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Q9ZBL1 (THID_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

EC=2.7.1.49
EC=2.7.4.7
Alternative name(s):
Hydroxymethylpyrimidine kinase
Short name=HMP kinase
Hydroxymethylpyrimidine phosphate kinase
Short name=HMP-P kinase
Short name=HMP-phosphate kinase
Short name=HMPP kinase
Gene names
Name:thiD
Ordered Locus Names:ML0295
ORF Names:MLCB1450.27c
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P By similarity.

Catalytic activity

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.

ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 2/3.

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.

Sequence similarities

Belongs to the ThiD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 279279Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
PRO_0000192022

Sites

Binding site541Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZBL1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: A9CD5CAFBAD89420

FASTA27928,983
        10         20         30         40         50         60 
MNYLPAPPPG TTPLRVLSIA GSDSGGGAGI QADMRTMTVL GVHACTAVTA VTIQNTLGVE 

        70         80         90        100        110        120 
GFHEIPAEIV ASQIKAVVTD IGIQSAKTGM LASSSIIAAV AETWLRLELT TPLVVDPVCA 

       130        140        150        160        170        180 
SMHGDPLLTG EAMDSLRDRL FPLATVVTPN LDEVRLLVGI DVVDTESQRA AAMALHALGP 

       190        200        210        220        230        240 
QWALVKGGHL RSSDRSCDLL YGGSSAGVAF HEFDAPRVQT GNDHGGGDTL AAAVSCALAH 

       250        260        270 
GYTVPDAVGF GKRWVTECLR DAYPLGRGHG PVSPLFQRT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL035159 Genomic DNA. Translation: CAA22711.1.
AL583918 Genomic DNA. Translation: CAC29803.1.
PIRT44742.
RefSeqNP_301332.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9ZBL1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML0295.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC29803; CAC29803; CAC29803.
GeneID908848.
KEGGmle:ML0295.
PATRIC18051028. VBIMycLep78757_0463.

Organism-specific databases

LepromaML0295.
CMRSearch...

Phylogenomic databases

eggNOGCOG0351.
HOGENOMHOG000225275.
KOK00941.
OMATNHWAYS.
OrthoDBEOG6XWV53.

Enzyme and pathway databases

UniPathwayUPA00060; UER00137.
UPA00060; UER00138.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
InterProIPR013749. HMP-P_kinase-1.
IPR004399. HMP-P_kinase-2.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00097. HMP-P_kinase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHID_MYCLE
AccessionPrimary (citable) accession number: Q9ZBL1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways