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Q9ZCB7

- TIG_RICPR

UniProt

Q9ZCB7 - TIG_RICPR

Protein

Trigger factor

Gene

tig

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase By similarity.By similarity

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. protein folding Source: UniProtKB-HAMAP
    4. protein transport Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone, Isomerase, Rotamase

    Keywords - Biological processi

    Cell cycle, Cell division

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trigger factor (EC:5.2.1.8)
    Short name:
    TF
    Alternative name(s):
    PPIase
    Gene namesi
    Name:tig
    Ordered Locus Names:RP842
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    Cytoplasm
    Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Trigger factorPRO_0000179417Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272947.RP842.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZCB7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini162 – 24786PPIase FKBP-typeAdd
    BLAST

    Domaini

    Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.By similarity

    Sequence similaritiesi

    Belongs to the FKBP-type PPIase family. Tig subfamily.Curated
    Contains 1 PPIase FKBP-type domain.Curated

    Phylogenomic databases

    eggNOGiCOG0544.
    HOGENOMiHOG000218241.
    KOiK03545.
    OMAiMQVSVEN.
    OrthoDBiEOG63VBX3.

    Family and domain databases

    Gene3Di1.10.3120.10. 1 hit.
    3.30.70.1050. 1 hit.
    HAMAPiMF_00303. Trigger_factor_Tig.
    InterProiIPR001179. PPIase_FKBP_dom.
    IPR005215. Trig_fac.
    IPR008880. Trigger_fac_C.
    IPR008881. Trigger_fac_ribosome-bd_bac.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view]
    PfamiPF00254. FKBP_C. 1 hit.
    PF05698. Trigger_C. 1 hit.
    PF05697. Trigger_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003095. Trigger_factor. 1 hit.
    SUPFAMiSSF102735. SSF102735. 1 hit.
    SSF109998. SSF109998. 1 hit.
    TIGRFAMsiTIGR00115. tig. 1 hit.
    PROSITEiPS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZCB7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGIIVLKNEG LNFHARISTP LSEIDDDIQK ELLDLTKKVK VAGFRAGKVP    50
    VSIVKKKYGT SVRHDIIEKR INNLVNHIIK EYNLNIIGRP KIEELQNEPD 100
    KDLEFTVKIE LLPKITIPDL KKISLDRPKL AVNSQDVEIQ LEKLAALTKC 150
    YTKESKTKIK DGDQVTIDAI GYIKDRAFDG GKLNDFKVVI GSNTLIQGFE 200
    QQLIGSKTGN EVDVNVTFPE NYHDKNLSGK DAHFVVQIKA VHTAEPTIID 250
    EEFAKKFQSN SLEELRTHFA KQIENESEEA INTIMKMNLF DKLEKLLDFD 300
    VPESLLEQEK NILKSETDKN KHDGSLLNGK SSKEITEYYN KLALRRVRIG 350
    LLLAEYAKFK NLQLEPDDFK KIIMQQARNF PGQENMIFDF YKNNPRAIEG 400
    LKGPALEDKT VQYIFNNEIQ LKEKRYTKEE LEKYLETEEQ RISLI 445
    Length:445
    Mass (Da):51,135
    Last modified:May 1, 1999 - v1
    Checksum:i86676A8A1BA56A08
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235273 Genomic DNA. Translation: CAA15266.1.
    PIRiB71646.
    RefSeqiNP_221190.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA15266; CAA15266; CAA15266.
    GeneIDi883899.
    KEGGirpr:RP842.
    PATRICi17902560. VBIRicPro72556_0880.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235273 Genomic DNA. Translation: CAA15266.1 .
    PIRi B71646.
    RefSeqi NP_221190.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZCB7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP842.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA15266 ; CAA15266 ; CAA15266 .
    GeneIDi 883899.
    KEGGi rpr:RP842.
    PATRICi 17902560. VBIRicPro72556_0880.

    Phylogenomic databases

    eggNOGi COG0544.
    HOGENOMi HOG000218241.
    KOi K03545.
    OMAi MQVSVEN.
    OrthoDBi EOG63VBX3.

    Family and domain databases

    Gene3Di 1.10.3120.10. 1 hit.
    3.30.70.1050. 1 hit.
    HAMAPi MF_00303. Trigger_factor_Tig.
    InterProi IPR001179. PPIase_FKBP_dom.
    IPR005215. Trig_fac.
    IPR008880. Trigger_fac_C.
    IPR008881. Trigger_fac_ribosome-bd_bac.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view ]
    Pfami PF00254. FKBP_C. 1 hit.
    PF05698. Trigger_C. 1 hit.
    PF05697. Trigger_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003095. Trigger_factor. 1 hit.
    SUPFAMi SSF102735. SSF102735. 1 hit.
    SSF109998. SSF109998. 1 hit.
    TIGRFAMsi TIGR00115. tig. 1 hit.
    PROSITEi PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiTIG_RICPR
    AccessioniPrimary (citable) accession number: Q9ZCB7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3