Q9ZCE0 (XERC_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine recombinase XerC

Gene names

Name:	xerC
Ordered Locus Names:	RP817

Organism

Rickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia prowazekii

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids By similarity. HAMAP-Rule MF_01808
Subunit structure	Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the 'phage' integrase family. XerC subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Chromosome partition DNA integration DNA recombination
Cellular component	Cytoplasm
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW chromosome segregation Inferred from electronic annotation. Source: HAMAP transposition, DNA-mediated Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW tyrosine-based site-specific recombinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Tyrosine recombinase XerC HAMAP-Rule MF_01808		PRO_0000095323
Sites
	Active site	159	1	By similarity
	Active site	182	1	By similarity
	Active site	250	1	By similarity
	Active site	253	1	By similarity
	Active site	276	1	By similarity
	Active site	285	1	O-(3'-phospho-DNA)-tyrosine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZCE0 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 3358B17D33A37BD6	FASTA	305	35,532
	10 20 30 40 50 60 MLDISIQELI KQWQKYLILQ KNYSNNTVIA YNNDLKHFLE FMNYYNSELV TLNHIKTADI 70 80 90 100 110 120 RLIRSWLAKR KCENFTASSI ARGLSTVKNF YKFLEKTLLL NNHIIFSIKS PKKAKLLPKG 130 140 150 160 170 180 LSVDDVLISL EHIEEYGNVK WVELRNKALI VLIYAAGLRI SEALSITKLH LQNLEFIKII 190 200 210 220 230 240 GKGSKERIIP WLPLTKNLIT KYLEILPYKL DENEPIFRGR QGKKLQPSVF NRELIKLKRI 250 260 270 280 290 300 YGLPEYLTAH SFRHSFASHL LEYGADLRSI QELLGHKSLS TTQKYTQTSI KHLEAVYNTA YPIKK

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235273 Genomic DNA. Translation: CAA15242.1.
PIR	B71643.
RefSeq	NP_221166.1. NC_000963.1.
3D structure databases
ProteinModelPortal	Q9ZCE0.
ModBase	Search...
Protein-protein interaction databases
STRING	272947.RP817.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAA15242; CAA15242; CAA15242.
GeneID	883927.
KEGG	rpr:RP817.
PATRIC	17902502. VBIRicPro72556_0852.
Phylogenomic databases
eggNOG	COG0582.
HOGENOM	HOG000045294.
KO	K03733.
OMA	GNVKWVE.
ProtClustDB	PRK00236.
Family and domain databases
Gene3D	1.10.150.130. 1 hit. 1.10.443.10. 1 hit.
HAMAP	MF_01808. Recomb_XerC.
InterPro	IPR011010. DNA_brk_join_enz. IPR013762. Integrase-like_cat-core. IPR002104. Integrase_catalytic. IPR010998. Integrase_Lambda-type_N. IPR023109. Integrase_recombinase_N. IPR004107. Integrase_SAM-like_N. IPR023009. Tyrosine_recombinase_XerC/XerD. [Graphical view]
Pfam	PF02899. Phage_integr_N. 1 hit. PF00589. Phage_integrase. 1 hit. [Graphical view]
SUPFAM	SSF56349. DNA_brk_join_enz. 1 hit. SSF47823. L_intgrse_like_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

XERC_RICPR

Accession

Primary (citable) accession number: Q9ZCE0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program