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Protein

Galactokinase

Gene

galK

Organism
Streptococcus thermophilus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).UniRule annotation

Catalytic activityi

ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate.UniRule annotation

Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei27Transition state stabilizerUniRule annotation1
Binding sitei67ATPUniRule annotation1
Metal bindingi130MagnesiumUniRule annotation1
Metal bindingi162MagnesiumUniRule annotation1
Active sitei174Proton acceptorUniRule annotation1
Binding sitei224SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi124 – 130ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Galactose metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00214.

Names & Taxonomyi

Protein namesi
Recommended name:
GalactokinaseUniRule annotation (EC:2.7.1.6UniRule annotation)
Alternative name(s):
Galactose kinaseUniRule annotation
Gene namesi
Name:galKUniRule annotation
OrganismiStreptococcus thermophilus
Taxonomic identifieri1308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001846301 – 388GalactokinaseAdd BLAST388

Interactioni

Protein-protein interaction databases

STRINGi264199.stu1402.

Structurei

3D structure databases

ProteinModelPortaliQ9ZB10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni33 – 36Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the GHMP kinase family. GalK subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CRD. Bacteria.
COG0153. LUCA.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00246. Galactokinase. 1 hit.
InterProiIPR000705. Galactokinase.
IPR022963. Galactokinase_bac.
IPR019741. Galactokinase_CS.
IPR019539. GalKase_gal-bd.
IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10457. PTHR10457. 1 hit.
PTHR10457:SF6. PTHR10457:SF6. 1 hit.
PfamiPF10509. GalKase_gal_bdg. 1 hit.
PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000530. Galactokinase. 1 hit.
PRINTSiPR00473. GALCTOKINASE.
PR00959. MEVGALKINASE.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00131. gal_kin. 1 hit.
PROSITEiPS00106. GALACTOKINASE. 1 hit.
PS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZB10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTSQLREKF KEVFGVEADH TFFSPGRINL IGEHTDYNGG NVLPVAITLG
60 70 80 90 100
TYGAARKRDD KVLRFFSANF EEKGIIEVPL ENLRFEKEHN WTNYPKGVLH
110 120 130 140 150
FLQEAGHTID SGMDIYIYGN IPNGSGLSSS SSLELLIGVI VEKLYDIKLE
160 170 180 190 200
RLDLVKIGKQ TENDFIGVNS GIMDQFAIGM GADQCAIYLD TNTLKYDLVP
210 220 230 240 250
LDLKDNVVVI MNTNKRRELA DSKYNERRAE CETAVSELQE KLDIQTLGEL
260 270 280 290 300
DFLTFDAYSY LIKDENRIKR ARHVVLENQR TLQARKALET GDLEGFGRLM
310 320 330 340 350
NASHVSLEYD YEVTGLELDT LAHTAWEQEG VLGARMTGAG FGGCAIALVN
360 370 380
KDKVEDFKKA VGQRYEEVVG YAPSFYIAEV TGGSRVLD
Length:388
Mass (Da):43,450
Last modified:May 1, 1999 - v1
Checksum:i97785356F20944AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61402 Genomic DNA. Translation: AAD00093.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61402 Genomic DNA. Translation: AAD00093.1.

3D structure databases

ProteinModelPortaliQ9ZB10.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264199.stu1402.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CRD. Bacteria.
COG0153. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00214.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00246. Galactokinase. 1 hit.
InterProiIPR000705. Galactokinase.
IPR022963. Galactokinase_bac.
IPR019741. Galactokinase_CS.
IPR019539. GalKase_gal-bd.
IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10457. PTHR10457. 1 hit.
PTHR10457:SF6. PTHR10457:SF6. 1 hit.
PfamiPF10509. GalKase_gal_bdg. 1 hit.
PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000530. Galactokinase. 1 hit.
PRINTSiPR00473. GALCTOKINASE.
PR00959. MEVGALKINASE.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00131. gal_kin. 1 hit.
PROSITEiPS00106. GALACTOKINASE. 1 hit.
PS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAL1_STRTR
AccessioniPrimary (citable) accession number: Q9ZB10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: October 5, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.