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Protein

ATP-dependent Clp protease proteolytic subunit

Gene

clpP

Organism
Lactococcus lactis subsp. cremoris (strain MG1363)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei99NucleophileUniRule annotation1
Active sitei124UniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • misfolded or incompletely synthesized protein catabolic process Source: CACAO

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processStress response

Enzyme and pathway databases

BRENDAi3.4.21.92. 2903.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunitUniRule annotation (EC:3.4.21.92UniRule annotation)
Alternative name(s):
Endopeptidase ClpUniRule annotation
Gene namesi
Name:clpPUniRule annotation
Ordered Locus Names:llmg_0638
OrganismiLactococcus lactis subsp. cremoris (strain MG1363)
Taxonomic identifieri416870 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000000364 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001795741 – 199ATP-dependent Clp protease proteolytic subunitAdd BLAST199

Expressioni

Inductioni

By heat shock.

Interactioni

Subunit structurei

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

Protein-protein interaction databases

STRINGi416870.llmg_0638.

Structurei

3D structure databases

ProteinModelPortaliQ9ZAB0.
SMRiQ9ZAB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CCQ. Bacteria.
COG0740. LUCA.
HOGENOMiHOG000285833.
KOiK01358.
OMAiLFLQSEN.

Family and domain databases

CDDicd07017. S14_ClpP_2. 1 hit.
HAMAPiMF_00444. ClpP. 1 hit.
InterProiView protein in InterPro
IPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR033135. ClpP_His_AS.
IPR018215. ClpP_Ser_AS.
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiView protein in Pfam
PF00574. CLP_protease. 1 hit.
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiView protein in PROSITE
PS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZAB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYLVPTVIE QSSRGERAYD IYSRLLKDRI IMLTGPVEDG MANSIIAQLL
60 70 80 90 100
FLDAQDNTKD IYLYVNTPGG SVSAGLAIVD TMNFIKSDVQ TIVMGMAASM
110 120 130 140 150
GTIIASSGTK GKRFMLPNAE YLIHQPMGGA GQGTQQTDMA IVAEQLLKTR
160 170 180 190
KRLEQILADN SNRSLEQIHK DAERDHWMDA KETLEYGFID EIMENNSLK
Length:199
Mass (Da):22,052
Last modified:March 1, 2001 - v2
Checksum:iF2CC13835891CCFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028804 Genomic DNA. Translation: AAD01866.2.
AM406671 Genomic DNA. Translation: CAL97240.1.
RefSeqiWP_011834647.1. NC_009004.1.

Genome annotation databases

EnsemblBacteriaiCAL97240; CAL97240; llmg_0638.
KEGGillm:llmg_0638.

Similar proteinsi

Entry informationi

Entry nameiCLPP_LACLM
AccessioniPrimary (citable) accession number: Q9ZAB0
Secondary accession number(s): A2RIZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: September 27, 2017
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families