Reviewed, UniProtKB/Swiss-Prot Q9ZB09 (GALT_STRTR)

Names and origin

Protein names

Recommended name:
    Galactose-1-phosphate uridylyltransferase
      Short name=Gal-1-P uridylyltransferase
    EC=2.7.7.12
Alternative name(s):
    UDP-glucose--hexose-1-phosphate uridylyltransferase

Gene names

Name:

galT

Organism

Streptococcus thermophilus

Taxonomic identifier

1308 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose. HAMAP MF_00571
Pathway	Carbohydrate metabolism; galactose metabolism. HAMAP MF_00571
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Cellular component	Cytoplasm
Molecular function	Nucleotidyltransferase Transferase
Gene Ontology (GO)
Biological process	galactose metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UDP-glucose:hexose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	Galactose-1-phosphate uridylyltransferase HAMAP MF_00571		PRO_0000169919
Natural variations
	Natural variant	42	1	I → V in strain: SMQ-301.
	Natural variant	70	1	K → N in strain: SMQ-301.
	Natural variant	107	1	I → T in strain: SMQ-301.
	Natural variant	243	1	V → A in strain: SMQ-301.
	Natural variant	480	1	A → D in strain: SMQ-301.

Sequences

	Sequence		Length	Mass (Da)
	Q9ZB09-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 203F5449A40A5FEF	FASTA	493	55,413
	10 20 30 40 50 60 MAENLVNTFV TQVIENSDYE ELDRIYLTNK VFTLVGEGVA DIETDSSELI DLKDQLLQAG 70 80 90 100 110 120 VKAGSVGELK EEQDIIGAQL MDLITPRPSV VNRNFWDTYK SNPEQAIADF YAQSKRNDYV 130 140 150 160 170 180 KVKAIAQNIA YKAPTKYGDL EITINLSKPE KDPKAIAAAK NAVASDYPKC QLCMENEGYL 190 200 210 220 230 240 GRINHPARSN HRVVRFQMED KEWGFQYSPY AYFNEHSIFF YGKHEPMHIS PLTFGRLLTI 250 260 270 280 290 300 VEVFPGYFAG SNADLPIVGG SILTHEHYQG GRHTFPMEVA GIKEKVSFDG YSDVEAGIVN 310 320 330 340 350 360 WPMSVLRLRS EDKGRLIALA TKILNCWRGY SDEKAGVLAE SDGQPHHTIT PIARRKDGKF 370 380 390 400 410 420 ELDLVLRDNQ TSEEYPDGIY HPHKDVQHIK KENIGLIEVM GLAILPPRLK TELKDVEDYL 430 440 450 460 470 480 LGQGNQVAPI HQEWADELKA QNPNITAEEV TEVVRQSVAD IFARVLEDAG VYKTNSEGLA 490 QFKAFVDFVN LAD

References

[1]

"Activation of silent gal genes in the lac-gal regulon of Streptococcus thermophilus." Vaughan E.E., van den Bogaard P.T.C., Catzeddu P., Kuipers O.P., de Vos W.M. J. Bacteriol. 183:1184-1194(2001) [PubMed: 11157930] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: CNRZ 302.

[2]

"Galactose and lactose genes from the galactose-positive bacterium Streptococcus salivarius and the phylogenetically related galactose-negative bacterium Streptococcus thermophilus: organization, sequence, transcription, and activity of the gal gene products." Vaillancourt K., Moineau S., Frenette M., Lessard C., Vadeboncoeur C. J. Bacteriol. 184:785-793(2002) [PubMed: 11790749] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SMQ-301.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U61402 Genomic DNA. Translation: AAD00094.1. AF389475 Genomic DNA. Translation: AAL67297.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.7.12. 1164.
Family and domain databases
HAMAP	MF_00571. [Tree]
InterPro	IPR000766. GalP_uridyl_Trfase_II. IPR005850. GalP_Utransf_C. IPR005849. GalP_Utransf_N. [Graphical view]
Pfam	PF02744. GalP_UDP_tr_C. 1 hit. PF01087. GalP_UDP_transf. 1 hit. [Graphical view]
PIRSF	PIRSF006005. GalT_BS. 1 hit.
TIGRFAMs	TIGR01239. galT_2. 1 hit.
PROSITE	PS01163. GAL_P_UDP_TRANSF_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GALT_STRTR

Accession

Primary (citable) accession number: Q9ZB09
Secondary accession number(s): Q8VS86

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1999
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)