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Q9ZC49 (GLSA2_YERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutaminase 2

EC=3.5.1.2
Gene names
Name:glsA2
Ordered Locus Names:YPO1939, y2372, YP_1682
OrganismYersinia pestis [Reference proteome] [HAMAP]
Taxonomic identifier632 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamine + H2O = L-glutamate + NH3. HAMAP-Rule MF_00313

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00313

Sequence similarities

Belongs to the glutaminase family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutamine metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutaminase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340Glutaminase 2 HAMAP-Rule MF_00313
PRO_0000110634

Sites

Binding site891Substrate By similarity
Binding site1401Substrate By similarity
Binding site1911Substrate By similarity
Binding site2151Substrate By similarity
Binding site2671Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZC49 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 95A0CE7C739E6D85

FASTA34036,180
        10         20         30         40         50         60 
MEITDMPTDD SNNGIIDYVS TGHLPDPETV VKLVQEAHKR FSTDTAGVVS NVYPALERIP 

        70         80         90        100        110        120 
ADLFGICMVG TNGKIHSAGD VDYEFTIMSV SKPFVFALVC QAIGAKTARE KLGVNSTGMA 

       130        140        150        160        170        180 
FNSVTAIERA SDGRTNPMVN SGAIATTSLV PGATSDEQWK FIYDGLCRFA GRELTLNEEV 

       190        200        210        220        230        240 
YQSACETNFR NRGIANVLQG YGRLGCDPII ATDLYTRQCS LNVSARDLAV MGATLADGGV 

       250        260        270        280        290        300 
NPLTRERVVD NDICHYALAV MVTAGLYETS GDWLYDIGLP GKSGIGGGIV TVSPGKGGLG 

       310        320        330        340 
TFAPLLDSAG NSIKGQLAAR FLSRSLGMDM FVSEPYTEKN 

« Hide

References

« Hide 'large scale' references
[1]"DNA sequence of the 102 kbases unstable region of Yersinia pestis."
Buchrieser C., Rusniok C., Couve E., Frangeul L., Billault A., Kunst F., Carniel E., Glaser P.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 6/69.
[2]"Genome sequence of Yersinia pestis, the causative agent of plague."
Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. expand/collapse author list , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.
Nature 413:523-527(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CO-92 / Biovar Orientalis.
[3]"Genome sequence of Yersinia pestis KIM."
Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. expand/collapse author list , Matson J.S., Blattner F.R., Perry R.D.
J. Bacteriol. 184:4601-4611(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KIM10+ / Biovar Mediaevalis.
[4]"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. expand/collapse author list , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL031866 Genomic DNA. Translation: CAA21362.1.
AL590842 Genomic DNA. Translation: CAL20577.1.
AE009952 Genomic DNA. Translation: AAM85930.1.
AE017042 Genomic DNA. Translation: AAS61912.1.
PIRAF0236.
T47019.
RefSeqNP_669679.1. NC_004088.1.
NP_993035.1. NC_005810.1.
YP_002346928.1. NC_003143.1.

3D structure databases

ProteinModelPortalQ9ZC49.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9ZC49. 1 interaction.
STRING214092.YPO1939.

Protocols and materials databases

DNASU1147319.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM85930; AAM85930; y2372.
AAS61912; AAS61912; YP_1682.
GeneID1147319.
1174778.
2767250.
KEGGype:YPO1939.
ypk:y2372.
ypm:YP_1682.

Phylogenomic databases

eggNOGCOG2066.
HOGENOMHOG000216890.
KOK01425.
OMAAKALMLT.
OrthoDBEOG6N94BK.
ProtClustDBPRK12356.

Enzyme and pathway databases

BioCycYPES214092:GKDD-1916-MONOMER.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
HAMAPMF_00313. Glutaminase.
InterProIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERPTHR12544. PTHR12544. 1 hit.
PfamPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMSSF56601. SSF56601. 1 hit.
TIGRFAMsTIGR03814. Gln_ase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGLSA2_YERPE
AccessionPrimary (citable) accession number: Q9ZC49
Secondary accession number(s): Q0WFL0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families