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Q9ZC86

- HEM6_RICPR

UniProt

Q9ZC86 - HEM6_RICPR

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Protein

Oxygen-dependent coproporphyrinogen-III oxidase

Gene

hemF

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.UniRule annotation

Catalytic activityi

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei102 – 1021SubstrateUniRule annotation
Metal bindingi106 – 1061Divalent cationUniRule annotation
Active sitei116 – 1161Proton donorUniRule annotation
Metal bindingi116 – 1161Divalent cationUniRule annotation
Metal bindingi149 – 1491Divalent cationUniRule annotation
Metal bindingi179 – 1791Divalent cationUniRule annotation
Sitei179 – 1791Important for dimerizationUniRule annotation

GO - Molecular functioni

  1. coproporphyrinogen oxidase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. protein homodimerization activity Source: UniProtKB

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00251; UER00322.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent coproporphyrinogen-III oxidaseUniRule annotation (EC:1.3.3.3UniRule annotation)
Short name:
CPOUniRule annotation
Short name:
Coprogen oxidaseUniRule annotation
Short name:
CoproporphyrinogenaseUniRule annotation
Gene namesi
Name:hemFUniRule annotation
Ordered Locus Names:RP882
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Oxygen-dependent coproporphyrinogen-III oxidasePRO_0000109916Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272947.RP882.

Structurei

3D structure databases

ProteinModelPortaliQ9ZC86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni118 – 1203Substrate bindingUniRule annotation
Regioni244 – 27936Important for dimerizationUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the aerobic coproporphyrinogen-III oxidase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0408.
HOGENOMiHOG000262768.
KOiK00228.
OMAiEVYPRYK.
OrthoDBiEOG67T5GJ.

Family and domain databases

Gene3Di3.40.1500.10. 1 hit.
HAMAPiMF_00333. Coprogen_oxidas.
InterProiIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
PANTHERiPTHR10755. PTHR10755. 1 hit.
PfamiPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFiPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSiPR00073. COPRGNOXDASE.
SUPFAMiSSF102886. SSF102886. 1 hit.
PROSITEiPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZC86-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTENKEITS NWFTNLRDLL CKEFEKIEEK YAQIKGLKPA KFVRTSWKRN
60 70 80 90 100
GGGCGIMSLM KGEVFEKVGV NISTVFGEFS QEFRSEILGA ELDGKFFATG
110 120 130 140 150
ISVVAHLKSP LIPAMHFNTR YIETSKNWFG GGGDLTPFYP EENETAKFHT
160 170 180 190 200
AFKEACDKYD SSYYPKFKKQ CDEYFYLRHR KEPRGVGGIF YDYLNSGNFE
210 220 230 240 250
QDFAFTKDIG KALLSVYPEI VRSKLFLPWT AEQKEYQLIR RGRYVEFNLL
260 270
YDRGTKFGLM TDGNVEAILM SLPPVVKFN
Length:279
Mass (Da):32,197
Last modified:May 1, 1999 - v1
Checksum:i334D2FFDA55220AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235273 Genomic DNA. Translation: CAA15304.1.
PIRiH71650.
RefSeqiNP_221228.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA15304; CAA15304; CAA15304.
GeneIDi883468.
KEGGirpr:RP882.
PATRICi17902646. VBIRicPro72556_0922.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235273 Genomic DNA. Translation: CAA15304.1 .
PIRi H71650.
RefSeqi NP_221228.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZC86.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP882.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA15304 ; CAA15304 ; CAA15304 .
GeneIDi 883468.
KEGGi rpr:RP882.
PATRICi 17902646. VBIRicPro72556_0922.

Phylogenomic databases

eggNOGi COG0408.
HOGENOMi HOG000262768.
KOi K00228.
OMAi EVYPRYK.
OrthoDBi EOG67T5GJ.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00322 .

Family and domain databases

Gene3Di 3.40.1500.10. 1 hit.
HAMAPi MF_00333. Coprogen_oxidas.
InterProi IPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view ]
PANTHERi PTHR10755. PTHR10755. 1 hit.
Pfami PF01218. Coprogen_oxidas. 1 hit.
[Graphical view ]
PIRSFi PIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSi PR00073. COPRGNOXDASE.
SUPFAMi SSF102886. SSF102886. 1 hit.
PROSITEi PS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiHEM6_RICPR
AccessioniPrimary (citable) accession number: Q9ZC86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: November 26, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3