Q9ZBK6 (PSD_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

1. Phosphatidylserine decarboxylase alpha chain
2. Phosphatidylserine decarboxylase beta chain

Gene names

Name:	psd
Ordered Locus Names:	SCO6468
ORF Names:	SC9C7.04c

Organism

Streptomyces coelicolor

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664
Cofactor	Pyruvoyl group By similarity. HAMAP MF_00664
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phosphatidylethanolamine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	cofactor binding Inferred from electronic annotation. Source: InterPro phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 187	187	Phosphatidylserine decarboxylase beta chain By similarity		PRO_0000029811
	Chain	188 – 218	31	Phosphatidylserine decarboxylase alpha chain By similarity		PRO_0000029812
Sites
	Site	187 – 188	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	188	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZBK6 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 4669CC205AA51D88	FASTA	218	23,568
	10 20 30 40 50 60 MPHSQTSAPR DSLAGVRLAR GASPWLLPTV ATAAVSLLRA RRSGTAKAVA VPATALAAGM 70 80 90 100 110 120 LWFFRDPERE ITQGRVVSPA DGVVQSIMPW KDGRTRVAIF MSPLNVHVNR APLAGTVTSV 130 140 150 160 170 180 EHVPGGFVPA FNKESENNER VVWHFDTELG DIEMIQIAGA VARRIVPYVP QGTKVEQGER 190 200 210 VGLIRFGSRV DLYLPEGVEV DVEVGQKTVA GVTRIDRD

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939127 Genomic DNA. Translation: CAA22716.1.
PIR	T35955.
RefSeq	NP_630551.1. NC_003888.3.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1101907.
GenomeReviews	Gene locus SCO6468 in contig AL645882_GR.
KEGG	sco:SCO6468.
NMPDR	fig|100226.1.peg.6406.
PATRIC	23742843. VBIStrCoe124346_6568.
Phylogenomic databases
HOGENOM	HBG541103.
OMA	NERVVWH.
PhylomeDB	Q9ZBK6.
ProtClustDB	PRK05305.
Family and domain databases
HAMAP	MF_00664. PS_decarb_type3. [Tree]
InterPro	IPR003817. PS_Dcarbxylase. IPR004428. PtdSer_deCO2ase-related. [Graphical view]
KO	K01613.
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00164. PS_decarb_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PSD_STRCO

Accession

Primary (citable) accession number: Q9ZBK6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 3, 2003
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program