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Q9ZBR9 (DDL_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Synonyms:ddlA
Ordered Locus Names:SCO5560
ORF Names:SC7A1.04
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 389389D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000177885

Regions

Domain169 – 379211ATP-grasp
Nucleotide binding205 – 26056ATP By similarity

Sites

Metal binding3331Magnesium or manganese 1 By similarity
Metal binding3461Magnesium or manganese 1 By similarity
Metal binding3461Magnesium or manganese 2 By similarity
Metal binding3481Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZBR9 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 9F25CE27B761DF49

FASTA38942,273
        10         20         30         40         50         60 
MSTENLPQNP EQSPRRPPRK PRVAVVFGGR SSEHGISVVT AGAVLAAIDR TRYDVLPIGI 

        70         80         90        100        110        120 
TRDGRWALTA DEPERMAITE RRTPDVEELA ESTEGGVLLP VDPANREVVY SEPGSVPKAL 

       130        140        150        160        170        180 
GEVDVVFPVL HGPYGEDGTL QGLLELSGVP YVGAGVLASA VGQDKEYMKA VFTSYGLKVG 

       190        200        210        220        230        240 
PYAVIRPREW EQDRSGARKK IVDFAGEHGW PLFVKPARAG SSIGITKVDD LAGLDEAIEE 

       250        260        270        280        290        300 
ARRHDPKILV EAALRGREIE CGVLEFEDGP RASVPAEIPP PSEHAYYDFE AKYIDSTPGI 

       310        320        330        340        350        360 
VPAPLTAEET AEVQRLAVAA FDAASCEGLV RADFFLTEDD EFVINEINTM PGFTPISMYP 

       370        380 
QMWQASGVSY PELVDRLVQA ALRRPTGLR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL939124 Genomic DNA. Translation: CAA22403.1.
PIRT35644.
RefSeqNP_629695.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ9ZBR9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO5560.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA22403; CAA22403; CAA22403.
GeneID1101001.
KEGGsco:SCO5560.
PATRIC23740996. VBIStrCoe124346_5649.

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAQIDVIFP.
OrthoDBEOG64BQ73.
PhylomeDBQ9ZBR9.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_STRCO
AccessionPrimary (citable) accession number: Q9ZBR9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways