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Q9ZCD3 (AMPM_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methionine aminopeptidase
Short name=MAP
EC=3.4.11.18
Alternative name(s):
Peptidase M
Gene names
Name:map
Ordered Locus Names:RP824
OrganismRickettsia prowazekii (strain Madrid E)
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Removes the amino-terminal methionine from nascent proteins.

Catalytic activity

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

Cofactor

Binds 2 cobalt ions per subunit. The true nature of the physiological cofactor is under debate. The enzyme is also active with zinc, manganese or divalent iron ions By similarity.

Binds 1 sodium ion per subunit. The sodium ion has a structural role By similarity.

Sequence similarities

Belongs to the peptidase M24A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 259259Methionine aminopeptidase
PRO_0000148950

Sites

Metal binding951Cobalt 1 By similarity
Metal binding1061Cobalt 1 By similarity
Metal binding1061Cobalt 2 By similarity
Metal binding1691Cobalt 2 By similarity
Metal binding2021Cobalt 2 By similarity
Metal binding2341Cobalt 1 By similarity
Metal binding2341Cobalt 2 By similarity
Binding site781Substrate By similarity
Binding site1761Substrate By similarity

Secondary structure

1 .................................. 259
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9ZCD3 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 2CBFE88F0DD67B61

FASTA25928,861
        10         20         30         40         50         60 
MTIKIHTEKD FIKMRAAGKL AAETLDFITD HVKPNVTTNS LNDLCHNFIT SHNAIPAPLN 

        70         80         90        100        110        120 
YKGFPKSICT SINHVVCHGI PNDKPLKNGD IVNIDVTVIL DGWYGDTSRM YYVGDVAIKP 

       130        140        150        160        170        180 
KRLIQVTYDA MMKGIEVVRP GAKLGDIGYA IQSYAEKHNY SVVRDYTGHG IGRVFHDKPS 

       190        200        210        220        230        240 
ILNYGRNGTG LTLKEGMFFT VEPMINAGNY DTILSKLDGW TVTTRDKSLS AQFEHTIGVT 

       250 
KDGFEIFTLS PKKLDYPPY

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed: 9823893] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ235273 Genomic DNA. Translation: CAA15249.1.
PIRA71644.
RefSeqNP_221173.1. NC_000963.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3MR1X-ray2.00A/B/C/D3-249[»]
3MX6X-ray1.70A/B3-259[»]
ProteinModelPortalQ9ZCD3.
ModBaseSearch...

Protein family/group databases

MEROPSM24.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID883940.
GenomeReviewsGene locus RP824 in contig AJ235269_GR.
KEGGrpr:RP824.
PATRIC17902518. VBIRicPro72556_0860.

Phylogenomic databases

HOGENOMHBG299384.
OMATTNSLND.
ProtClustDBPRK05716.

Enzyme and pathway databases

BioCycRPRO272947:RP824-MONOMER.

Family and domain databases

InterProIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002467. Pept_M24A_MAP1.
[Graphical view]
Gene3DG3DSA:3.90.230.10. Peptidase_M24_cat_core. 1 hit.
KOK01265.
PfamPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSPR00599. MAPEPTIDASE.
SUPFAMSSF55920. Peptidase_M24_cat_core. 1 hit.
TIGRFAMsTIGR00500. Met_pdase_I. 1 hit.
PROSITEPS00680. MAP_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAMPM_RICPR
AccessionPrimary (citable) accession number: Q9ZCD3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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