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Q9ZC49

- GLSA2_YERPE

UniProt

Q9ZC49 - GLSA2_YERPE

Protein

Glutaminase 2

Gene

glsA2

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei89 – 891SubstrateUniRule annotation
    Binding sitei140 – 1401SubstrateUniRule annotation
    Binding sitei191 – 1911SubstrateUniRule annotation
    Binding sitei215 – 2151SubstrateUniRule annotation
    Binding sitei267 – 2671SubstrateUniRule annotation

    GO - Molecular functioni

    1. glutaminase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciYPES214092:GKDD-1916-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutaminase 2UniRule annotation (EC:3.5.1.2UniRule annotation)
    Gene namesi
    Name:glsA2UniRule annotation
    Ordered Locus Names:YPO1939, y2372, YP_1682
    OrganismiYersinia pestis
    Taxonomic identifieri632 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340Glutaminase 2PRO_0000110634Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    IntActiQ9ZC49. 1 interaction.
    STRINGi214092.YPO1939.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZC49.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutaminase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2066.
    HOGENOMiHOG000216890.
    KOiK01425.
    OMAiSANYIPA.
    OrthoDBiEOG6N94BK.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    HAMAPiMF_00313. Glutaminase.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view]
    PANTHERiPTHR12544. PTHR12544. 1 hit.
    PfamiPF04960. Glutaminase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZC49-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEITDMPTDD SNNGIIDYVS TGHLPDPETV VKLVQEAHKR FSTDTAGVVS    50
    NVYPALERIP ADLFGICMVG TNGKIHSAGD VDYEFTIMSV SKPFVFALVC 100
    QAIGAKTARE KLGVNSTGMA FNSVTAIERA SDGRTNPMVN SGAIATTSLV 150
    PGATSDEQWK FIYDGLCRFA GRELTLNEEV YQSACETNFR NRGIANVLQG 200
    YGRLGCDPII ATDLYTRQCS LNVSARDLAV MGATLADGGV NPLTRERVVD 250
    NDICHYALAV MVTAGLYETS GDWLYDIGLP GKSGIGGGIV TVSPGKGGLG 300
    TFAPLLDSAG NSIKGQLAAR FLSRSLGMDM FVSEPYTEKN 340
    Length:340
    Mass (Da):36,180
    Last modified:May 1, 1999 - v1
    Checksum:i95A0CE7C739E6D85
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL031866 Genomic DNA. Translation: CAA21362.1.
    AL590842 Genomic DNA. Translation: CAL20577.1.
    AE009952 Genomic DNA. Translation: AAM85930.1.
    AE017042 Genomic DNA. Translation: AAS61912.1.
    PIRiAF0236.
    T47019.
    RefSeqiNP_669679.1. NC_004088.1.
    NP_993035.1. NC_005810.1.
    YP_002346928.1. NC_003143.1.

    Genome annotation databases

    EnsemblBacteriaiAAM85930; AAM85930; y2372.
    AAS61912; AAS61912; YP_1682.
    GeneIDi1147319.
    1174778.
    2767250.
    KEGGiype:YPO1939.
    ypk:y2372.
    ypm:YP_1682.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL031866 Genomic DNA. Translation: CAA21362.1 .
    AL590842 Genomic DNA. Translation: CAL20577.1 .
    AE009952 Genomic DNA. Translation: AAM85930.1 .
    AE017042 Genomic DNA. Translation: AAS61912.1 .
    PIRi AF0236.
    T47019.
    RefSeqi NP_669679.1. NC_004088.1.
    NP_993035.1. NC_005810.1.
    YP_002346928.1. NC_003143.1.

    3D structure databases

    ProteinModelPortali Q9ZC49.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9ZC49. 1 interaction.
    STRINGi 214092.YPO1939.

    Protocols and materials databases

    DNASUi 1147319.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM85930 ; AAM85930 ; y2372 .
    AAS61912 ; AAS61912 ; YP_1682 .
    GeneIDi 1147319.
    1174778.
    2767250.
    KEGGi ype:YPO1939.
    ypk:y2372.
    ypm:YP_1682.

    Phylogenomic databases

    eggNOGi COG2066.
    HOGENOMi HOG000216890.
    KOi K01425.
    OMAi SANYIPA.
    OrthoDBi EOG6N94BK.

    Enzyme and pathway databases

    BioCyci YPES214092:GKDD-1916-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    HAMAPi MF_00313. Glutaminase.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view ]
    PANTHERi PTHR12544. PTHR12544. 1 hit.
    Pfami PF04960. Glutaminase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence of the 102 kbases unstable region of Yersinia pestis."
      Buchrieser C., Rusniok C., Couve E., Frangeul L., Billault A., Kunst F., Carniel E., Glaser P.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 6/69.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CO-92 / Biovar Orientalis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIM10+ / Biovar Mediaevalis.
    4. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
      Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
      , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
      DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91001 / Biovar Mediaevalis.

    Entry informationi

    Entry nameiGLSA2_YERPE
    AccessioniPrimary (citable) accession number: Q9ZC49
    Secondary accession number(s): Q0WFL0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3