Q9ZAH6 (ACPS_STAA8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Holo-[acyl-carrier-protein] synthase
Short name=Holo-ACP synthase
EC=2.7.8.7

Alternative name(s):
4'-phosphopantetheinyl transferase AcpS

Gene names

Name:	acpS
Synonyms:	dpj
Ordered Locus Names:	SAOUHSC_02306

Organism

Staphylococcus aureus (strain NCTC 8325)

Taxonomic identifier

93061 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	119 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein By similarity. HAMAP MF_00101
Catalytic activity	CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein]. HAMAP MF_00101
Cofactor	Magnesium By similarity. HAMAP MF_00101
Subcellular location	Cytoplasm By similarity HAMAP MF_00101.
Sequence similarities	Belongs to the P-Pant transferase superfamily. AcpS family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW macromolecule biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	holo-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 119	119	Holo-[acyl-carrier-protein] synthase HAMAP MF_00101		PRO_0000175699
Sites
	Metal binding	8	1	Magnesium By similarity
	Metal binding	59	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZAH6 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 0B828A811774B138	FASTA	119	13,606
	10 20 30 40 50 60 MIHGIGVDLI EIDRIQALYS KQPKLVERIL TKNEQHKFNN FTHEQRKIEF LAGRFATKEA 70 80 90 100 110 FSKALGTGLG KHVAFNDIDC YNDELGKPKI DYEGFIVHVS ISHTEHYAMS QVVLEKSAF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of the putative alanine racemase operon in Staphylococcus aureus: insertional interruption of this operon reduces D-alanine substitution of lipoteichoic acid and autolysis." Kullik I., Jenni R., Berger-Baechi B. Gene 219:9-17(1998) [PubMed: 9756984] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The Staphylococcus aureus NCTC8325 genome." Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 8325.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y16431 Genomic DNA. Translation: CAA76220.1. CP000253 Genomic DNA. Translation: ABD31340.1.
RefSeq	YP_500785.1. NC_007795.1.
3D structure databases
ProteinModelPortal	Q9ZAH6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ZAH6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000029380; EBSTAP00000028331; EBSTAG00000029378.
GeneID	3920931.
GenomeReviews	Gene locus SAOUHSC_02306 in contig CP000253_GR.
KEGG	sao:SAOUHSC_02306.
PATRIC	19581947. VBIStaAur99865_2090.
Phylogenomic databases
eggNOG	COG0736.
GeneTree	EBGT00050000025046.
HOGENOM	HBG734479.
OMA	VHVSITH.
ProtClustDB	PRK00070.
Enzyme and pathway databases
BioCyc	SAUR93061:SAOUHSC_02306-MONOMER.
Family and domain databases
HAMAP	MF_00101. AcpS. [Tree]
InterPro	IPR008278. 4-PPantetheinyl_Trfase. IPR002582. ACPS. IPR004568. PPantethiene-prot_Trfase. [Graphical view]
Gene3D	G3DSA:3.90.470.20. G3DSA:3.90.470.20. 1 hit.
KO	K00997.
Pfam	PF01648. ACPS. 1 hit. [Graphical view]
ProDom	PD004282. PPantethiene-prot_Trfase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF56214. 4-PPT_transf. 1 hit.
TIGRFAMs	TIGR00516. AcpS. 1 hit. TIGR00556. Pantethn_trn. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACPS_STAA8

Accession

Primary (citable) accession number: Q9ZAH6
Secondary accession number(s): Q2FWI5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program