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Q9ZBR6

- THID_STRCO

UniProt

Q9ZBR6 - THID_STRCO

Protein

Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene

thiD

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.By similarity

    Catalytic activityi

    ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.
    ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei51 – 511SubstrateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hydroxymethylpyrimidine kinase activity Source: UniProtKB-EC
    3. phosphomethylpyrimidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00060; UER00137.
    UPA00060; UER00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (EC:2.7.1.49, EC:2.7.4.7)
    Alternative name(s):
    Hydroxymethylpyrimidine kinase
    Short name:
    HMP kinase
    Hydroxymethylpyrimidine phosphate kinase
    Short name:
    HMP-P kinase
    Short name:
    HMP-phosphate kinase
    Short name:
    HMPP kinase
    Gene namesi
    Name:thiD
    Ordered Locus Names:SCO5563
    ORF Names:SC7A1.07
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Hydroxymethylpyrimidine/phosphomethylpyrimidine kinasePRO_0000192035Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi100226.SCO5563.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZBR6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ThiD family.Curated

    Phylogenomic databases

    eggNOGiCOG0351.
    HOGENOMiHOG000225275.
    KOiK00941.
    OMAiTNHWAYS.
    OrthoDBiEOG6XWV53.
    PhylomeDBiQ9ZBR6.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    InterProiIPR004399. HMP/HMP-P_kinase.
    IPR013749. PM/HMP-P_kinase-1.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF08543. Phos_pyr_kin. 1 hit.
    [Graphical view]
    SUPFAMiSSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00097. HMP-P_kinase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZBR6-1 [UniParc]FASTAAdd to Basket

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    MTAPTPPVTP PLVLTVAGSD SGGGAGIQAD LKTMLALGTH GMSVLTAVTA    50
    QNSRGVQGAW ELPVEAVRAQ YRSVVDDIGV QAVKTGMLSS AELVETVAEL 100
    LAGTDAPAVV DPVGVSKHGD ALLASSALES VRTRLLPVAT VATPNLDEVA 150
    QLTGVRVDDE TDLRRAAAAV LAFGPRWALI KGGHLAGDAV DLLTDGSEEH 200
    WLRAPRLDNR HTHGTGCTLA SAVACGLAKG QSVPVAVRAA KEYVTGAITA 250
    GFPLGGGIGP VDHGWALGE 269
    Length:269
    Mass (Da):27,277
    Last modified:May 1, 1999 - v1
    Checksum:iFE8A63759214230A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939124 Genomic DNA. Translation: CAA22406.1.
    PIRiT35647.
    RefSeqiNP_629698.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAA22406; CAA22406; CAA22406.
    GeneIDi1101004.
    KEGGisco:SCO5563.
    PATRICi23741002. VBIStrCoe124346_5652.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939124 Genomic DNA. Translation: CAA22406.1 .
    PIRi T35647.
    RefSeqi NP_629698.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q9ZBR6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO5563.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA22406 ; CAA22406 ; CAA22406 .
    GeneIDi 1101004.
    KEGGi sco:SCO5563.
    PATRICi 23741002. VBIStrCoe124346_5652.

    Phylogenomic databases

    eggNOGi COG0351.
    HOGENOMi HOG000225275.
    KOi K00941.
    OMAi TNHWAYS.
    OrthoDBi EOG6XWV53.
    PhylomeDBi Q9ZBR6.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00137 .
    UPA00060 ; UER00138 .

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    InterProi IPR004399. HMP/HMP-P_kinase.
    IPR013749. PM/HMP-P_kinase-1.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF08543. Phos_pyr_kin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00097. HMP-P_kinase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiTHID_STRCO
    AccessioniPrimary (citable) accession number: Q9ZBR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3