Q9ZBM2 (PSS_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CDP-diacylglycerol--serine O-phosphatidyltransferase
EC=2.7.8.8

Alternative name(s):
Phosphatidylserine synthase

Gene names

Name:	pssA
Ordered Locus Names:	ML0310
ORF Names:	MLCB1450.12

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	CDP-diacylglycerol + L-serine = CMP + (3-sn-phosphatidyl)-L-serine.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	CDP-diacylglycerol metabolic process Inferred from electronic annotation. Source: InterPro phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	CDP-diacylglycerol-serine O-phosphatidyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 300	300	CDP-diacylglycerol--serine O-phosphatidyltransferase		PRO_0000056797
Regions
	Transmembrane	10 – 30	21	Helical; Potential
	Transmembrane	74 – 94	21	Helical; Potential
	Transmembrane	95 – 115	21	Helical; Potential
	Transmembrane	135 – 155	21	Helical; Potential
	Transmembrane	162 – 182	21	Helical; Potential
	Transmembrane	207 – 227	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZBM2 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: B6F61AB52DEF9D25	FASTA	300	32,855
	10 20 30 40 50 60 MTSRPRSRRA VNLQILPSSM TVLSICAGLT SIRFALEHQP KAAIALIAAA AILDGLDGRV 70 80 90 100 110 120 ARILGAESRM GEEIDSLADA VNFGVAPAVV LYATMLSTTP VGWVAVLLYP VCVVLRLARF 130 140 150 160 170 180 NALLDDGTQP AYTREFFVGM PAPAGAVSVI GLLALKLQFG AGWWTSTWFL CIWVTGTSML 190 200 210 220 230 240 LISRIPMKKM HTVSVPPHYA AVFVAMLAIF AAAVVLAPYL LIWVIILTYL CHIPFAIHNQ 250 260 270 280 290 300 RWLAAHPEAW DDKFKQQHDA RRAARRACPN RHAVPRLGLL KPGSRSMVRS GLRKPGRRFI

References

[1]

"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL035159 Genomic DNA. Translation: CAA22696.1. AL583918 Genomic DNA. Translation: CAC29818.1.
PIR	T44730.
RefSeq	NP_301340.1. NC_002677.1.
3D structure databases
ProteinModelPortal	Q9ZBM2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000029341; EBMYCP00000028947; EBMYCG00000029336.
GeneID	909217.
GenomeReviews	Gene locus ML0310 in contig AL450380_GR.
KEGG	mle:ML0310.
NMPDR	fig|272631.1.peg.212.
PATRIC	18051094. VBIMycLep78757_0496.
Organism-specific databases
Leproma	ML0310.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000015994.
HOGENOM	HBG735258.
OMA	AFVYCAC.
ProtClustDB	CLSK790520.
Enzyme and pathway databases
BioCyc	MLEP272631:ML0310-MONOMER.
Family and domain databases
InterPro	IPR004533. CDP-diaglyc--ser_O-PTrfase. IPR000462. CDP-OH_P_trans. [Graphical view]
KO	K00998.
Pfam	PF01066. CDP-OH_P_transf. 1 hit. [Graphical view]
TIGRFAMs	TIGR00473. PssA. 1 hit.
PROSITE	PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PSS_MYCLE

Accession

Primary (citable) accession number: Q9ZBM2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program