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Q9ZBR6 (THID_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

EC=2.7.1.49
EC=2.7.4.7
Alternative name(s):
Hydroxymethylpyrimidine kinase
Short name=HMP kinase
Hydroxymethylpyrimidine phosphate kinase
Short name=HMP-P kinase
Short name=HMP-phosphate kinase
Short name=HMPP kinase
Gene names
Name:thiD
Ordered Locus Names:SCO5563
ORF Names:SC7A1.07
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P By similarity.

Catalytic activity

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.

ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 2/3.

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.

Sequence similarities

Belongs to the ThiD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
PRO_0000192035

Sites

Binding site511Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZBR6 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: FE8A63759214230A

FASTA26927,277
        10         20         30         40         50         60 
MTAPTPPVTP PLVLTVAGSD SGGGAGIQAD LKTMLALGTH GMSVLTAVTA QNSRGVQGAW 

        70         80         90        100        110        120 
ELPVEAVRAQ YRSVVDDIGV QAVKTGMLSS AELVETVAEL LAGTDAPAVV DPVGVSKHGD 

       130        140        150        160        170        180 
ALLASSALES VRTRLLPVAT VATPNLDEVA QLTGVRVDDE TDLRRAAAAV LAFGPRWALI 

       190        200        210        220        230        240 
KGGHLAGDAV DLLTDGSEEH WLRAPRLDNR HTHGTGCTLA SAVACGLAKG QSVPVAVRAA 

       250        260 
KEYVTGAITA GFPLGGGIGP VDHGWALGE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL939124 Genomic DNA. Translation: CAA22406.1.
PIRT35647.
RefSeqNP_629698.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ9ZBR6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO5563.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA22406; CAA22406; CAA22406.
GeneID1101004.
KEGGsco:SCO5563.
PATRIC23741002. VBIStrCoe124346_5652.

Phylogenomic databases

eggNOGCOG0351.
HOGENOMHOG000225275.
KOK00941.
OMAFAFHCVH.
OrthoDBEOG6XWV53.
PhylomeDBQ9ZBR6.
ProtClustDBCLSK902947.

Enzyme and pathway databases

UniPathwayUPA00060; UER00137.
UPA00060; UER00138.

Family and domain databases

InterProIPR013749. HMP-P_kinase-1.
IPR004399. HMP-P_kinase-2.
[Graphical view]
PfamPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
TIGRFAMsTIGR00097. HMP-P_kinase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHID_STRCO
AccessionPrimary (citable) accession number: Q9ZBR6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways