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Q9ZAI3

- Q9ZAI3_9ACTO

UniProt

Q9ZAI3 - Q9ZAI3_9ACTO

Protein

Xylose isomerase

Gene

xylA

Organism
Streptomyces sp. SK
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 2 (01 Mar 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

    Cofactori

    Binds 2 magnesium ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei54 – 541UniRule annotation
    Active sitei57 – 571UniRule annotation
    Metal bindingi181 – 1811MagnesiumImported
    Metal bindingi181 – 1811Magnesium 1UniRule annotation
    Metal bindingi217 – 2171MagnesiumImported
    Metal bindingi217 – 2171Magnesium 1UniRule annotation
    Metal bindingi217 – 2171Magnesium 2UniRule annotation
    Metal bindingi220 – 2201Magnesium 2UniRule annotation
    Metal bindingi245 – 2451MagnesiumImported
    Metal bindingi245 – 2451Magnesium 1UniRule annotation
    Metal bindingi255 – 2551Magnesium 2UniRule annotation
    Metal bindingi257 – 2571Magnesium 2UniRule annotation
    Metal bindingi287 – 2871MagnesiumImported
    Metal bindingi287 – 2871Magnesium 1UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. xylose isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-xylose metabolic process Source: UniProtKB-HAMAP
    2. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Carbohydrate metabolism, Pentose shuntUniRule annotationSAAS annotation, Xylose metabolismUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationImported, Metal-bindingUniRule annotationSAAS annotationImported

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
    Gene namesi
    Name:xylAUniRule annotationImported
    OrganismiStreptomyces sp. SKImported
    Taxonomic identifieri253732 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HHLX-ray1.73A/B1-388[»]
    4HHMX-ray2.15A/B/C/D/E/F/G/H1-388[»]
    ProteinModelPortaliQ9ZAI3.
    SMRiQ9ZAI3. Positions 2-387.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the xylose isomerase family.UniRule annotation

    Family and domain databases

    Gene3Di3.20.20.150. 1 hit.
    HAMAPiMF_00455. Xylose_isom_A.
    InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013453. XylA_actinobac.
    IPR001998. Xylose_isomerase.
    [Graphical view]
    PfamiPF01261. AP_endonuc_2. 1 hit.
    [Graphical view]
    PRINTSiPR00688. XYLOSISMRASE.
    SUPFAMiSSF51658. SSF51658. 1 hit.
    TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
    PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZAI3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNYQPTPEDR FTFGLWTVGW QGRDPFGDAT RPALDPVEAV QRLAELGAYG    50
    VTFHDDDLIP FGASDTEREA HVKRFRQALD ATGMTVPMAT TNLFTHPVFK 100
    DGAFTANDRD VRRYALRKTI RNIDLAVELG AKVYVAWGGR EGAESGAAKD 150
    VRAALDRMKE AFDLLGEYVT SQGYDIRFAI EPKPNEPRGD ILLPTIGHAL 200
    AFIERLERPE LYGVNPEVGH EQMAGLNFPH GIAQALWAGK LFHIDLNGQS 250
    GIKYDQDLRF GAGDLRAAFW LVDLLESAGW EGPRHFDFKP PRTEDIDGVW 300
    ASAAGCMRNY LILKERAAAF RADPEVQEAL RAARLDQLAE PTAADGLQAL 350
    LADRTAYEDF DVDAAAARGM AFERLDQLAM DHLLGARG 388
    Length:388
    Mass (Da):42,946
    Last modified:March 1, 2004 - v2
    Checksum:i034009333C53DE5B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y15518 Genomic DNA. Translation: CAA75672.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y15518 Genomic DNA. Translation: CAA75672.2 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HHL X-ray 1.73 A/B 1-388 [» ]
    4HHM X-ray 2.15 A/B/C/D/E/F/G/H 1-388 [» ]
    ProteinModelPortali Q9ZAI3.
    SMRi Q9ZAI3. Positions 2-387.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.20.20.150. 1 hit.
    HAMAPi MF_00455. Xylose_isom_A.
    InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013453. XylA_actinobac.
    IPR001998. Xylose_isomerase.
    [Graphical view ]
    Pfami PF01261. AP_endonuc_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00688. XYLOSISMRASE.
    SUPFAMi SSF51658. SSF51658. 1 hit.
    TIGRFAMsi TIGR02631. xylA_Arthro. 1 hit.
    PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Belghith-Srih K.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: SKImported.
    2. "Identification of critical residues for the activity and thermostability of Streptomyces sp. SK glucose isomerase."
      Ben Hlima H., Bejar S., Riguet J., Haser R., Aghajari N.
      Appl. Microbiol. Biotechnol. 97:9715-9726(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.73 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.

    Entry informationi

    Entry nameiQ9ZAI3_9ACTO
    AccessioniPrimary (citable) accession number: Q9ZAI3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 1999
    Last sequence update: March 1, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3