Q9ZCG3 (NUOJ_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH-quinone oxidoreductase subunit J
EC=1.6.99.5

Alternative name(s):
NADH dehydrogenase I subunit J
NDH-1 subunit J

Gene names

Name:	nuoJ
Ordered Locus Names:	RP790

Organism

Rickettsia prowazekii (strain Madrid E)

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NADH + quinone = NAD+ + quinol.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the complex I subunit 6 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 205	205	NADH-quinone oxidoreductase subunit J		PRO_0000118379
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	26 – 46	21	Helical; Potential
	Transmembrane	54 – 74	21	Helical; Potential
	Transmembrane	89 – 109	21	Helical; Potential
	Transmembrane	142 – 162	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZCG3 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 035BD21245DB276A	FASTA	205	23,142
	10 20 30 40 50 60 MPIFFYLFTT LIIISSLCVV LSKNSVYSVL WLIFTFINGS GLMILLGAEF LAMLLIVIYV 70 80 90 100 110 120 GAVAVLFLFV IMMLDINFNQ AITKLRENLS LSIFITLIMF ADLVITIILS TKNINYSSNI 130 140 150 160 170 180 SFAIANNISN TKAIGNVLYT EFMLPFQIAG LILFVAMISC ITLTLKKRDR IKHQDIRKQL 190 200 SHNKSNVILM TKPILNKGVE NIKYE

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235273 Genomic DNA. Translation: CAA15216.1.
PIR	H71639.
RefSeq	NP_221140.1. NC_000963.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	883950.
GenomeReviews	Gene locus RP790 in contig AJ235269_GR.
KEGG	rpr:RP790.
PATRIC	17902448. VBIRicPro72556_0826.
Phylogenomic databases
HOGENOM	HBG729722.
OMA	VQNARTP.
ProtClustDB	PRK06638.
Enzyme and pathway databases
BioCyc	RPRO272947:RP790-MONOMER.
Family and domain databases
InterPro	IPR001457. NADH_UbQ/plastoQ_OxRdtase_su6. [Graphical view]
KO	K00339.
Pfam	PF00499. Oxidored_q3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUOJ_RICPR

Accession

Primary (citable) accession number: Q9ZCG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program