ID   LON_CHLPN               Reviewed;         819 AA.
AC   Q9Z9F4; Q9JQ69;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   16-JUN-2009, entry version 68.
DE   RecName: Full=ATP-dependent protease La;
DE            EC=3.4.21.53;
GN   Name=lon; OrderedLocusNames=CPn_0027, CP_0749, CpB0031;
OS   Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae; Chlamydophila.
OX   NCBI_TaxID=83558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CWL029;
RX   MEDLINE=99206606; PubMed=10192388; DOI=10.1038/7716;
RA   Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA   Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT   "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL   Nat. Genet. 21:385-389(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR39;
RX   MEDLINE=20150255; PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F.,
RA   White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J.,
RA   Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C.,
RA   Dodson R.J., Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F.,
RA   McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia
RT   pneumoniae AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J138;
RX   MEDLINE=20330349; PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA   Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA   Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT   "Comparison of whole genome sequences of Chlamydia pneumoniae J138
RT   from Japan and CWL029 from USA.";
RL   Nucleic Acids Res. 28:2311-2314(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TW-183;
RA   Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA   Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT   "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT   other Chlamydia strains based on whole genome sequence analysis.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Degrades short-lived regulatory and abnormal proteins in
CC       presence of ATP. Hydrolyzes two ATPs for each peptide bond cleaved
CC       in the protein substrate (By similarity).
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of proteins in presence of ATP.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the peptidase S16 family.
CC   -!- SIMILARITY: Contains 1 Lon domain.
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DR   EMBL; AE001363; AAD18180.1; -; Genomic_DNA.
DR   EMBL; AE002161; AAF38554.1; -; Genomic_DNA.
DR   EMBL; BA000008; BAA98239.1; -; Genomic_DNA.
DR   EMBL; AE017157; AAP97964.1; -; Genomic_DNA.
DR   PIR; B72128; B72128.
DR   PIR; E86494; E86494.
DR   RefSeq; NP_224235.1; -.
DR   RefSeq; NP_300088.1; -.
DR   RefSeq; NP_445291.1; -.
DR   RefSeq; NP_876307.1; -.
DR   MEROPS; S16.002; -.
DR   GeneID; 1466714; -.
DR   GeneID; 894928; -.
DR   GeneID; 918819; -.
DR   GeneID; 963156; -.
DR   GenomeReviews; AE001363_GR; CPn_0027.
DR   GenomeReviews; AE002161_GR; CP_0749.
DR   GenomeReviews; AE009440_GR; CpB0031.
DR   GenomeReviews; BA000008_GR; lon.
DR   KEGG; cpa:CP0749; -.
DR   KEGG; cpn:CPn0027; -.
DR   KEGG; cpt:CpB0031; -.
DR   TIGR; CP_0749; -.
DR   HOGENOM; Q9Z9F4; -.
DR   OMA; Q9Z9F4; WGNYSDE.
DR   BioCyc; CPNE115711:CP_0749-MON; -.
DR   BioCyc; CPNE115713:CPN0027-MON; -.
DR   BioCyc; CPNE138677:CPJ0027-MON; -.
DR   BioCyc; CPNE182082:CPB0031-MON; -.
DR   BRENDA; 3.4.21.53; 264832.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR003593; ATPase_AAA+_core.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR008269; Pept_S16_C.
DR   InterPro; IPR004815; Pept_S16_lon.
DR   InterPro; IPR003111; Pept_S16_N.
DR   InterPro; IPR008268; Peptidase_S16_AS.
DR   InterPro; IPR001984; Peptidase_S16_C.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF02190; LON; 1.
DR   Pfam; PF05362; Lon_C; 1.
DR   PRINTS; PR00830; ENDOLAPTASE.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00464; LON; 1.
DR   TIGRFAMs; TIGR00763; lon; 1.
DR   PROSITE; PS01046; LON_SER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Hydrolase;
KW   Nucleotide-binding; Protease; Serine protease.
FT   CHAIN         1    819       ATP-dependent protease La.
FT                                /FTId=PRO_0000076131.
FT   DOMAIN       42    238       Lon.
FT   NP_BIND     393    400       ATP (Potential).
FT   ACT_SITE    723    723       By similarity.
FT   ACT_SITE    766    766       By similarity.
SQ   SEQUENCE   819 AA;  92276 MW;  788BCB2A0D294E6A CRC64;
     MDSTTNSDSP ILDPNPEDVE KLLDESEEES EDQSTERLLP SELFILPLNK RPFFPGMAAP
     ILIESGPYYE VLKVLAKSSQ KYIGLVLTKK ENADILKVSF NQLHKTGVAA RILRIMPIEG
     GSAQVLLSIE ERIRIIEPIK DKYLKARVSY HADNKELTEE LKAYSISIVS VIKDLLKLNP
     LFKEELQIFL GHSDFTEPGK LADFSVALTT ATREELQEVL ETTNMHDRID KALILLKKEL
     DLSRLQSSIN QKIEATITKS QKEFFLKEQL KTIKKELGLE KEDRAIDIEK FSERLRKRHV
     PDYAMEVIQD EIEKLQTLET SSAEYTVCRN YLDWLTIIPW GIQSKEYHDL KKAEIVLNKD
     HYGLDEIKQR ILELISVGKL SKGLKGSIIC LVGPPGVGKT SIGRSIAKVL HRKFFRFSVG
     GMRDEAEIKG HRRTYIGAMP GKMVQALKQS QAMNPVIMID EVDKIGASYH GDPASALLEV
     LDPEQNKDFL DHYLDVRVDL SNVLFILTAN VLDTIPDPLL DRMEILRLSG YILEEKLQIA
     KKYLVPKARK EIGLTASEVN FQPEALKYMI NNYAREAGVR TLNGNIKKVL RKVALKIVQN
     QEKPKSKKIT FKISSKNLQT YLGKPIFSSD RFYESTPVGV ATGLAWTSLG GATLYIESVQ
     VSSLKTDMHL TGQAGEVMKE SSQIAWTYLH SALHRYAPGY TFFPKSQVHI HIPEGATPKD
     GPSAGITMVT SLLSLLLETP VVNNLGMTGE ITLTGRVLGV GGIREKLIAA RRSRLNILIF
     PEDNRRDYEE LPAYLKTGLK IHFVSHYDDV LKVAFPKLK
//