enzyme and pathway databases

UniPathwayi UPA00391 .

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_01633. QueC.
InterProi IPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF06508. QueC. 1 hit.
[Graphical view ]
PIRSFi PIRSF006293. ExsB. 1 hit.
TIGRFAMsi TIGR00364. TIGR00364. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiQUEC_RICPR
AccessioniPrimary (citable) accession number: Q9ZCM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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