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Protein

Sec-independent protein translocase protein TatA

Gene

tatA

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.UniRule annotation

GO - Molecular functioni

  1. protein transmembrane transporter activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein secretion Source: InterPro
  2. protein transport by the Tat complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sec-independent protein translocase protein TatAUniRule annotation
Gene namesi
Name:tatAUniRule annotation
Ordered Locus Names:RP749
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB-HAMAP
  2. TAT protein transport complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5454Sec-independent protein translocase protein TatAPRO_0000097957Add
BLAST

Interactioni

Subunit structurei

The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.UniRule annotation

Protein-protein interaction databases

STRINGi272947.RP749.

Family & Domainsi

Sequence similaritiesi

Belongs to the TatA/E family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG270103.
HOGENOMiHOG000245363.
KOiK03116.
OMAiWQIFLIL.
OrthoDBiEOG64BQD5.

Family and domain databases

HAMAPiMF_00236. TatA_E.
InterProiIPR003369. TatA/B/E.
IPR006312. TatA/E.
[Graphical view]
PfamiPF02416. MttA_Hcf106. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01411. tatAE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZCJ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGMSFSHLLI VLLIIFVLFG AGKLPQVMSD LAKGLKAFKE GMKDDGNDND

KTNN
Length:54
Mass (Da):5,884
Last modified:May 1, 1999 - v1
Checksum:i607EAE2A977FA3C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235273 Genomic DNA. Translation: CAA15177.1.
PIRiA71635.
RefSeqiNP_221101.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA15177; CAA15177; CAA15177.
GeneIDi883796.
KEGGirpr:RP749.
PATRICi17902359. VBIRicPro72556_0783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235273 Genomic DNA. Translation: CAA15177.1.
PIRiA71635.
RefSeqiNP_221101.1. NC_000963.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272947.RP749.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA15177; CAA15177; CAA15177.
GeneIDi883796.
KEGGirpr:RP749.
PATRICi17902359. VBIRicPro72556_0783.

Phylogenomic databases

eggNOGiNOG270103.
HOGENOMiHOG000245363.
KOiK03116.
OMAiWQIFLIL.
OrthoDBiEOG64BQD5.

Family and domain databases

HAMAPiMF_00236. TatA_E.
InterProiIPR003369. TatA/B/E.
IPR006312. TatA/E.
[Graphical view]
PfamiPF02416. MttA_Hcf106. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01411. tatAE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiTATA_RICPR
AccessioniPrimary (citable) accession number: Q9ZCJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: January 7, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.