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Protein

NADH-quinone oxidoreductase subunit L

Gene

nuoL

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).By similarity

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit L (EC:1.6.5.11)
Alternative name(s):
NADH dehydrogenase I subunit L
NDH-1 subunit L
Gene namesi
Name:nuoL
Ordered Locus Names:RP792
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000002480 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence analysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence analysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence analysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence analysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence analysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence analysisAdd
BLAST
Transmembranei253 – 27321HelicalSequence analysisAdd
BLAST
Transmembranei285 – 30521HelicalSequence analysisAdd
BLAST
Transmembranei313 – 33321HelicalSequence analysisAdd
BLAST
Transmembranei336 – 35621HelicalSequence analysisAdd
BLAST
Transmembranei377 – 39721HelicalSequence analysisAdd
BLAST
Transmembranei418 – 43821HelicalSequence analysisAdd
BLAST
Transmembranei465 – 48521HelicalSequence analysisAdd
BLAST
Transmembranei511 – 53121HelicalSequence analysisAdd
BLAST
Transmembranei577 – 59721HelicalSequence analysisAdd
BLAST
Transmembranei629 – 64921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 653653NADH-quinone oxidoreductase subunit LPRO_0000118223Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Protein-protein interaction databases

STRINGi272947.RP792.

Structurei

3D structure databases

ProteinModelPortaliQ9ZCG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D65. Bacteria.
COG1009. LUCA.
HOGENOMiHOG000100570.
KOiK00341.
OMAiKKIPYTF.
OrthoDBiEOG6FZ48R.

Family and domain databases

InterProiIPR003945. NADHpl_OxRdtase_5.
IPR018393. NADHpl_OxRdtase_5_subgr.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
PRINTSiPR01435. NPOXDRDTASE5.
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZCG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHQNLAIMI IILPLVSSII NGLFLNIIDK KLAKIIAISF LSLSALFSLV
60 70 80 90 100
IFCDVTLVGK IIHIKLLPWI EFKNLQVNWS IYIDQLTSIM FIAVTFVSSV
110 120 130 140 150
VHIYSLGYMA EDKGIIRFLS FLSLFTFFML MLVSADNFLQ LFCGWEGVGV
160 170 180 190 200
CSYLLIGFWH SKESANKAAI KAFITNRVSD FAFILGIITI IVYYGSANYK
210 220 230 240 250
DVFSSAKLLS NTKIFVHFSI LDIICLLLFI GCMGKSAQIG LHVWLPDAME
260 270 280 290 300
GPTPVSALIH AATMVTAGVF LVARCSYLFE YSPIVLQFIT IIGGITCLFA
310 320 330 340 350
ASIAIMQSDI KKIIAYSTCS QLGYMFMACG VSSYNSAIFH LVTHAFFKAL
360 370 380 390 400
LFLSAGNVIH AVNEHNIFKM GGLINKMPIT YGNFLIGSLA LIGIYPLSGF
410 420 430 440 450
YSKDLILEAT YSSGSFMFIF GIITAILTAI YSMKIIILVF HGKTKLEKDV
460 470 480 490 500
FKHAHEPTKI MNNPLILLVA GSFFSGMIGY YLLSMDKPNG YFHESLFNLH
510 520 530 540 550
IYKLLINHHP LYIKLLPMAV GIVGIIIGIC LYKGSLSYQT LTNESDQREK
560 570 580 590 600
DWIPKSKCKM ILVFISNVLR NKYYFDEIYN HLIIKPIHCL TYLFYFGDQK
610 620 630 640 650
IIDRFGPNGF ARVINYFCAV TCKIQTGYIF NYTLYIVSFI VVTISYFVLK

NIY
Length:653
Mass (Da):73,478
Last modified:May 1, 1999 - v1
Checksum:i540436E913D097B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235273 Genomic DNA. Translation: CAA15218.1.
PIRiB71640.
RefSeqiNP_221142.1. NC_000963.1.
WP_004596922.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA15218; CAA15218; CAA15218.
GeneIDi883813.
KEGGirpr:RP792.
PATRICi17902452. VBIRicPro72556_0828.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235273 Genomic DNA. Translation: CAA15218.1.
PIRiB71640.
RefSeqiNP_221142.1. NC_000963.1.
WP_004596922.1. NC_000963.1.

3D structure databases

ProteinModelPortaliQ9ZCG1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272947.RP792.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA15218; CAA15218; CAA15218.
GeneIDi883813.
KEGGirpr:RP792.
PATRICi17902452. VBIRicPro72556_0828.

Phylogenomic databases

eggNOGiENOG4105D65. Bacteria.
COG1009. LUCA.
HOGENOMiHOG000100570.
KOiK00341.
OMAiKKIPYTF.
OrthoDBiEOG6FZ48R.

Family and domain databases

InterProiIPR003945. NADHpl_OxRdtase_5.
IPR018393. NADHpl_OxRdtase_5_subgr.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
PRINTSiPR01435. NPOXDRDTASE5.
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiNUOL_RICPR
AccessioniPrimary (citable) accession number: Q9ZCG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 1999
Last modified: November 11, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.