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Protein

Multifunctional fusion protein

Gene

secF

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, TranslocationUniRule annotationSAAS annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Multifunctional fusion proteinUniRule annotation
Including the following 2 domains:
Protein translocase subunit SecDUniRule annotation
Protein-export membrane protein SecFUniRule annotation
Gene namesi
Name:secFUniRule annotation
Synonyms:secDUniRule annotation
Ordered Locus Names:SCO6160Imported
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)Imported
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei296 – 316HelicalUniRule annotationAdd BLAST21
Transmembranei323 – 343HelicalUniRule annotationAdd BLAST21
Transmembranei349 – 368HelicalUniRule annotationAdd BLAST20
Transmembranei389 – 415HelicalUniRule annotationAdd BLAST27
Transmembranei427 – 450HelicalUniRule annotationAdd BLAST24
Transmembranei488 – 508HelicalUniRule annotationAdd BLAST21
Transmembranei601 – 618HelicalUniRule annotationAdd BLAST18
Transmembranei623 – 646HelicalUniRule annotationAdd BLAST24
Transmembranei652 – 673HelicalUniRule annotationAdd BLAST22
Transmembranei704 – 722HelicalUniRule annotationAdd BLAST19
Transmembranei728 – 752HelicalUniRule annotationAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 12Sequence analysisAdd BLAST12
ChainiPRO_500433884413 – 795Multifunctional fusion proteinSequence analysisAdd BLAST783

Interactioni

Subunit structurei

Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation
Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO6160.

Structurei

3D structure databases

ProteinModelPortaliQ9ZBS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecD/SecF family. SecD subfamily.UniRule annotation
Belongs to the SecD/SecF family. SecF subfamily.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107RSV. Bacteria.
COG0341. LUCA.
COG0342. LUCA.
HOGENOMiHOG000018636.
InParanoidiQ9ZBS8.
KOiK12257.
OMAiPNNQLVI.
OrthoDBiPOG091H02C5.
PhylomeDBiQ9ZBS8.

Family and domain databases

HAMAPiMF_01463_B. SecD_B. 1 hit.
MF_01464_B. SecF_B. 1 hit.
InterProiView protein in InterPro
IPR005791. SecD.
IPR022813. SecD/SecF_arch_bac.
IPR022645. SecD/SecF_bac.
IPR022646. SecD/SecF_CS.
IPR005665. SecF_bac.
PfamiView protein in Pfam
PF07549. Sec_GG. 2 hits.
PF02355. SecD_SecF. 2 hits.
PRINTSiPR01755. SECFTRNLCASE.
TIGRFAMsiTIGR00916. 2A0604s01. 1 hit.
TIGR00966. 3a0501s07. 1 hit.
TIGR01129. secD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZBS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRSRPPSRS RSRTRSRSLN VRALVALAVM AGAVAIALTM PVRLGLDLRG
60 70 80 90 100
GTQIVLETKS TETTKADREA TDRTVEVLRG RIDALGVAEP TIVRSGENRV
110 120 130 140 150
VVELPGVQDP KKAADVLGRT AQLTVHSVLG AAEKPADATE GRTETAEDGE
160 170 180 190 200
RVLPDESGQS LRLKAATLTG QDVKGADARF DQQNGAGWTV TVDFKDSGSD
210 220 230 240 250
RWAQVTGEAA CNPAGDPTRR VAIVLDDKII SSPQVDPSVS CGAGITGGST
260 270 280 290 300
QITGSFDDAE ARELALLIKG GALPVPVETI EQRTIGATLG DEAIDAGAWA
310 320 330 340 350
AVIGTALTAL FIIVVYRLMG ALATVALLCY GLISYAALAA VGATLTLPGL
360 370 380 390 400
AGFVLAIGMA VDANVLVFER AREEQAARTR PSTRSALTAG FRSAFSAIAD
410 420 430 440 450
SNITTLIAAA LLFFLASGPV KGFGVTLGIG VLASMVSALV ITRVLAEFAA
460 470 480 490 500
SRPAVFRRPR ITGISSTGPV RDALLRRDPF LMRRPRRWLA ASLIVLVVAG
510 520 530 540 550
SGILVRGLNF GIEFTGGRLI EYSTATQVDP DRARDALADA GFPRAVVQSS
560 570 580 590 600
GDGDLTVRTE ELTDTEAATV TKAVAELGGE TEKVRDELIG PSLGEELRRD
610 620 630 640 650
ALIALGLALA AQLAYLAVRF RLLFGTAAVG ALAHDVVILV GVFAWLGKPI
660 670 680 690 700
DGVFLAALLT VIGYSVNDSV VLFDRIRELL GKERKAPFDR LTNDAILQTL
710 720 730 740 750
PRTVNTGMGA VLILASLAIL ADDSLTDFAL ALLIGVGVGT YSSVFTASPL
760 770 780 790
AIELHNRDTG SRPGRRRGGR TRATGKSEKP GKQVPTSRTE RQEVR
Length:795
Mass (Da):83,542
Last modified:May 1, 1999 - v1
Checksum:i38403390078C5BF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939126 Genomic DNA. Translation: CAA22394.1.
PIRiT34673.
RefSeqiNP_630265.1. NC_003888.3.
WP_011030698.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAA22394; CAA22394; CAA22394.
GeneIDi1101601.
KEGGisco:SCO6160.
PATRICifig|100226.15.peg.6268.

Similar proteinsi

Entry informationi

Entry nameiQ9ZBS8_STRCO
AccessioniPrimary (citable) accession number: Q9ZBS8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: September 27, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported