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Protein

Glycine--tRNA ligase beta subunit

Gene

glyS

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. glycine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: InterPro
  2. glycyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine--tRNA ligase beta subunit (EC:6.1.1.14)
Alternative name(s):
Glycyl-tRNA synthetase beta subunit
Short name:
GlyRS
Gene namesi
Name:glyS
Ordered Locus Names:RP849
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 665665Glycine--tRNA ligase beta subunitPRO_0000072924Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

STRINGi272947.RP849.

Structurei

3D structure databases

ProteinModelPortaliQ9ZCB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0751.
HOGENOMiHOG000264304.
KOiK01879.
OrthoDBiEOG661H9S.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
HAMAPiMF_00255. Gly_tRNA_synth_beta.
InterProiIPR008909. DALR_anticod-bd.
IPR015944. Gly-tRNA-synth_bsu.
IPR006194. Gly-tRNA-synth_heterodimer.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamiPF05746. DALR_1. 1 hit.
PF02092. tRNA_synt_2f. 1 hit.
[Graphical view]
PRINTSiPR01045. TRNASYNTHGB.
SMARTiSM00836. DALR_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00211. glyS. 1 hit.
PROSITEiPS50861. AA_TRNA_LIGASE_II_GLYAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZCB1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSELLLELF SEEIPAFMQK NAEEGYLKIF TKIFEENEIF AKVQVFAGPR
60 70 80 90 100
RITLHATHVP KVILPKEEEI KGPSIEAPEI AINGFCKAHN VSKLDLSTKL
110 120 130 140 150
RNNKLYYFFV KKTKERETKE ILPKIIIDAI NKYSWTKSMF WGCYKIKWIR
160 170 180 190 200
PLRNILCIFD GEILPLRFGH LSTNNITYGH RLTNNKKLEI IDFENYRNKL
210 220 230 240 250
LENNVILERL KREEIIKVGL LELANAQNLN IKQDVCLIEE VTGLSEFPIV
260 270 280 290 300
LLGKIPQKFL ELPEEVIVSV MRTHQKYFCL FDKNGSFAPY FLFVINGRFV
310 320 330 340 350
NTELIIQGNE KVLSARLADA LYFYKNDIAK TLESRLDKLK SVIFHTKLGS
360 370 380 390 400
LKEKVDRITD ICRYIAPDNI DLIMAAKLCK SDLVSDMVGE FPDLQGIMGY
410 420 430 440 450
YYAKHEELNE EVAKAIRDHY KPQGLNDNVP SGNATLLALA DKLDSLVGLI
460 470 480 490 500
IVGETPNGSG DPYALRRQAL GIIRIIIENK LEINFINLIS FSVSLYKVSS
510 520 530 540 550
NSHLDSVISF FEERAKFYFK NDYDITLINA VLDLNLVDTK FKLDTLKEFL
560 570 580 590 600
VQDVGKQLLN AYKRVSNIMG NQKITGLVDA SLFSTQYEKE LFEVIQKISQ
610 620 630 640 650
QIIVIIANKD YQKALNLLSS LLKPITSFFD NVLVNDSDPK IAQNRLSLLQ
660
NTCEVFDKVA KFCRL
Length:665
Mass (Da):76,216
Last modified:December 1, 2000 - v2
Checksum:iA193D931CE7463F5
GO

Sequence cautioni

The sequence CAA15273.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235273 Genomic DNA. Translation: CAA15273.1. Different initiation.
PIRiA71647.
RefSeqiNP_221197.2. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA15273; CAA15273; CAA15273.
GeneIDi883343.
KEGGirpr:RP849.
PATRICi17902574. VBIRicPro72556_0887.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235273 Genomic DNA. Translation: CAA15273.1. Different initiation.
PIRiA71647.
RefSeqiNP_221197.2. NC_000963.1.

3D structure databases

ProteinModelPortaliQ9ZCB1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272947.RP849.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA15273; CAA15273; CAA15273.
GeneIDi883343.
KEGGirpr:RP849.
PATRICi17902574. VBIRicPro72556_0887.

Phylogenomic databases

eggNOGiCOG0751.
HOGENOMiHOG000264304.
KOiK01879.
OrthoDBiEOG661H9S.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
HAMAPiMF_00255. Gly_tRNA_synth_beta.
InterProiIPR008909. DALR_anticod-bd.
IPR015944. Gly-tRNA-synth_bsu.
IPR006194. Gly-tRNA-synth_heterodimer.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamiPF05746. DALR_1. 1 hit.
PF02092. tRNA_synt_2f. 1 hit.
[Graphical view]
PRINTSiPR01045. TRNASYNTHGB.
SMARTiSM00836. DALR_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00211. glyS. 1 hit.
PROSITEiPS50861. AA_TRNA_LIGASE_II_GLYAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiSYGB_RICPR
AccessioniPrimary (citable) accession number: Q9ZCB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: February 4, 2015
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.