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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.By similarity

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi333Magnesium or manganese 1By similarity1
Metal bindingi346Magnesium or manganese 1By similarity1
Metal bindingi346Magnesium or manganese 2By similarity1
Metal bindingi348Magnesium or manganese 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi205 – 260ATPBy similarityAdd BLAST56

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligase (EC:6.3.2.4)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddl
Synonyms:ddlA
Ordered Locus Names:SCO5560
ORF Names:SC7A1.04
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001778851 – 389D-alanine--D-alanine ligaseAdd BLAST389

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO5560

Structurei

3D structure databases

ProteinModelPortaliQ9ZBR9
SMRiQ9ZBR9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 379ATP-graspAdd BLAST211

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.Curated

Phylogenomic databases

eggNOGiENOG4105CPF Bacteria
COG1181 LUCA
HOGENOMiHOG000011593
InParanoidiQ9ZBR9
KOiK01921
OMAiYETKYTE
OrthoDBiPOG091H06GK
PhylomeDBiQ9ZBR9

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PIRSFiPIRSF039102 Ddl/VanB, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
PS00844 DALA_DALA_LIGASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZBR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTENLPQNP EQSPRRPPRK PRVAVVFGGR SSEHGISVVT AGAVLAAIDR
60 70 80 90 100
TRYDVLPIGI TRDGRWALTA DEPERMAITE RRTPDVEELA ESTEGGVLLP
110 120 130 140 150
VDPANREVVY SEPGSVPKAL GEVDVVFPVL HGPYGEDGTL QGLLELSGVP
160 170 180 190 200
YVGAGVLASA VGQDKEYMKA VFTSYGLKVG PYAVIRPREW EQDRSGARKK
210 220 230 240 250
IVDFAGEHGW PLFVKPARAG SSIGITKVDD LAGLDEAIEE ARRHDPKILV
260 270 280 290 300
EAALRGREIE CGVLEFEDGP RASVPAEIPP PSEHAYYDFE AKYIDSTPGI
310 320 330 340 350
VPAPLTAEET AEVQRLAVAA FDAASCEGLV RADFFLTEDD EFVINEINTM
360 370 380
PGFTPISMYP QMWQASGVSY PELVDRLVQA ALRRPTGLR
Length:389
Mass (Da):42,273
Last modified:May 1, 1999 - v1
Checksum:i9F25CE27B761DF49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939124 Genomic DNA Translation: CAA22403.1
PIRiT35644
RefSeqiNP_629695.1, NC_003888.3
WP_003973434.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAA22403; CAA22403; CAA22403
GeneIDi1101001
KEGGisco:SCO5560
PATRICifig|100226.15.peg.5649

Similar proteinsi

Entry informationi

Entry nameiDDL_STRCO
AccessioniPrimary (citable) accession number: Q9ZBR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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