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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:SCO5557.1
ORF Names:SCO5557a
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003987161 – 2122-phospho-L-lactate guanylyltransferaseAdd BLAST212

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO5557a

Structurei

3D structure databases

ProteinModelPortaliQ9ZBS2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105ME0 Bacteria
COG1920 LUCA
HOGENOMiHOG000223639
InParanoidiQ9ZBS2
KOiK14941
OMAiAMLVDTI
OrthoDBiPOG091H0B3J

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZBS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQWTLVVPVK ALARAKSRLS DTADDGLRPG LALAFAQDTV AAALACPAVA
60 70 80 90 100
DVAVVTDDAR AGRELAALGA GVVADEPGGG LNAALAHGAA VVRAARPESP
110 120 130 140 150
VAALNADLPA LRPAELARVL AAATQFPRAF LPDAAGIGTT LLTVAPGQEL
160 170 180 190 200
APAFGADSRA RHRASGAVEL RLDAVDSVRQ DVDTGGDLRS ALALGVGPRT
210
AAVAARLLIA GQ
Length:212
Mass (Da):21,151
Last modified:May 1, 1999 - v1
Checksum:iC5DD4E60407C9735
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939124 Genomic DNA Translation: CAA22400.1
PIRiT35641
RefSeqiNP_629692.1, NC_003888.3
WP_003973437.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAA22400; CAA22400; CAA22400
GeneIDi1100998
KEGGisco:SCO5557a
PATRICifig|100226.15.peg.5646

Similar proteinsi

Entry informationi

Entry nameiCOFC_STRCO
AccessioniPrimary (citable) accession number: Q9ZBS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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