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Q9ZAI3

- Q9ZAI3_9ACTO

UniProt

Q9ZAI3 - Q9ZAI3_9ACTO

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Protein

Xylose isomerase

Gene
xylA
Organism
Streptomyces sp. SK
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei54 – 541 By similarityUniRule annotation
Active sitei57 – 571 By similarityUniRule annotation
Metal bindingi181 – 1811MagnesiumImported
Metal bindingi181 – 1811Magnesium 1 By similarityUniRule annotation
Metal bindingi217 – 2171CobaltImported
Metal bindingi217 – 2171MagnesiumImported
Metal bindingi217 – 2171Magnesium 1 By similarityUniRule annotation
Metal bindingi217 – 2171Magnesium 2 By similarityUniRule annotation
Metal bindingi220 – 2201Cobalt; via tele nitrogenImported
Metal bindingi220 – 2201Magnesium 2 By similarityUniRule annotation
Metal bindingi245 – 2451MagnesiumImported
Metal bindingi245 – 2451Magnesium 1 By similarityUniRule annotation
Metal bindingi255 – 2551CobaltImported
Metal bindingi255 – 2551Magnesium 2 By similarityUniRule annotation
Metal bindingi257 – 2571CobaltImported
Metal bindingi257 – 2571Magnesium 2 By similarityUniRule annotation
Metal bindingi287 – 2871MagnesiumImported
Metal bindingi287 – 2871Magnesium 1 By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotationSAAS annotations, Xylose metabolismUniRule annotationSAAS annotations

Keywords - Ligandi

CobaltImported, MagnesiumUniRule annotationImported, Metal-bindingUniRule annotationSAAS annotationsImported

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotationImported
OrganismiStreptomyces sp. SKImported
Taxonomic identifieri253732 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HHLX-ray1.73A/B1-388[»]
4HHMX-ray2.15A/B/C/D/E/F/G/H1-388[»]
ProteinModelPortaliQ9ZAI3.
SMRiQ9ZAI3. Positions 2-387.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZAI3-1 [UniParc]FASTAAdd to Basket

« Hide

MNYQPTPEDR FTFGLWTVGW QGRDPFGDAT RPALDPVEAV QRLAELGAYG    50
VTFHDDDLIP FGASDTEREA HVKRFRQALD ATGMTVPMAT TNLFTHPVFK 100
DGAFTANDRD VRRYALRKTI RNIDLAVELG AKVYVAWGGR EGAESGAAKD 150
VRAALDRMKE AFDLLGEYVT SQGYDIRFAI EPKPNEPRGD ILLPTIGHAL 200
AFIERLERPE LYGVNPEVGH EQMAGLNFPH GIAQALWAGK LFHIDLNGQS 250
GIKYDQDLRF GAGDLRAAFW LVDLLESAGW EGPRHFDFKP PRTEDIDGVW 300
ASAAGCMRNY LILKERAAAF RADPEVQEAL RAARLDQLAE PTAADGLQAL 350
LADRTAYEDF DVDAAAARGM AFERLDQLAM DHLLGARG 388
Length:388
Mass (Da):42,946
Last modified:March 1, 2004 - v2
Checksum:i034009333C53DE5B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y15518 Genomic DNA. Translation: CAA75672.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y15518 Genomic DNA. Translation: CAA75672.2 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HHL X-ray 1.73 A/B 1-388 [» ]
4HHM X-ray 2.15 A/B/C/D/E/F/G/H 1-388 [» ]
ProteinModelPortali Q9ZAI3.
SMRi Q9ZAI3. Positions 2-387.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.150. 1 hit.
HAMAPi MF_00455. Xylose_isom_A.
InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view ]
Pfami PF01261. AP_endonuc_2. 1 hit.
[Graphical view ]
PRINTSi PR00688. XYLOSISMRASE.
SUPFAMi SSF51658. SSF51658. 1 hit.
TIGRFAMsi TIGR02631. xylA_Arthro. 1 hit.
PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Belghith-Srih K.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SKImported.
  2. "Identification of critical residues for the activity and thermostability of Streptomyces sp. SK glucose isomerase."
    Ben Hlima H., Bejar S., Riguet J., Haser R., Aghajari N.
    Appl. Microbiol. Biotechnol. 97:9715-9726(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.73 ANGSTROMS) IN COMPLEX WITH COBALT AND MAGNESIUM.

Entry informationi

Entry nameiQ9ZAI3_9ACTO
AccessioniPrimary (citable) accession number: Q9ZAI3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: March 1, 2004
Last modified: June 11, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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