Q9ZB10 (GAL1_STRTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactokinase
EC=2.7.1.6

Alternative name(s):
Galactose kinase

Gene names

Name:

galK

Organism

Streptococcus thermophilus

Taxonomic identifier

1308 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-galactose = ADP + alpha-D-galactose 1-phosphate. HAMAP MF_00246
Pathway	Carbohydrate metabolism; galactose metabolism. HAMAP MF_00246
Subcellular location	Cytoplasm Potential HAMAP MF_00246.
Sequence similarities	Belongs to the GHMP kinase family. GalK subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW galactokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Galactokinase HAMAP MF_00246		PRO_0000184630
Regions
	Nucleotide binding	122 – 132	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZB10 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 97785356F20944AF	FASTA	388	43,450
	10 20 30 40 50 60 MNTSQLREKF KEVFGVEADH TFFSPGRINL IGEHTDYNGG NVLPVAITLG TYGAARKRDD 70 80 90 100 110 120 KVLRFFSANF EEKGIIEVPL ENLRFEKEHN WTNYPKGVLH FLQEAGHTID SGMDIYIYGN 130 140 150 160 170 180 IPNGSGLSSS SSLELLIGVI VEKLYDIKLE RLDLVKIGKQ TENDFIGVNS GIMDQFAIGM 190 200 210 220 230 240 GADQCAIYLD TNTLKYDLVP LDLKDNVVVI MNTNKRRELA DSKYNERRAE CETAVSELQE 250 260 270 280 290 300 KLDIQTLGEL DFLTFDAYSY LIKDENRIKR ARHVVLENQR TLQARKALET GDLEGFGRLM 310 320 330 340 350 360 NASHVSLEYD YEVTGLELDT LAHTAWEQEG VLGARMTGAG FGGCAIALVN KDKVEDFKKA 370 380 VGQRYEEVVG YAPSFYIAEV TGGSRVLD

References

[1]	"Activation of silent gal genes in the lac-gal regulon of Streptococcus thermophilus." Vaughan E.E., van den Bogaard P.T.C., Catzeddu P., Kuipers O.P., de Vos W.M. J. Bacteriol. 183:1184-1194(2001) [PubMed: 11157930] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: CNRZ 302.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U61402 Genomic DNA. Translation: AAD00093.1.
3D structure databases
ProteinModelPortal	Q9ZB10.
SMR	Q9ZB10. Positions 4-387.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_00246. Galactokinase. [Tree]
InterPro	IPR000705. Galactokinase. IPR022963. Galactokinase_bac. IPR019741. Galactokinase_CS. IPR019539. GalKase_gal-bd. IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP-bd_CS. IPR006206. Mevalonate/galactokinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
Pfam	PF10509. GalKase_gal_bdg. 1 hit. PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000530. Galactokinase. 1 hit.
PRINTS	PR00473. GALCTOKINASE. PR00959. MEVGALKINASE.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00131. Gal_kin. 1 hit.
PROSITE	PS00106. GALACTOKINASE. 1 hit. PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GAL1_STRTR

Accession

Primary (citable) accession number: Q9ZB10

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1999
Last modified:	May 31, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program