ID   Q9ZBW1_STRCO            Unreviewed;       648 AA.
AC   Q9ZBW1;
DT   01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT   01-MAY-1999, sequence version 1.
DT   27-MAR-2024, entry version 131.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   OrderedLocusNames=SCO6557 {ECO:0000313|EMBL:CAA22361.1};
GN   ORFNames=SC4B5.07c {ECO:0000313|EMBL:CAA22361.1};
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226 {ECO:0000313|EMBL:CAA22361.1, ECO:0000313|Proteomes:UP000001973};
RN   [1] {ECO:0000313|EMBL:CAA22361.1, ECO:0000313|Proteomes:UP000001973}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145
RC   {ECO:0000313|Proteomes:UP000001973};
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA   Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
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DR   EMBL; AL939128; CAA22361.1; -; Genomic_DNA.
DR   PIR; T34999; T34999.
DR   RefSeq; NP_630638.1; NC_003888.3.
DR   RefSeq; WP_011031005.1; NZ_VNID01000002.1.
DR   AlphaFoldDB; Q9ZBW1; -.
DR   STRING; 100226.gene:17764214; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   PaxDb; 100226-SCO6557; -.
DR   PATRIC; fig|100226.15.peg.6661; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_430157_0_0_11; -.
DR   InParanoid; Q9ZBW1; -.
DR   OrthoDB; 7294637at2; -.
DR   PhylomeDB; Q9ZBW1; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IBA:GO_Central.
DR   GO; GO:0006689; P:ganglioside catabolic process; IBA:GO_Central.
DR   GO; GO:0009313; P:oligosaccharide catabolic process; IBA:GO_Central.
DR   CDD; cd00110; LamG; 1.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR006558; LamG-like.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF13385; Laminin_G_3; 1.
DR   SMART; SM00282; LamG; 1.
DR   SMART; SM00560; LamGL; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001973};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..648
FT                   /note="exo-alpha-sialidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5030177081"
FT   DOMAIN          470..610
FT                   /note="LamG-like jellyroll fold"
FT                   /evidence="ECO:0000259|SMART:SM00560"
FT   DOMAIN          470..605
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|SMART:SM00282"
SQ   SEQUENCE   648 AA;  68216 MW;  F1CD5835276679EB CRC64;
     MPPRTRRPFW LALATSCALA VSSPFPAHAR PGDRAPAFGE QVLFDAARDP GGYACFRIPA
     IVRTTDGTLL AFAEGRVLDC ADDGDIDIVL RRSLDGGRTW GPLRVVNDGG GDTHGNPAPV
     VDRATGRVLL LETYNAGRTD SADCAVPCAR VPHVQHSDDG GRTWSAPRDL SPEILPPDWN
     SWYATGPVHG VQLTGGAHPG RLVVGVNAET WDGERSEMGV PPAGGWGRVT ANHAALVVSD
     DGGEHWRTGA TDTWPVAADG TFRQKPSELT LTERADGALL VSGREENGTD PGHRTQALSR
     DGGDSFAAPF RALPDLYAPQ VQGAVLRLGN RILLSAPADP DRRRTMTVRS SRDGGATWDS
     ADRGTVVTRD WAGYSDLVTV DDDTVGLLYE GGKTDARDEI RFARLTADRL APPRGPDPTT
     PDLAANAAPA AVLGGAAPTT DGAVGGALAF DGADDAVRLP YDGRLALGEG DFTASLWFRY
     SAADGEQPLL WMGGIGTTQP QVWLRAEPDA GRVQGLITAR DGATAPRSAW VRTDRAYDDG
     RWHRLTLRRG GGRLTLFVDG SAAADAADVP GSVSRNSPFG VHIGERMDGR ARFTGAVDDV
     QVWNSALTDT EIAAGVPPAA GRSTVLHLPL DRVDEAAADT GGSTDTGG
//