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Q9ZBL1

- THID_MYCLE

UniProt

Q9ZBL1 - THID_MYCLE

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Protein

Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene

thiD

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.By similarity

Catalytic activityi

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.
ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541SubstrateBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hydroxymethylpyrimidine kinase activity Source: UniProtKB-EC
  3. phosphomethylpyrimidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00060; UER00137.
UPA00060; UER00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (EC:2.7.1.49, EC:2.7.4.7)
Alternative name(s):
Hydroxymethylpyrimidine kinase
Short name:
HMP kinase
Hydroxymethylpyrimidine phosphate kinase
Short name:
HMP-P kinase
Short name:
HMP-phosphate kinase
Short name:
HMPP kinase
Gene namesi
Name:thiD
Ordered Locus Names:ML0295
ORF Names:MLCB1450.27c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0295.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Hydroxymethylpyrimidine/phosphomethylpyrimidine kinasePRO_0000192022Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0295.

Structurei

3D structure databases

ProteinModelPortaliQ9ZBL1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ThiD family.Curated

Phylogenomic databases

eggNOGiCOG0351.
HOGENOMiHOG000225275.
KOiK00941.
OMAiTNHWAYS.
OrthoDBiEOG6XWV53.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00097. HMP-P_kinase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZBL1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNYLPAPPPG TTPLRVLSIA GSDSGGGAGI QADMRTMTVL GVHACTAVTA
60 70 80 90 100
VTIQNTLGVE GFHEIPAEIV ASQIKAVVTD IGIQSAKTGM LASSSIIAAV
110 120 130 140 150
AETWLRLELT TPLVVDPVCA SMHGDPLLTG EAMDSLRDRL FPLATVVTPN
160 170 180 190 200
LDEVRLLVGI DVVDTESQRA AAMALHALGP QWALVKGGHL RSSDRSCDLL
210 220 230 240 250
YGGSSAGVAF HEFDAPRVQT GNDHGGGDTL AAAVSCALAH GYTVPDAVGF
260 270
GKRWVTECLR DAYPLGRGHG PVSPLFQRT
Length:279
Mass (Da):28,983
Last modified:May 1, 1999 - v1
Checksum:iA9CD5CAFBAD89420
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035159 Genomic DNA. Translation: CAA22711.1.
AL583918 Genomic DNA. Translation: CAC29803.1.
PIRiT44742.
RefSeqiNP_301332.1. NC_002677.1.
WP_010907656.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29803; CAC29803; CAC29803.
GeneIDi908848.
KEGGimle:ML0295.
PATRICi18051028. VBIMycLep78757_0463.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035159 Genomic DNA. Translation: CAA22711.1 .
AL583918 Genomic DNA. Translation: CAC29803.1 .
PIRi T44742.
RefSeqi NP_301332.1. NC_002677.1.
WP_010907656.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q9ZBL1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML0295.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC29803 ; CAC29803 ; CAC29803 .
GeneIDi 908848.
KEGGi mle:ML0295.
PATRICi 18051028. VBIMycLep78757_0463.

Organism-specific databases

Lepromai ML0295.

Phylogenomic databases

eggNOGi COG0351.
HOGENOMi HOG000225275.
KOi K00941.
OMAi TNHWAYS.
OrthoDBi EOG6XWV53.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00137 .
UPA00060 ; UER00138 .

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
InterProi IPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF08543. Phos_pyr_kin. 1 hit.
[Graphical view ]
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00097. HMP-P_kinase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiTHID_MYCLE
AccessioniPrimary (citable) accession number: Q9ZBL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 1, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3