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Q9ZCB7

- TIG_RICPR

UniProt

Q9ZCB7 - TIG_RICPR

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Protein
Trigger factor
Gene
tig, RP842
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase By similarity.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. protein folding Source: UniProtKB-HAMAP
  4. protein transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Isomerase, Rotamase

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Trigger factor (EC:5.2.1.8)
Short name:
TF
Alternative name(s):
PPIase
Gene namesi
Name:tig
Ordered Locus Names:RP842
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

Cytoplasm
Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm By similarity.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Trigger factorUniRule annotation
PRO_0000179417Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272947.RP842.

Structurei

3D structure databases

ProteinModelPortaliQ9ZCB7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini162 – 24786PPIase FKBP-type
Add
BLAST

Domaini

Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own By similarity.UniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0544.
HOGENOMiHOG000218241.
KOiK03545.
OMAiMQVSVEN.
OrthoDBiEOG63VBX3.

Family and domain databases

Gene3Di1.10.3120.10. 1 hit.
3.30.70.1050. 1 hit.
HAMAPiMF_00303. Trigger_factor_Tig.
InterProiIPR001179. PPIase_FKBP_dom.
IPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamiPF00254. FKBP_C. 1 hit.
PF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
[Graphical view]
PIRSFiPIRSF003095. Trigger_factor. 1 hit.
SUPFAMiSSF102735. SSF102735. 1 hit.
SSF109998. SSF109998. 1 hit.
TIGRFAMsiTIGR00115. tig. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZCB7-1 [UniParc]FASTAAdd to Basket

« Hide

MGIIVLKNEG LNFHARISTP LSEIDDDIQK ELLDLTKKVK VAGFRAGKVP    50
VSIVKKKYGT SVRHDIIEKR INNLVNHIIK EYNLNIIGRP KIEELQNEPD 100
KDLEFTVKIE LLPKITIPDL KKISLDRPKL AVNSQDVEIQ LEKLAALTKC 150
YTKESKTKIK DGDQVTIDAI GYIKDRAFDG GKLNDFKVVI GSNTLIQGFE 200
QQLIGSKTGN EVDVNVTFPE NYHDKNLSGK DAHFVVQIKA VHTAEPTIID 250
EEFAKKFQSN SLEELRTHFA KQIENESEEA INTIMKMNLF DKLEKLLDFD 300
VPESLLEQEK NILKSETDKN KHDGSLLNGK SSKEITEYYN KLALRRVRIG 350
LLLAEYAKFK NLQLEPDDFK KIIMQQARNF PGQENMIFDF YKNNPRAIEG 400
LKGPALEDKT VQYIFNNEIQ LKEKRYTKEE LEKYLETEEQ RISLI 445
Length:445
Mass (Da):51,135
Last modified:May 1, 1999 - v1
Checksum:i86676A8A1BA56A08
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235273 Genomic DNA. Translation: CAA15266.1.
PIRiB71646.
RefSeqiNP_221190.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA15266; CAA15266; CAA15266.
GeneIDi883899.
KEGGirpr:RP842.
PATRICi17902560. VBIRicPro72556_0880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235273 Genomic DNA. Translation: CAA15266.1 .
PIRi B71646.
RefSeqi NP_221190.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZCB7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP842.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA15266 ; CAA15266 ; CAA15266 .
GeneIDi 883899.
KEGGi rpr:RP842.
PATRICi 17902560. VBIRicPro72556_0880.

Phylogenomic databases

eggNOGi COG0544.
HOGENOMi HOG000218241.
KOi K03545.
OMAi MQVSVEN.
OrthoDBi EOG63VBX3.

Family and domain databases

Gene3Di 1.10.3120.10. 1 hit.
3.30.70.1050. 1 hit.
HAMAPi MF_00303. Trigger_factor_Tig.
InterProi IPR001179. PPIase_FKBP_dom.
IPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view ]
Pfami PF00254. FKBP_C. 1 hit.
PF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF003095. Trigger_factor. 1 hit.
SUPFAMi SSF102735. SSF102735. 1 hit.
SSF109998. SSF109998. 1 hit.
TIGRFAMsi TIGR00115. tig. 1 hit.
PROSITEi PS50059. FKBP_PPIASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiTIG_RICPR
AccessioniPrimary (citable) accession number: Q9ZCB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi