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Protein

NADH-quinone oxidoreductase subunit M

Gene

nuoM

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).By similarity

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit M (EC:1.6.5.11)
Alternative name(s):
NADH dehydrogenase I subunit M
NDH-1 subunit M
Gene namesi
Name:nuoM
Ordered Locus Names:RP793
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000002480 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence analysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence analysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence analysisAdd
BLAST
Transmembranei116 – 13621HelicalSequence analysisAdd
BLAST
Transmembranei137 – 15721HelicalSequence analysisAdd
BLAST
Transmembranei170 – 19021HelicalSequence analysisAdd
BLAST
Transmembranei203 – 22321HelicalSequence analysisAdd
BLAST
Transmembranei249 – 26921HelicalSequence analysisAdd
BLAST
Transmembranei278 – 29821HelicalSequence analysisAdd
BLAST
Transmembranei315 – 33521HelicalSequence analysisAdd
BLAST
Transmembranei336 – 35621HelicalSequence analysisAdd
BLAST
Transmembranei373 – 39321HelicalSequence analysisAdd
BLAST
Transmembranei409 – 42921HelicalSequence analysisAdd
BLAST
Transmembranei456 – 47621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491NADH-quinone oxidoreductase subunit MPRO_0000118047Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Protein-protein interaction databases

STRINGi272947.RP793.

Structurei

3D structure databases

ProteinModelPortaliQ9ZCG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C8S. Bacteria.
COG1008. LUCA.
HOGENOMiHOG000100683.
KOiK00342.
OMAiEFAIYVI.
OrthoDBiEOG647TZ6.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZCG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLELPIISIT IFLPLISVLY ILLFFNQNKK ADKLSIYVAM LSSVLTFIST
60 70 80 90 100
IYILIEFDVS NNTYQFVERY TWLDKIGLEF HVGVDGIAIF FVVLTSFLTL
110 120 130 140 150
ICIIGSLFTI KKYIKEYLVC FLLMESLCIG AFTSINLLLF YLFFEAILVP
160 170 180 190 200
MYIIIGVWGG DNRIYAALKF FLYTFFGSVF FLLALIYIYS KIHSFDLTNI
210 220 230 240 250
LELIGNIPLF AQKILWWAIF IAFAIKTPMI PFHTWLPDAH VQAPTTGSVI
260 270 280 290 300
LAGILLKLGG YGFLRVLLPL FPNASQEFAI YVIYLSVIAI IYASLVALAQ
310 320 330 340 350
KDIKQMIAYS SIAHMGYVTI GIFSFTEIGI SGAIFQMLSH GIISSSLFLI
360 370 380 390 400
VGTLYERLHT KEIAKYGGVA NKMPILATFF MIAMLSSIGL PSTSGFIGEF
410 420 430 440 450
LSLLGIYKVN VVTAFIAALG IILGAVYMLK LYKEVMLGEI TNTEIKHFRD
460 470 480 490
LYKYEIISIA PLILLIIYFG LMPNSILNVF HLSVENLLIK F
Length:491
Mass (Da):55,260
Last modified:May 1, 1999 - v1
Checksum:i55C38A584CA74FF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235273 Genomic DNA. Translation: CAA15219.1.
PIRiC71640.
RefSeqiNP_221143.1. NC_000963.1.
WP_010886373.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA15219; CAA15219; CAA15219.
GeneIDi883536.
KEGGirpr:RP793.
PATRICi17902454. VBIRicPro72556_0829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235273 Genomic DNA. Translation: CAA15219.1.
PIRiC71640.
RefSeqiNP_221143.1. NC_000963.1.
WP_010886373.1. NC_000963.1.

3D structure databases

ProteinModelPortaliQ9ZCG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272947.RP793.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA15219; CAA15219; CAA15219.
GeneIDi883536.
KEGGirpr:RP793.
PATRICi17902454. VBIRicPro72556_0829.

Phylogenomic databases

eggNOGiENOG4105C8S. Bacteria.
COG1008. LUCA.
HOGENOMiHOG000100683.
KOiK00342.
OMAiEFAIYVI.
OrthoDBiEOG647TZ6.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiNUOM_RICPR
AccessioniPrimary (citable) accession number: Q9ZCG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 11, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.