Q9ZCD8 (PLD_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phospholipase D
Short name=PLD
EC=3.1.4.4

Alternative name(s):
Choline phosphatase

Gene names

Name:	pld
Ordered Locus Names:	RP819

Organism

Rickettsia prowazekii (strain Madrid E)

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Could be a virulence factor. Ref.2
Catalytic activity	A phosphatidylcholine + H2O = choline + a phosphatidate.
Subunit structure	Homodimer By similarity.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the phospholipase D family. Contains 1 PLD phosphodiesterase domain.

Ontologies

Keywords
Biological process	Lipid degradation Virulence
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAPE-specific phospholipase D activity Inferred from electronic annotation. Source: EC phospholipase D activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 205	183	Phospholipase D		PRO_0000274784
Regions
	Domain	142 – 169	28	PLD phosphodiesterase
Sites
	Active site	147	1	Potential
	Active site	149	1	Potential
	Active site	154	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZCD8 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: D02C9240B8A8CC5A	FASTA	205	23,078
	10 20 30 40 50 60 MKSKNNKFIA VSISFILGIA LGIYVESTYY FTNIINSKSF SLSNAQINYY SISELSRSNV 70 80 90 100 110 120 STCFTPPAGC TKFIVQQIEK AEESIYMQAY GMSDSLITTA LINAQMRGVK VRILLDRSNL 130 140 150 160 170 180 KQKFSKLYEL QQAKIDVGID TVPGIAHNKV IIIDKKKVIT GSFNFTVSAD KRNAENVILI 190 200 EDRKLAESYL QNWFSRKTTS NAVHF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.
[2]	"Identification and characterization of a phospholipase D-superfamily gene in Rickettsiae." Renesto P., Dehoux P., Gouin E., Touqui L., Cossart P., Raoult D. J. Infect. Dis. 188:1276-1283(2003) [PubMed: 14593584] [Abstract] Cited for: FUNCTION. Strain: ATCC VR-142 / Breinl.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235273 Genomic DNA. Translation: CAA15244.1.
PIR	D71643.
RefSeq	NP_221168.1. NC_000963.1.
3D structure databases
ProteinModelPortal	Q9ZCD8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	883600.
GenomeReviews	Gene locus RP819 in contig AJ235269_GR.
KEGG	rpr:RP819.
PATRIC	17902506. VBIRicPro72556_0854.
Phylogenomic databases
HOGENOM	HBG501643.
OMA	VQEYTFT.
ProtClustDB	CLSK871092.
Enzyme and pathway databases
BioCyc	RPRO272947:RP819-MONOMER.
Family and domain databases
InterPro	IPR001736. PLipase_D/transphosphatidylase. [Graphical view]
PROSITE	PS50035. PLD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PLD_RICPR

Accession

Primary (citable) accession number: Q9ZCD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program