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Q9ZCA3

- TRUA_RICPR

UniProt

Q9ZCA3 - TRUA_RICPR

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Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521NucleophileUniRule annotation
Binding sitei111 – 1111SubstrateUniRule annotation

GO - Molecular functioni

  1. pseudouridine synthase activity Source: UniProtKB-HAMAP
  2. RNA binding Source: InterPro

GO - Biological processi

  1. tRNA pseudouridine synthesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthaseUniRule annotation
tRNA pseudouridylate synthase IUniRule annotation
tRNA-uridine isomerase IUniRule annotation
Gene namesi
Name:truAUniRule annotation
Ordered Locus Names:RP857
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245tRNA pseudouridine synthase APRO_0000057441Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272947.RP857.

Structurei

3D structure databases

ProteinModelPortaliQ9ZCA3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0101.
HOGENOMiHOG000248672.
KOiK06173.
OrthoDBiEOG6Z9B4R.

Family and domain databases

Gene3Di3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPiMF_00171. TruA.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERiPTHR11142. PTHR11142. 1 hit.
PfamiPF01416. PseudoU_synth_1. 2 hits.
[Graphical view]
PIRSFiPIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00071. hisT_truA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZCA3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYRYKITIEY LGTHFAGWQR QAGVLSVQQI LEEAIYKFSS EQVTLFGSGR
60 70 80 90 100
TDAGVHAIGQ VAHFDLSKYL EPYKIIKAIN YFVRPYDVGV WNCELVSNNF
110 120 130 140 150
HARFSAISRH YIYRIINRTY PSVIDFNRAW WISSPLDILA MQKAAAYLLG
160 170 180 190 200
KHDFTSFRSS SCQSKSPIKT LTEINIIKEY EEIKLYISAP SFLHYMVRNI
210 220 230 240
VGSLVLVGKN IWQAEQIKNV LDARDRKIAG PTAPAFGLYF IKAEY
Length:245
Mass (Da):28,170
Last modified:October 19, 2002 - v2
Checksum:i9062DA2C8539BF46
GO

Sequence cautioni

The sequence CAA15281.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235273 Genomic DNA. Translation: CAA15281.1. Different initiation.
PIRiA71648.
RefSeqiNP_221205.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA15281; CAA15281; CAA15281.
GeneIDi883320.
KEGGirpr:RP857.
PATRICi17902592. VBIRicPro72556_0896.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235273 Genomic DNA. Translation: CAA15281.1 . Different initiation.
PIRi A71648.
RefSeqi NP_221205.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZCA3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP857.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA15281 ; CAA15281 ; CAA15281 .
GeneIDi 883320.
KEGGi rpr:RP857.
PATRICi 17902592. VBIRicPro72556_0896.

Phylogenomic databases

eggNOGi COG0101.
HOGENOMi HOG000248672.
KOi K06173.
OrthoDBi EOG6Z9B4R.

Family and domain databases

Gene3Di 3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPi MF_00171. TruA.
InterProi IPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view ]
PANTHERi PTHR11142. PTHR11142. 1 hit.
Pfami PF01416. PseudoU_synth_1. 2 hits.
[Graphical view ]
PIRSFi PIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMi SSF55120. SSF55120. 1 hit.
TIGRFAMsi TIGR00071. hisT_truA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiTRUA_RICPR
AccessioniPrimary (citable) accession number: Q9ZCA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 19, 2002
Last modified: October 1, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3