Q9ZC68 (ASTD_YERPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-succinylglutamate 5-semialdehyde dehydrogenase
EC=1.2.1.71

Alternative name(s):
Succinylglutamic semialdehyde dehydrogenase
Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	YPO1964, y2347, YP_1709

Organism

Yersinia pestis

Taxonomic identifier

632 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 505	505	N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174		PRO_0000262436
Regions
	Nucleotide binding	234 – 239	6	NAD By similarity
Sites
	Active site	257	1	By similarity
	Active site	291	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZC68 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 989EEAA284781632	FASTA	505	54,765
	10 20 30 40 50 60 MSQHVMFNAV LSSHPALFIQ GEWRIGNGVS FEKQDPMSQQ RLWQARAADH TDVTLACHAA 70 80 90 100 110 120 RAAFPAWARA SLEQRATVIQ QFAALLEQHK QSLARTISLE TSKPYWETLT EVQAMIGKVA 130 140 150 160 170 180 ISLQAYQTRT GHSQTPMGDS MSVLRHRPHG VLAVFGPYNF PGHLPNGHIV PALLAGNTVV 190 200 210 220 230 240 FKPSELTPWT AEETVKLWQQ AGIPDGVLNL VQGGRETGEA LAAQPDIDGL LFTGSAHTGY 250 260 270 280 290 300 HLHRQLAGQP EKMLALEMGG NNALIVEQVK DRDAVVNLAI QSAFISAGQR CTCSRRLLVK 310 320 330 340 350 360 TGAEGDAFLL RFTAVAQALR IGRWDEQPAP FMGAVISSQA AERMLAAQQH LLLLGGESLL 370 380 390 400 410 420 NMTRPDSQSA LLTPGIIDIT NISEVPDEEY FGPLVSVIRY TDFTEALKIA NQTRFGLAVG 430 440 450 460 470 480 LVSEDRQQFE QLLLEARAGI VNWNKPLTGA SSAAPFGGVG ASGNHRPSAF YAADYCAWPM 490 500 ASLECEHLTL PATLSPGISF DLPKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence of the 102 kbases unstable region of Yersinia pestis." Buchrieser C., Rusniok C., Couve E., Frangeul L., Billault A., Kunst F., Carniel E., Glaser P. Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 6/69.
[2]	"Genome sequence of Yersinia pestis, the causative agent of plague." Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:523-527(2001) [PubMed: 11586360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CO-92 / Biovar Orientalis.
[3]	"Genome sequence of Yersinia pestis KIM." Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. , Matson J.S., Blattner F.R., Perry R.D. J. Bacteriol. 184:4601-4611(2002) [PubMed: 12142430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KIM5 / Biovar Mediaevalis.
[4]	"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans." Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R. DNA Res. 11:179-197(2004) [PubMed: 15368893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL031866 Genomic DNA. Translation: CAA21339.1. AL590842 Genomic DNA. Translation: CAL20602.1. AE009952 Genomic DNA. Translation: AAM85905.1. AE017042 Genomic DNA. Translation: AAS61938.1.
PIR	AG0239. T46996.
RefSeq	NP_669654.1. NC_004088.1. NP_993061.1. NC_005810.1. YP_002346953.1. NC_003143.1.
3D structure databases
ProteinModelPortal	Q9ZC68.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9ZC68. 12 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1147294. 1174803. 2763274.
GenomeReviews	Gene locus y2347 in contig AE009952_GR. Gene locus YP_1709 in contig AE017042_GR. Gene locus YPO1964 in contig AL590842_GR.
KEGG	ype:YPO1964. ypk:y2347. ypm:YP_1709.
Phylogenomic databases
HOGENOM	HBG752218.
OMA	MTQRDPR.
ProtClustDB	PRK09457.
Enzyme and pathway databases
BioCyc	YPES187410:Y2347-MONOMER.
Family and domain databases
HAMAP	MF_01174. Aldedh_AstD. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KO	K06447.
PANTHER	PTHR11699:SF24. PTHR11699:SF24. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR03240. Arg_catab_astD. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_YERPE

Accession

Primary (citable) accession number: Q9ZC68
Secondary accession number(s): Q74UK4, Q7CI72

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	May 1, 1999
Last modified:	November 16, 2011
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program