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Protein

Tyrosine recombinase XerC

Gene

xerC

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei159 – 1591By similarity
Active sitei182 – 1821By similarity
Active sitei250 – 2501By similarity
Active sitei253 – 2531By similarity
Active sitei276 – 2761By similarity
Active sitei285 – 2851O-(3'-phospho-DNA)-tyrosine intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, DNA integration, DNA recombination

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine recombinase XerC
Gene namesi
Name:xerC
Ordered Locus Names:RP817
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Tyrosine recombinase XerCPRO_0000095323Add
BLAST

Interactioni

Subunit structurei

Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.By similarity

Protein-protein interaction databases

STRINGi272947.RP817.

Structurei

3D structure databases

ProteinModelPortaliQ9ZCE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0582.
HOGENOMiHOG000045294.
KOiK03733.
OMAiRNCDNFT.
OrthoDBiEOG6PZXFP.

Family and domain databases

Gene3Di1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
HAMAPiMF_01808. Recomb_XerC.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat-core.
IPR002104. Integrase_catalytic.
IPR023109. Integrase_recombinase_N.
IPR004107. Integrase_SAM-like_N.
IPR023009. Tyrosine_recombinase_XerC/XerD.
[Graphical view]
PfamiPF02899. Phage_int_SAM_1. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZCE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDISIQELI KQWQKYLILQ KNYSNNTVIA YNNDLKHFLE FMNYYNSELV
60 70 80 90 100
TLNHIKTADI RLIRSWLAKR KCENFTASSI ARGLSTVKNF YKFLEKTLLL
110 120 130 140 150
NNHIIFSIKS PKKAKLLPKG LSVDDVLISL EHIEEYGNVK WVELRNKALI
160 170 180 190 200
VLIYAAGLRI SEALSITKLH LQNLEFIKII GKGSKERIIP WLPLTKNLIT
210 220 230 240 250
KYLEILPYKL DENEPIFRGR QGKKLQPSVF NRELIKLKRI YGLPEYLTAH
260 270 280 290 300
SFRHSFASHL LEYGADLRSI QELLGHKSLS TTQKYTQTSI KHLEAVYNTA

YPIKK
Length:305
Mass (Da):35,532
Last modified:May 1, 1999 - v1
Checksum:i3358B17D33A37BD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235273 Genomic DNA. Translation: CAA15242.1.
PIRiB71643.
RefSeqiNP_221166.1. NC_000963.1.
WP_004596870.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA15242; CAA15242; CAA15242.
GeneIDi883927.
KEGGirpr:RP817.
PATRICi17902502. VBIRicPro72556_0852.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235273 Genomic DNA. Translation: CAA15242.1.
PIRiB71643.
RefSeqiNP_221166.1. NC_000963.1.
WP_004596870.1. NC_000963.1.

3D structure databases

ProteinModelPortaliQ9ZCE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272947.RP817.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA15242; CAA15242; CAA15242.
GeneIDi883927.
KEGGirpr:RP817.
PATRICi17902502. VBIRicPro72556_0852.

Phylogenomic databases

eggNOGiCOG0582.
HOGENOMiHOG000045294.
KOiK03733.
OMAiRNCDNFT.
OrthoDBiEOG6PZXFP.

Family and domain databases

Gene3Di1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
HAMAPiMF_01808. Recomb_XerC.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat-core.
IPR002104. Integrase_catalytic.
IPR023109. Integrase_recombinase_N.
IPR004107. Integrase_SAM-like_N.
IPR023009. Tyrosine_recombinase_XerC/XerD.
[Graphical view]
PfamiPF02899. Phage_int_SAM_1. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiXERC_RICPR
AccessioniPrimary (citable) accession number: Q9ZCE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: May 1, 1999
Last modified: May 27, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.