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Q9ZC86

- HEM6_RICPR

UniProt

Q9ZC86 - HEM6_RICPR

Protein

Oxygen-dependent coproporphyrinogen-III oxidase

Gene

hemF

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.UniRule annotation

    Catalytic activityi

    Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O.UniRule annotation

    Cofactori

    Divalent cations.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei102 – 1021SubstrateUniRule annotation
    Metal bindingi106 – 1061Divalent cationUniRule annotation
    Active sitei116 – 1161Proton donorUniRule annotation
    Metal bindingi116 – 1161Divalent cationUniRule annotation
    Metal bindingi149 – 1491Divalent cationUniRule annotation
    Metal bindingi179 – 1791Divalent cationUniRule annotation
    Sitei179 – 1791Important for dimerizationUniRule annotation

    GO - Molecular functioni

    1. coproporphyrinogen oxidase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW
    3. protein homodimerization activity Source: UniProtKB

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Heme biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00322.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent coproporphyrinogen-III oxidaseUniRule annotation (EC:1.3.3.3UniRule annotation)
    Short name:
    CPOUniRule annotation
    Short name:
    Coprogen oxidaseUniRule annotation
    Short name:
    CoproporphyrinogenaseUniRule annotation
    Gene namesi
    Name:hemFUniRule annotation
    Ordered Locus Names:RP882
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 279279Oxygen-dependent coproporphyrinogen-III oxidasePRO_0000109916Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272947.RP882.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZC86.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni118 – 1203Substrate bindingUniRule annotation
    Regioni244 – 27936Important for dimerizationUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the aerobic coproporphyrinogen-III oxidase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0408.
    HOGENOMiHOG000262768.
    KOiK00228.
    OMAiEVYPRYK.
    OrthoDBiEOG67T5GJ.

    Family and domain databases

    Gene3Di3.40.1500.10. 1 hit.
    HAMAPiMF_00333. Coprogen_oxidas.
    InterProiIPR001260. Coprogen_oxidase_aer.
    IPR018375. Coprogen_oxidase_CS.
    [Graphical view]
    PANTHERiPTHR10755. PTHR10755. 1 hit.
    PfamiPF01218. Coprogen_oxidas. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000166. Coproporphyri_ox. 1 hit.
    PRINTSiPR00073. COPRGNOXDASE.
    SUPFAMiSSF102886. SSF102886. 1 hit.
    PROSITEiPS01021. COPROGEN_OXIDASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZC86-1 [UniParc]FASTAAdd to Basket

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    MNTENKEITS NWFTNLRDLL CKEFEKIEEK YAQIKGLKPA KFVRTSWKRN    50
    GGGCGIMSLM KGEVFEKVGV NISTVFGEFS QEFRSEILGA ELDGKFFATG 100
    ISVVAHLKSP LIPAMHFNTR YIETSKNWFG GGGDLTPFYP EENETAKFHT 150
    AFKEACDKYD SSYYPKFKKQ CDEYFYLRHR KEPRGVGGIF YDYLNSGNFE 200
    QDFAFTKDIG KALLSVYPEI VRSKLFLPWT AEQKEYQLIR RGRYVEFNLL 250
    YDRGTKFGLM TDGNVEAILM SLPPVVKFN 279
    Length:279
    Mass (Da):32,197
    Last modified:May 1, 1999 - v1
    Checksum:i334D2FFDA55220AF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235273 Genomic DNA. Translation: CAA15304.1.
    PIRiH71650.
    RefSeqiNP_221228.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA15304; CAA15304; CAA15304.
    GeneIDi883468.
    KEGGirpr:RP882.
    PATRICi17902646. VBIRicPro72556_0922.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235273 Genomic DNA. Translation: CAA15304.1 .
    PIRi H71650.
    RefSeqi NP_221228.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZC86.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP882.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA15304 ; CAA15304 ; CAA15304 .
    GeneIDi 883468.
    KEGGi rpr:RP882.
    PATRICi 17902646. VBIRicPro72556_0922.

    Phylogenomic databases

    eggNOGi COG0408.
    HOGENOMi HOG000262768.
    KOi K00228.
    OMAi EVYPRYK.
    OrthoDBi EOG67T5GJ.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00322 .

    Family and domain databases

    Gene3Di 3.40.1500.10. 1 hit.
    HAMAPi MF_00333. Coprogen_oxidas.
    InterProi IPR001260. Coprogen_oxidase_aer.
    IPR018375. Coprogen_oxidase_CS.
    [Graphical view ]
    PANTHERi PTHR10755. PTHR10755. 1 hit.
    Pfami PF01218. Coprogen_oxidas. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000166. Coproporphyri_ox. 1 hit.
    PRINTSi PR00073. COPRGNOXDASE.
    SUPFAMi SSF102886. SSF102886. 1 hit.
    PROSITEi PS01021. COPROGEN_OXIDASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiHEM6_RICPR
    AccessioniPrimary (citable) accession number: Q9ZC86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3