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Q9ZCE0

- XERC_RICPR

UniProt

Q9ZCE0 - XERC_RICPR

Protein

Tyrosine recombinase XerC

Gene

xerC

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei159 – 1591By similarity
    Active sitei182 – 1821By similarity
    Active sitei250 – 2501By similarity
    Active sitei253 – 2531By similarity
    Active sitei276 – 2761By similarity
    Active sitei285 – 2851O-(3'-phospho-DNA)-tyrosine intermediateBy similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. tyrosine-based site-specific recombinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. chromosome segregation Source: UniProtKB-HAMAP
    4. transposition, DNA-mediated Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Cell cycle, Cell division, Chromosome partition, DNA integration, DNA recombination

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine recombinase XerC
    Gene namesi
    Name:xerC
    Ordered Locus Names:RP817
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Tyrosine recombinase XerCPRO_0000095323Add
    BLAST

    Interactioni

    Subunit structurei

    Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.By similarity

    Protein-protein interaction databases

    STRINGi272947.RP817.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZCE0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0582.
    HOGENOMiHOG000045294.
    KOiK03733.
    OMAiQNYLKCC.
    OrthoDBiEOG6PZXFP.

    Family and domain databases

    Gene3Di1.10.150.130. 1 hit.
    1.10.443.10. 1 hit.
    HAMAPiMF_01808. Recomb_XerC.
    InterProiIPR011010. DNA_brk_join_enz.
    IPR013762. Integrase-like_cat-core.
    IPR002104. Integrase_catalytic.
    IPR023109. Integrase_recombinase_N.
    IPR004107. Integrase_SAM-like_N.
    IPR023009. Tyrosine_recombinase_XerC/XerD.
    [Graphical view]
    PfamiPF02899. Phage_int_SAM_1. 1 hit.
    PF00589. Phage_integrase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56349. SSF56349. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZCE0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLDISIQELI KQWQKYLILQ KNYSNNTVIA YNNDLKHFLE FMNYYNSELV    50
    TLNHIKTADI RLIRSWLAKR KCENFTASSI ARGLSTVKNF YKFLEKTLLL 100
    NNHIIFSIKS PKKAKLLPKG LSVDDVLISL EHIEEYGNVK WVELRNKALI 150
    VLIYAAGLRI SEALSITKLH LQNLEFIKII GKGSKERIIP WLPLTKNLIT 200
    KYLEILPYKL DENEPIFRGR QGKKLQPSVF NRELIKLKRI YGLPEYLTAH 250
    SFRHSFASHL LEYGADLRSI QELLGHKSLS TTQKYTQTSI KHLEAVYNTA 300
    YPIKK 305
    Length:305
    Mass (Da):35,532
    Last modified:May 1, 1999 - v1
    Checksum:i3358B17D33A37BD6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235273 Genomic DNA. Translation: CAA15242.1.
    PIRiB71643.
    RefSeqiNP_221166.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA15242; CAA15242; CAA15242.
    GeneIDi883927.
    KEGGirpr:RP817.
    PATRICi17902502. VBIRicPro72556_0852.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235273 Genomic DNA. Translation: CAA15242.1 .
    PIRi B71643.
    RefSeqi NP_221166.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZCE0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP817.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA15242 ; CAA15242 ; CAA15242 .
    GeneIDi 883927.
    KEGGi rpr:RP817.
    PATRICi 17902502. VBIRicPro72556_0852.

    Phylogenomic databases

    eggNOGi COG0582.
    HOGENOMi HOG000045294.
    KOi K03733.
    OMAi QNYLKCC.
    OrthoDBi EOG6PZXFP.

    Family and domain databases

    Gene3Di 1.10.150.130. 1 hit.
    1.10.443.10. 1 hit.
    HAMAPi MF_01808. Recomb_XerC.
    InterProi IPR011010. DNA_brk_join_enz.
    IPR013762. Integrase-like_cat-core.
    IPR002104. Integrase_catalytic.
    IPR023109. Integrase_recombinase_N.
    IPR004107. Integrase_SAM-like_N.
    IPR023009. Tyrosine_recombinase_XerC/XerD.
    [Graphical view ]
    Pfami PF02899. Phage_int_SAM_1. 1 hit.
    PF00589. Phage_integrase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56349. SSF56349. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiXERC_RICPR
    AccessioniPrimary (citable) accession number: Q9ZCE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 22, 2003
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3