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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Protein family/group databases

CAZyiGT28. Glycosyltransferase Family 28.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:SCO2084
ORF Names:SC4A10.17c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferasePRO_0000109220Add
BLAST

Proteomic databases

PRIDEiQ9ZBA5.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO2084.

Structurei

3D structure databases

ProteinModelPortaliQ9ZBA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVQ. Bacteria.
COG0707. LUCA.
HOGENOMiHOG000218323.
InParanoidiQ9ZBA5.
KOiK02563.
OMAiEQNALPG.
OrthoDBiEOG61VZFD.
PhylomeDBiQ9ZBA5.

Family and domain databases

HAMAPiMF_00033. MurG.
InterProiIPR006009. GlcNAc_MurG.
IPR007235. Glyco_trans_28_C.
IPR004276. GlycoTrans_28_N.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZBA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVVLAGGGT AGHIEPALAL ADALRRQDPT VGITALGTER GLETRLVPER
60 70 80 90 100
GYELALIPAV PLPRKPTPEL ITVPGRLRGT IKATEQILER TKADAVAGFG
110 120 130 140 150
GYVALPAYLA AKRLGVPIVV HEANARPGLA NKIGSRYAAQ VAVSTPDSKL
160 170 180 190 200
RNSRYIGIPL RRSIATLDRA AARPEARAMF GLDPNLPTLL VTGGSQGARR
210 220 230 240 250
LNEVIQQVAP WLQQAGIQIL HAVGPKNELP QVHQMPGMPP YIPVSYLDRM
260 270 280 290 300
DLAYAAADMM LCRAGAMTVA ELSAVGLPAA YVPLPIGNGE QRLNAQPVVK
310 320 330 340 350
AGGGLLVDDA ELTPEWLQQN VLPVLADPHR LYEMSRAAAE FGRRDADDLL
360
VGMVYEAIAA RARR
Length:364
Mass (Da):38,842
Last modified:May 1, 1999 - v1
Checksum:iD600C5F94E9202E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10879 Genomic DNA. Translation: AAD10537.1.
AL939111 Genomic DNA. Translation: CAB51993.1.
PIRiT34954.
RefSeqiNP_626343.1. NC_003888.3.
WP_003976731.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB51993; CAB51993; CAB51993.
GeneIDi1097518.
KEGGisco:SCO2084.
PATRICi23733816. VBIStrCoe124346_2117.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10879 Genomic DNA. Translation: AAD10537.1.
AL939111 Genomic DNA. Translation: CAB51993.1.
PIRiT34954.
RefSeqiNP_626343.1. NC_003888.3.
WP_003976731.1. NC_003888.3.

3D structure databases

ProteinModelPortaliQ9ZBA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO2084.

Protein family/group databases

CAZyiGT28. Glycosyltransferase Family 28.

Proteomic databases

PRIDEiQ9ZBA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB51993; CAB51993; CAB51993.
GeneIDi1097518.
KEGGisco:SCO2084.
PATRICi23733816. VBIStrCoe124346_2117.

Phylogenomic databases

eggNOGiENOG4105DVQ. Bacteria.
COG0707. LUCA.
HOGENOMiHOG000218323.
InParanoidiQ9ZBA5.
KOiK02563.
OMAiEQNALPG.
OrthoDBiEOG61VZFD.
PhylomeDBiQ9ZBA5.

Enzyme and pathway databases

UniPathwayiUPA00219.

Family and domain databases

HAMAPiMF_00033. MurG.
InterProiIPR006009. GlcNAc_MurG.
IPR007235. Glyco_trans_28_C.
IPR004276. GlycoTrans_28_N.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Kuennen R.A., Stadelmaier B.T., McCormick J.R.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A3(2) / NRRL B-16638.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiMURG_STRCO
AccessioniPrimary (citable) accession number: Q9ZBA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 11, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.