Q9ZCM8 (Y696_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative export ATP-binding/permease protein RP696
EC=3.6.3.-

Gene names

Ordered Locus Names:

RP696

Organism

Rickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia prowazekii

Protein attributes

Sequence length	576 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of an ABC transporter complex. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Domain	The ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.
Sequence similarities	Belongs to the ABC transporter superfamily. Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 576	576	Putative export ATP-binding/permease protein RP696		PRO_0000278658
Regions
	Transmembrane	21 – 41	21	Helical; Potential
	Transmembrane	61 – 81	21	Helical; Potential
	Transmembrane	135 – 155	21	Helical; Potential
	Transmembrane	158 – 178	21	Helical; Potential
	Transmembrane	242 – 262	21	Helical; Potential
	Transmembrane	277 – 297	21	Helical; Potential
	Domain	20 – 303	284	ABC transmembrane type-1
	Domain	336 – 572	237	ABC transporter
	Nucleotide binding	371 – 378	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZCM8 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: E99C360532E4073F	FASTA	576	64,928
	10 20 30 40 50 60 MDIKLLYRLA KYLRFYKKDL IIVMISLLSV SASLLLIGSI FRDLIDRGLA EDNILSVNKS 70 80 90 100 110 120 ILYICLLIVI LSVASFFRSY FINNVAEKIV NQIRKEAYSN LINYEIEEYE ELKIGDIISR 130 140 150 160 170 180 LTNDIDQIAT LIVNFLSFFI RNSVMLIGSI TLMFFESFKL ASIVIITIPI LLVPLIKFGK 190 200 210 220 230 240 HVKALSKKAL ESKSLLVSDI DETFNNIRVI YAFNHQINKI ADFDTKLQSY LIYCKTRLKI 250 260 270 280 290 300 RALFFAISIA VIFLTITLIV WIGASDIVQG DLSAGQIISF IYYAIIAGVS SGGIFELLSE 310 320 330 340 350 360 MHLPTTALER IITIIDKTSI VHNNYYALNN SDAISIEFKN VDFTYNSRPN LKVINNMSLK 370 380 390 400 410 420 INSNKFVGIV GRSGAGKSTL IQLLLRFYRQ ENGTILINNQ DISFVKPTDI RKFIAYVPQE 430 440 450 460 470 480 ASIFSDTIKS NIIFGNNKAS DYEINEIIKI TGIEEFSTKL HDGINTKIGE KGVRLSGGQK 490 500 510 520 530 540 QRIAIARALL RKPKILLLDE AMSALDTMSE QKLLNAIKKI MKGNIIISIA HRISSIESAD 550 560 570 YILVIDKGGV VTEGSHYDLS KNSEIYRNIC REQLTI

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235272 Genomic DNA. Translation: CAA15132.1.
PIR	B71676.
RefSeq	NP_221056.1. NC_000963.1.
3D structure databases
HSSP	HSSP built from PDB template 1Z2R based on UniProtKB P63359.
ProteinModelPortal	Q9ZCM8.
ModBase	Search...
Protein-protein interaction databases
STRING	272947.RP696.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAA15132; CAA15132; CAA15132.
GeneID	883987.
KEGG	rpr:RP696.
PATRIC	17902225. VBIRicPro72556_0717.
Phylogenomic databases
eggNOG	COG1132.
HOGENOM	HOG000272911.
KO	K06147.
OMA	SITLMFF.
ProtClustDB	CLSK871035.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. [Graphical view]
Pfam	PF00664. ABC_membrane. 1 hit. PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 1 hit.
PROSITE	PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y696_RICPR

Accession

Primary (citable) accession number: Q9ZCM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program