Reviewed, UniProtKB/Swiss-Prot Q9ZCI7 (AK_RICPR)

Names and origin

Protein names

Recommended name:
    Aspartokinase
    EC=2.7.2.4
Alternative name(s):
    Aspartate kinase

Gene names

Name:	lysC
Ordered Locus Names:	RP753

Organism

Rickettsia prowazekii [Complete proteome] [HAMAP]

Taxonomic identifier

782 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-aspartate = ADP + 4-phospho-L-aspartate.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4. Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3. Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Sequence similarities	Belongs to the aspartokinase family. Contains 1 RPE1 insert domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW aspartate kinase activity Inferred from electronic annotation. Source: EC glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 446	446	Aspartokinase		PRO_0000066680
Regions
	Domain	250 – 294	45	RPE1 insert

Sequences

	Sequence		Length	Mass (Da)
	Q9ZCI7-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 76E118506A4E3D86	FASTA	446	49,773
	10 20 30 40 50 60 MALIIQKFGG TSVANVERIK KLVPIIKAEI AKNNQVIVVV SAMAGVTNQL VTLCNEVSSL 70 80 90 100 110 120 NKRSQFAEYD VALSSGEIVT ASLLALALQE EEIKAQSLLA WQLPIRTNNN YSKALVEFIT 130 140 150 160 170 180 TDLLEKYLQL KIIPIIAGFQ GINKSNRVTT LGRGGSDTTA ALIAAAMKAD RCDIYTDVDG 190 200 210 220 230 240 IFTADPRIIP NAKRIKEIDF LEMLELASSG AKVLHPRAVE LVMRYKIDMR VLSTFSPNTE 250 260 270 280 290 300 GTLITSKDTI PLVKSTYMEE SALNTKHSTK IDIPEDASGS TYKLPIELAL QNRYNMENCV 310 320 330 340 350 360 VRCITSNKNL LKVSVNSISL SFLQVANMIT YNNNCIEFMQ EIENNIEYNF ITNLTDKNNL 370 380 390 400 410 420 QTLLTKCKNN KQIQDFTFDT EIATISLIGY GIKNDCKLLT MILSQLTQDN INVHMMQLSE 430 440 VKITLLINDK DVEKTIFNLY NLFKIS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.
[2]	"Selfish DNA in protein-coding genes of Rickettsia." Ogata H., Audic S., Barbe V., Artiguenave F., Fournier P.-E., Raoult D., Claverie J.-M. Science 290:347-350(2000) [PubMed: 11030655] [Abstract] Cited for: DOMAIN RPE1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235273 Genomic DNA. Translation: CAA15181.1.
PIR	E71635.
RefSeq	NP_221105.1.
3D structure databases
SMR	Q9ZCI7. Positions 4-443.
ModBase	Search...
Genome annotation databases
GeneID	883748.
KEGG	rpr:RP753.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG724395.
OMA	VANMITY.
Enzyme and pathway databases
BioCyc	RPRO272947:RP753-MONOMER.
BRENDA	2.7.2.4. 141977.
Family and domain databases
InterPro	IPR001048. Asp/Glu/Uridylate_kinase. IPR001341. Asp_kinase_dom. IPR018042. Aspartate_kinase_CS. IPR001057. Glu_5kinase. IPR005728. Rickett_RPE. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PRINTS	PR00474. GLU5KINASE.
TIGRFAMs	TIGR00657. asp_kinases. 1 hit. TIGR01045. RPE. 1 hit.
PROSITE	PS00324. ASPARTOKINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AK_RICPR

Accession

Primary (citable) accession number: Q9ZCI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	February 9, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)