Q9ZCG2 (NUOK_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH-quinone oxidoreductase subunit K
EC=1.6.99.5

Alternative name(s):
NADH dehydrogenase I subunit K
NDH-1 subunit K

Gene names

Name:	nuoK
Ordered Locus Names:	RP791

Organism

Rickettsia prowazekii (strain Madrid E)

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	110 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP MF_01456
Catalytic activity	NADH + quinone = NAD+ + quinol. HAMAP MF_01456
Subunit structure	NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01456.
Sequence similarities	Belongs to the complex I subunit 4L family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP synthesis coupled electron transport Inferred from electronic annotation. Source: InterPro transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADH dehydrogenase (quinone) activity Inferred from electronic annotation. Source: EC quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 110	110	NADH-quinone oxidoreductase subunit K HAMAP MF_01456		PRO_0000118535
Regions
	Transmembrane	13 – 33	21	Helical; Potential
	Transmembrane	41 – 61	21	Helical; Potential
	Transmembrane	73 – 93	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZCG2 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: F62159A6410FA35D	FASTA	110	12,423
	10 20 30 40 50 60 MLKILNMNEY ISLNHYLILS SLVFTIGMFG LFMNRKNIIN ILMSIELMLL AVNINFVAFS 70 80 90 100 110 VYMQELSGQI FSIIILTVAA AETAIGLAIL LIYFRNKGSI KITDINKMRG

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235273 Genomic DNA. Translation: CAA15217.1.
PIR	A71640.
RefSeq	NP_221141.2. NC_000963.1.
3D structure databases
ProteinModelPortal	Q9ZCG2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	883980.
GenomeReviews	Gene locus RP791 in contig AJ235269_GR.
KEGG	rpr:RP791.
PATRIC	17902450. VBIRicPro72556_0827.
Phylogenomic databases
HOGENOM	HBG673066.
OMA	AVNINLM.
ProtClustDB	PRK05715.
Enzyme and pathway databases
BioCyc	RPRO272947:RP791-MONOMER.
Family and domain databases
HAMAP	MF_01456. NDH1_NuoK. [Tree]
InterPro	IPR001133. NADH_UbQ_OxRdtase_chain4L/K. [Graphical view]
KO	K00340.
PANTHER	PTHR11434. Oxidored_4L. 1 hit.
Pfam	PF00420. Oxidored_q2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUOK_RICPR

Accession

Primary (citable) accession number: Q9ZCG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program