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Protein

Glutaminase 2

Gene

glsA2

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei89 – 891SubstrateUniRule annotation
Binding sitei140 – 1401SubstrateUniRule annotation
Binding sitei191 – 1911SubstrateUniRule annotation
Binding sitei215 – 2151SubstrateUniRule annotation
Binding sitei267 – 2671SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciYPES214092:GKDD-1916-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase 2UniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsA2UniRule annotation
Ordered Locus Names:YPO1939, y2372, YP_1682
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815 Componenti: Chromosome UP000001019 Componenti: Chromosome UP000002490 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Glutaminase 2PRO_0000110634Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

IntActiQ9ZC49. 1 interaction.
STRINGi187410.y2372.

Structurei

3D structure databases

ProteinModelPortaliQ9ZC49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiVCHYALA.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZC49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEITDMPTDD SNNGIIDYVS TGHLPDPETV VKLVQEAHKR FSTDTAGVVS
60 70 80 90 100
NVYPALERIP ADLFGICMVG TNGKIHSAGD VDYEFTIMSV SKPFVFALVC
110 120 130 140 150
QAIGAKTARE KLGVNSTGMA FNSVTAIERA SDGRTNPMVN SGAIATTSLV
160 170 180 190 200
PGATSDEQWK FIYDGLCRFA GRELTLNEEV YQSACETNFR NRGIANVLQG
210 220 230 240 250
YGRLGCDPII ATDLYTRQCS LNVSARDLAV MGATLADGGV NPLTRERVVD
260 270 280 290 300
NDICHYALAV MVTAGLYETS GDWLYDIGLP GKSGIGGGIV TVSPGKGGLG
310 320 330 340
TFAPLLDSAG NSIKGQLAAR FLSRSLGMDM FVSEPYTEKN
Length:340
Mass (Da):36,180
Last modified:May 1, 1999 - v1
Checksum:i95A0CE7C739E6D85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031866 Genomic DNA. Translation: CAA21362.1.
AL590842 Genomic DNA. Translation: CAL20577.1.
AE009952 Genomic DNA. Translation: AAM85930.1.
AE017042 Genomic DNA. Translation: AAS61912.1.
PIRiAF0236.
T47019.
RefSeqiYP_002346928.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM85930; AAM85930; y2372.
AAS61912; AAS61912; YP_1682.
GeneIDi1174778.
KEGGiype:YPO1939.
ypk:y2372.
ypm:YP_1682.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031866 Genomic DNA. Translation: CAA21362.1.
AL590842 Genomic DNA. Translation: CAL20577.1.
AE009952 Genomic DNA. Translation: AAM85930.1.
AE017042 Genomic DNA. Translation: AAS61912.1.
PIRiAF0236.
T47019.
RefSeqiYP_002346928.1. NC_003143.1.

3D structure databases

ProteinModelPortaliQ9ZC49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9ZC49. 1 interaction.
STRINGi187410.y2372.

Protocols and materials databases

DNASUi1147319.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM85930; AAM85930; y2372.
AAS61912; AAS61912; YP_1682.
GeneIDi1174778.
KEGGiype:YPO1939.
ypk:y2372.
ypm:YP_1682.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiVCHYALA.
OrthoDBiEOG6N94BK.

Enzyme and pathway databases

BioCyciYPES214092:GKDD-1916-MONOMER.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence of the 102 kbases unstable region of Yersinia pestis."
    Buchrieser C., Rusniok C., Couve E., Frangeul L., Billault A., Kunst F., Carniel E., Glaser P.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 6/69.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  4. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiGLSA2_YERPE
AccessioniPrimary (citable) accession number: Q9ZC49
Secondary accession number(s): Q0WFL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 1999
Last modified: July 22, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.